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anti-Human FCN1 Antikörper:
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Human Polyclonal FCN1 Primary Antibody für IHC, IHC (p) - ABIN4311880
Okuzaki, Kimura, Yabuta, Ohmine, Nojima: LeukoCatch, a quick and efficient tool for the preparation of leukocyte extracts from blood. in BMC clinical pathology 2011
Show all 2 Pubmed References
Human Polyclonal FCN1 Primary Antibody für IHC, IHC (p) - ABIN4311879
Sterba, Dupejova, Fiser, Vancova, Grubhoffer: Fibrinogen-related proteins in ixodid ticks. in Parasites & vectors 2011
M-ficolin interacts with A. fumigatus through interaction with chitin and beta-1,3 glucan and thereby mediates complement activation and potentiates IL-8 (zeige IL8 Antikörper) secretion of A549 cells.
higher ficolin-1 levels were associated with brain ischemic lesions and vasospasm following subarachnoid hemorrhage.
in northeastern Brazilian children and adolescents, FCN1 rs1071583 SNP was correlated with earlier age of type 1 diabetes mellitus (T1D) diagnosis; the SNP combination rs2989727 and rs1071583 was involved with T1D protection
Ficolin-1 could provide an alternative receptor-mediated mechanism for enhancing Ebola Virus infection, thereby contributing to viral subversion of the host innate immune system.
systemic lupus erythematosus patients with high ficolin-1 plasma levels had an increased risk of end-stage renal disease; there was no significant association between ficolin-1 and ficolin-3 (zeige FCN3 Antikörper) with lupus nephritis
Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 mug/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher
Data indicate differences in the plasma concentrations of collectin liver 1 (zeige COLEC10 Antikörper) and collectin (zeige MBL2 Antikörper) kidney 1 (zeige ZNF354A Antikörper), M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls.
This study aims to investigate whether an association exists between the ficolins that are part of the lectin complement pathway and systemic lupus erythematosus.
the differential binding of ficolin-1 to lymphocyte subsets suggests ficolin-1 as a novel link between innate and adaptive immunity.
In patients with early rheumatoid arthritis, elevated plasma M-ficolin levels correlated with a high disease activity score at baseline and 1 year. A low M-ficolin level was the strongest predictor of remission and low disease activity.
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.
, collagen/fibrinogen domain-containing protein 1
, ficolin (collagen/fibrinogen domain-containing) 1
, ficolin B
, collagen/fibrinogen domain-containing protein 2
, ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
, ficolin 2
, ficolin (collagen/fibrinogen domain containing) 1