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Human C5 ELISA Kit für Sandwich ELISA - ABIN415113
Ma, Cui, Liao, Zhao: Complement activation contributes to the injury and outcome of kidney in human anti-glomerular basement membrane disease. in Journal of clinical immunology 2013
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Human C5 ELISA Kit für Sandwich ELISA - ABIN1440228
Yang, Tsai, Chang, Chuang, Hsu, Chiang: The interaction between circulating complement proteins and cutaneous microvascular endothelial cells in the development of childhood Henoch-Schönlein Purpura. in PLoS ONE 2015
Human C5 ELISA Kit für Sandwich ELISA - ABIN2683589
Xu, Chen, Yang, Li, Zheng, Wu: C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression. in Hepatology (Baltimore, Md.) 2014
Studies indicate that the complement response lie the active fragments, C3a (zeige C3 ELISA Kits) and C5a, acting through their specific receptors, C3aR (zeige C3AR1 ELISA Kits), C5aR1 (zeige C5AR1 ELISA Kits) and C5aR2 to direct the cellular response to inflammation.
Data show the expression of a neoepitope which was exposed on complement C5 (C5) after binding to eculizumab in vivo.
data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation
Increased C5a expression is associated with increased inflammation in cystic fibrosis (zeige S100A8 ELISA Kits).
In an arterial thrombosis model, plasminogen activator administration increased C5a levels. Overall, these findings suggest plasmin bridges thrombosis and the immune response by liberating C5a and inducing MAC assembly.
C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 (zeige IL6 ELISA Kits) production)
C5a can induce the expression of TLR4 (zeige TLR4 ELISA Kits) in retinal pigment epithelial cells.
sublingual immunotherapy for Japanese cedar pollinosis affects levels of IL-17A (zeige IL17A ELISA Kits) and complement components 3a and 5a
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt (zeige AKT1 ELISA Kits) in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt (zeige AKT1 ELISA Kits) in heart.
n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 (zeige CASP3 ELISA Kits) in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent.
The C5a/C5aR pathway is essential for up-regulating SphK1 (zeige SPHK1 ELISA Kits) expression through p38 MAPK (zeige MAPK14 ELISA Kits) activation in acute liver failure.in mice.
We induced anti-myeloperoxidase (zeige MPO ELISA Kits) vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease
Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17 (zeige IL17A ELISA Kits)-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner.
Data (including data from studies in knockout mice) suggest that C5aR/C5aR (zeige C5AR1 ELISA Kits) (complement C5a/anaphylatoxin C5a Receptor) signaling pathway is involved in neurocognitive injury in uninfected pups induced by malaria in pregnancy.
Carboxypeptidase B2 (zeige CPB2 ELISA Kits) deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model.
our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1 (zeige C5AR1 ELISA Kits), which may be evaluated for potential therapeutic exploitation in ALI/ARDS.
C5a signaling increases the expression of the chemokine (zeige CCL1 ELISA Kits) monocyte chemoattractant protein-1 (zeige CCL2 ELISA Kits) in hepatic metastases of colon cancer
Properdin (zeige CFB ELISA Kits) provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6 (zeige IL6 ELISA Kits)-dependent manner.
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
complement component 5
, similar to complement component C5-1
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
, C5a anaphylatoxin
, anaphylatoxin C5a analog
, complement C5
, complement component C5
, complement C5a anaphylatoxin