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anti-Human C5A Antikörper:
anti-Rat (Rattus) C5A Antikörper:
anti-Mouse (Murine) C5A Antikörper:
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Human Polyclonal C5A Primary Antibody für IHC, ELISA - ABIN1585589
Yamamoto, Tanaka, Xin, Nishikawa, Yamazaki, Shimizu, Ogawa: Role of the BrafV637E mutation in hepatocarcinogenesis induced by treatment with diethylnitrosamine in neonatal B6C3F1 mice. in Molecular carcinogenesis 2017
Show all 4 Pubmed References
Mouse (Murine) Monoclonal C5A Primary Antibody für ELISA - ABIN2688862
Hugli: Structure and function of the anaphylatoxins. in Springer seminars in immunopathology 1984
The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.
C5a/C5aR pathway promotes gastric cancer pathogenesis by suppressing p21 (zeige CDKN1A Antikörper)/p-p21 (zeige CDKN1A Antikörper) expression via activation of PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling.
Studies indicate that the complement response lie the active fragments, C3a (zeige C3 Antikörper) and C5a, acting through their specific receptors, C3aR (zeige C3AR1 Antikörper), C5aR1 (zeige C5AR1 Antikörper) and C5aR2 to direct the cellular response to inflammation.
Data show the expression of a neoepitope which was exposed on complement C5 (zeige C5 Antikörper) (C5) after binding to eculizumab in vivo.
data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation
Increased C5a expression is associated with increased inflammation in cystic fibrosis (zeige S100A8 Antikörper).
In an arterial thrombosis model, plasminogen activator administration increased C5a levels. Overall, these findings suggest plasmin bridges thrombosis and the immune response by liberating C5a and inducing MAC assembly.
C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 (zeige IL6 Antikörper) production)
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
, C5a anaphylatoxin
, anaphylatoxin C5a analog
, complement C5