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LAMB2 Proteine

(Laminin, beta 2 (Laminin S) (LAMB2))
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011].

10 Treffer

LAMB2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, ELISA
Produktnummer ABIN7577882
 
LAMB2 Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, Imm, PC
Produktnummer ABIN7404077
 
LAMB2 Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS, WB, Imm, PC
Produktnummer ABIN7401872
 
LAMB2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS, WB, Imm, PC
Produktnummer ABIN7395851
 
LAMB2 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, Imm, PC
Produktnummer ABIN7414516
 
LAMB2 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, Imm, PC
Produktnummer ABIN7414513
 
LAMB2 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, Imm, PC
Produktnummer ABIN7414519
 
LAMB2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Produktnummer ABIN5712898
 
LAMB2 Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, ELISA, IP
Produktnummer ABIN3010414
 
LAMB2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2724491
 
  • Typ Protein
    • Protein
  • Anwendung
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Immunogen (Imm)
    • Positive Control (PC)
    • ELISA
    • Antibody Production (AbP)
    • Immunoprecipitation (IP)
    • Standard (STD)
  • Reaktivität
    • Human
    • Mouse
    • Rat
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • Escherichia coli (E. coli)
    • HEK-293 Cells
  • Bindungsspezifität
    • AA 1176-1309
    • AA 1178-1311
    • AA 1498-1716
    • AA 1530-1798
    • AA 38-350
    • AA 75-223
    • AA 939-1129
    • partial
  • Konjugat
    • His tag
    • GST tag
    • His tag,GST tag
    • Myc-DYKDDDDK Tag
    • Unkonjugiert
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Hersteller
    • antibodies-online
    • Abbexa
    • OriGene
    • Signalway

Aliase für LAMB2 Proteine

laminin subunit beta 2 (LAMB2) Proteine
laminin, beta 2 (Lamb2) Proteine
laminin subunit beta 2 (Lamb2) Proteine
laminin subunit beta 2 L homeolog (lamb2.L) Proteine
laminin, beta 2 (laminin S) (LAMB2) Proteine
AW211941 Proteine
Lamb-2 Proteine
lamb1 Proteine
LAMC1 Proteine
laminin Proteine
LAMS Proteine
Lams Proteine
lams Proteine
NPHS5 Proteine
SLAM Proteine
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