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Pra1 (zeige RABAC1 Proteine) targets C3 by cleaving C3 at a unique site. This inhibited effector function of the activation fragments. The newly formed C3a-like peptide lacked the C-terminal arginine residue needed for C3a-receptor binding and activation. Pra1 (zeige RABAC1 Proteine) also bound to C3a and C3b generated by human convertases and blocked their effector functions, C3a binding to human C3a receptor, C3 antifungal activity, and C3b deposition.
data provide the first evidence that T17M rhodopsin (zeige RHO Proteine) mutant disrupts C3 secretion via the induction of ROS (zeige ROS1 Proteine) and the suppression of TWIST1 (zeige TWIST1 Proteine).
The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.
This study enclosed strong synergistic association of risk genotypes of C3 and CFH (zeige CFH Proteine) Y402H with AMD (zeige AMD1 Proteine). We also revealed synergistic influence of CCL2 (zeige CCL2 Proteine)-2518 and the at-risk genotype of the C3 in AMD (zeige AMD1 Proteine) with an estimated AP = 50.9% (adjusted AP = 24.7%). Present findings show that CCL2 (zeige CCL2 Proteine)-2518 polymorphism is not an innocent bystander (zeige SEPT1 Proteine) in AMD (zeige AMD1 Proteine) susceptibility when combined with the at-risk genotype of C3 (R102G).
Our study shows C3 to be a relatively strong susceptibility gene for advanced-type-AMD (zeige AMD1 Proteine) (exudative-and-geographic-atrophy) in an Iranian population.
BBB disruption is present in ACS (zeige PLA2G15 Proteine), and elevated levels of IL-6 (zeige IL6 Proteine) and C3 in CSF (zeige CSF2 Proteine) in diffuse NPSLE
This study uncovers the origin of the effect of ionic strength on C3d-CR2 interaction and deepens the understanding of the molecular mechanism of their interaction, which is valuable for the design of vaccines and small molecule inhibitors.
Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR (zeige C3AR1 Proteine), C5aR1 (zeige C5AR1 Proteine) and C5aR2 to direct the cellular response to inflammation.
exposure of neural stem cells to neutrophil-synthesized concentrations of C1q and C3a promoted astrogliogenesis and cell migrationtion.
THP (zeige UMOD Proteine) appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.
Data show that months after irradiation (IR) complement component 3 (C3-/-) mice made fewer errors than WT mice in a reversal learning test indicating better learning capacity in C3-/- mice after IR.
Time-lapse video microscopy established the localization of the complement anaphylatoxin C3a and its receptor on enteric neural crest cells during their migration in the embryonic gut (zeige GUSB Proteine). C3a plays a role in regulating collective and directional cell migration, and in ganglia network organization during enteric nervous system ontogenesis. It regulates cell migration in a N-cadherin (zeige CDH2 Proteine)-dependent process.
Retinal C3 was expressed by microglia/macrophages located in the outer retina in AMD (zeige AMD1 Proteine) eyes. In rodent photo-oxidative damage, C3-expressing microglia/macrophages and complement activation were located in regions of lesion expansion in the outer retina over 2 months
Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45 (zeige PTPRC Proteine)-positive cells in kidney fibrosis.
Wild-type C57BL/6 mice with pristane-induced lupus developed a strong IFN signature, which was absent in immunoglobulin-deficient (muMT), C3(-/-) , and CD18 (zeige ITGB2 Proteine)(-/-) mice. In vivo phagocytosis of dead cells was impaired in C3-deficient mice.
Study found that cancer-cell-derived C3 activates the C3a receptor in the choroid plexus epithelium to disrupt the blood-cerebrospinal fluid (CSF (zeige CSF2 Proteine)) barrier. This effect allows plasma components, including amphiregulin (zeige AREG Proteine), and other mitogens to enter the CSF (zeige CSF2 Proteine) and promote cancer cell growth.
We induced anti-myeloperoxidase (zeige MPO Proteine) vasculitis in mice and confirmed a role for complement activation by demonstrating protection in C3-deficient mice.
These data indicated that alpha7-nAChR (zeige CHRNA7 Proteine) caused the inhibition of ASPinduced activation of p38 (zeige CRK Proteine) kinase and NFkappa B to inhibit the production of MCP1 (zeige CCL2 Proteine) and keratinocytederived chemokine (zeige CCL1 Proteine).
This study provideed the evidence that C3a plays a critical role in cerebral endothelial activation and leukocyte recruitment during inflammation in the brain.
Demonstrate that cardiac Sirt1 (zeige SIRT1 Proteine) plays an essential role in caloritc restriction-induced cardioprotection against myocardial I/R injury by suppressing cardiac C3 expression.
Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR (zeige C3AR1 Proteine), revealing an unexpected role of complement proteins in early vertebrate development.
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
, C3a anaphylatoxin
, acylation-stimulating protein cleavage product
, complement C3
, complement component C3
, complement component C3a
, complement component C3b
, acylation stimulating protein
, complement component 3d
, complement factor 3
, complement component 3
, complement C3 alpha chain
, complement component C3d