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Human CD55 Protein expressed in Human Cells - ABIN2002065
Bergelson, Chan, Solomon, St John, Lin, Finberg: Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses. in Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 5 Pubmed References
the first comprehensive analysis of variation in the CD55 gene in the context of Severe malaria.
CD55 rs2564978 polymorphism may contribute to an increased risk of non-small cell lung carcinoma in Chinese population.
HPLC/MS analyses of diabetic RBC (zeige CACNA1C Proteine) glucose-modified DAF localized the sites of AGE modifications to K(125) adjacent to K(126), K(127) at the junction of CCPs2-3 and spatially near R(96), and R(100), all identified as being critical for DAF's function. Non-enzymatic DAF glycation de-regulated activation of systemic complement and T-cell activation.
CD55 TT genotype was linked to H7N9/H1N1pdm09 influenza severity in a large Chinese cohort.
CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (the CHAPLE syndrome) is caused by abnormal complement activation due to biallelic loss-of-function mutations in CD55.
This study demonstrates an up-regulation of complement regulatory proteins, CD35 and CD55 in HIV associated pre-eclamptic compared to normotensive pregnancy.
There is an altered pattern of CD55 and CD59 (zeige CD59 Proteine) expression on RBCs (zeige SSU1 Proteine) of SCD (zeige SCD Proteine) Patients; however, it does not seem to play a causal role in the pathophysiology of anemia, and is unlikely to be influenced by the level of erythropoietin (zeige EPO Proteine) or other inflammatory mediators.
This study indicated that the CD97 (zeige CD97 Proteine) and CD55 proteins might be reliable biomarkers to predict the metastasis status and prognosis of intrahepatic cholangiocarcinoma patients.
Expression of PBMC-DAF declined in patients both at mRNA and surface level and correlated negatively with the disease activity. Expression of IFN-gamma (zeige IFNG Proteine) also declined in patients but correlated positively with DAF and negatively with disease activity
Over expression of CD55 in brushing samples taken from Barrett's esophagus
CD133-CD55- common progenitors are the main source of CXCL12 (zeige CXCL12 Proteine) and Kitl (zeige KITLG Proteine) producing cells in the developing marrow.
these data show a key role for HIF-1alpha (zeige HIF1A Proteine) in regulating the expression of CD55 on airway epithelium.
CD55 is produced by the synovium and deposited on local collagen fiber meshwork, where it protects against immune complex-mediated arthritis.
Fibrosis in Daf1-/- mice was accompanied by high expression of alpha-smooth muscle actin (zeige ACTG2 Proteine).
the downregulation of CD55 expression precedes, and has an important role regarding, the activation of C3 in the occurrence and development of DNP.
IFN-gamma (zeige IFNG Proteine)-producing NKT (zeige CTSL1 Proteine) cells enhance C5a generation via IL-10 (zeige IL10 Proteine)-mediated inhibition of CD55 expression on neutrophils, thereby exacerbating sepsis.
CD55 downregulates CD97 (zeige CD97 Proteine) surface expression on circulating leukocytes by a process that requires physical forces.
Trypanosoma cruzi-inoculated DAF-deficient mice provide a useful model for studying T-cell mediated immunity in skeletal muscle tissues.
Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 or CD59 (zeige CD59 Proteine) showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor (zeige CHRNB1 Proteine) antibodies, and more complement deposition at the neuromuscular junction.
These data suggest that complement-independent interaction of CD55 with CD97 (zeige CD97 Proteine) is functionally relevant and involved in granulocyte homeostasis and host defense.
This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF)\; binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined.
, complement decay-accelerating factor
, Cromer blood group
, GPI anchor addition signal
, complement decay-accelerating factor, GPI-anchored
, decay accelerating factor 1
, CD55 molecule, decay accelerating factor for complement (Cromer blood group)
, decay-accelerating factor (GDab-TCS)
, decay-accelerating factor CD55
, decay accelarating factor 1
, decay accelerating factor GPI-form
, decay-accelarating factor
, glycosylphophatidylinositol-anchored form
, decay accelerating factor for complement
, decay-accelerating factor 1