Complement Component 5 Proteine (C5)

Bezeichnung:
Complement Component 5 Proteine (C5)
Auf www.antikoerper-online.de finden Sie aktuell 19 Complement Component 5 (C5) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Complement Component 5 Antikörper (178) und Complement Component 5 Kits (67) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 269 Complement Component 5 Produkte verfügbar.
Synonyme:
C5, C5a, C5b, CPAMD4, Hc, He, LOC565774, RGD1561905
alle Proteine anzeigen Gen GeneID UniProt
C5 727 P01031
C5 362119  
C5 15139 P06684

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Am meisten referenzierte Complement Component 5 Proteine

  1. Human C5 Protein expressed in Escherichia coli (E. coli) - ABIN2003124 : Gerard, Gerard: C5A anaphylatoxin and its seven transmembrane-segment receptor. in Annual review of immunology 1994 (PubMed)
    Zeige alle 5 Referenzen für 2003124

Weitere Proteine zu Complement Component 5 Interaktionspartnern

Human Complement Component 5 (C5) Interaktionspartner

  1. data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation

  2. Increased C5a expression is associated with increased inflammation in cystic fibrosis (zeige S100A8 Proteine).

  3. In an arterial thrombosis model, plasminogen activator administration increased C5a levels. Overall, these findings suggest plasmin bridges thrombosis and the immune response by liberating C5a and inducing MAC assembly.

  4. C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 (zeige IL6 Proteine) production)

  5. C5a can induce the expression of TLR4 (zeige TLR4 Proteine) in retinal pigment epithelial cells.

  6. sublingual immunotherapy for Japanese cedar pollinosis affects levels of IL-17A (zeige IL17A Proteine) and complement components 3a and 5a

  7. These results identify complement activation product C5a as a priming signal for RPE (zeige RPE Proteine) cells that allows for subsequent inflammasome activation by stimuli such as lipofuscin-mediated photooxidative damage.

  8. a significant up-regulation (173 fold increase, p < 0.0001) in the expression of inflammatory complement component 5 (C5) in endometriosis was detected for the first time.

Mouse (Murine) Complement Component 5 (C5) Interaktionspartner

  1. n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 (zeige CASP3 Proteine) in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent.

  2. The C5a/C5aR pathway is essential for up-regulating SphK1 (zeige SPHK1 Proteine) expression through p38 MAPK (zeige MAPK14 Proteine) activation in acute liver failure.in mice.

  3. We induced anti-myeloperoxidase (zeige MPO Proteine) vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease

  4. Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17 (zeige IL17A Proteine)-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner.

  5. Data (including data from studies in knockout mice) suggest that C5aR/C5aR (zeige C5AR1 Proteine) (complement C5a/anaphylatoxin C5a Receptor) signaling pathway is involved in neurocognitive injury in uninfected pups induced by malaria in pregnancy.

  6. Carboxypeptidase B2 (zeige CPB2 Proteine) deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model.

  7. our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1 (zeige C5AR1 Proteine), which may be evaluated for potential therapeutic exploitation in ALI/ARDS.

  8. C5a signaling increases the expression of the chemokine (zeige CCL1 Proteine) monocyte chemoattractant protein-1 (zeige CCL2 Proteine) in hepatic metastases of colon cancer

  9. Properdin (zeige CFB Proteine) provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6 (zeige IL6 Proteine)-dependent manner.

  10. C5a produced during lung injury binds to C5aR (zeige C5AR1 Proteine) in alveolar macrophages, initiates downstream signaling that promotes autophagy.

Complement Component 5 (C5) Protein Überblick

Protein Überblick

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.

Alternative names and synonyms associated with Complement Component 5 (C5)

  • complement component 5 (C5)
  • similar to complement component C5-1 (LOC565774)
  • hemolytic complement (Hc)
  • C5 Protein
  • C5a Protein
  • C5b Protein
  • CPAMD4 Protein
  • Hc Protein
  • He Protein
  • LOC565774 Protein
  • RGD1561905 Protein

Bezeichner auf Proteinebene für Complement Component 5 Proteine (C5)

complement component 5 , similar to complement component C5-1 , C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 , C5a anaphylatoxin , anaphylatoxin C5a analog , complement C5 , prepro-C5 , anaphylatoxin , complement component C5 , complement C5a anaphylatoxin

GENE ID SPEZIES
464703 Pan troglodytes
565774 Danio rerio
700467 Macaca mulatta
100606437 Nomascus leucogenys
727 Homo sapiens
362119 Rattus norvegicus
100733000 Cavia porcellus
414437 Sus scrofa
512045 Bos taurus
474816 Canis lupus familiaris
417122 Gallus gallus
101121825 Ovis aries
15139 Mus musculus
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