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the overall architecture of Dare-C1qAgD is similar to human C1qA, residues involved in C1qBgD, C1qCgD, and CRP (zeige CRP ELISA Kits) binding are somewhat different while residues involved in IgG binding are not present in zebrafish. The structure gives insight into how human and fish C1qA evolved from an ancestral protein
C1qA globular domain (C1qAgD) was expressed, purified and crystallized.
this studies show binding of VWF (zeige VWF ELISA Kits) to C1q and thus a direct interaction between starter molecules of hemostasis and the classical pathway of complement
Cerebrospinal fluid (CSF (zeige CSF2 ELISA Kits)) soluble complement receptor 2 (sCR2 (zeige RBMS1 ELISA Kits)) levels correlated significantly both with CSF (zeige CSF2 ELISA Kits) complements C3 and C1q as well as to a disease severity measure.
This study reveled that C1QA having a central role in the bipolar disease and schizophrenia manifestation.
no significant association found to either rs15940 (C1QA) or rs172378 (C1QC (zeige C1QC ELISA Kits)) when analysed in just Parkinson disease cases , just controls or combined
Our findings showed that Brugia malayi Calreticulin (zeige CALR ELISA Kits) (BmCRT) is responsible for the prevention of classical complement pathway activation via its interaction with the first component C1q of the human host
interaction with calreticulin (zeige CALR ELISA Kits) controls the phagocyte inflammatory status
A newly characterized leech calreticulin (zeige CALR ELISA Kits) (HmCalR) has been shown to interact with C1q and participate to the HmC1q-dependent microglia accumulation.
Both CERT (zeige COL4A3BP ELISA Kits) isoforms, when immobilized, were found to bind the globular head region of C1q and to initiate the classical complement pathway. C1q binds endogenous CERTL (zeige COL4A3BP ELISA Kits) on the surface of apoptotic cells.
Most likely, C1q bridges calreticulin (zeige CALR ELISA Kits) on the parasite surface with its receptor orthologue on human placental cells, thus facilitating the first encounter between the parasite and the fetal derived placental tissue.
findings show that C1q rather than FcgammaRs controls the Ab-mediated Ag uptake and its presentation by spleen APC (zeige APC ELISA Kits) subsets to T cells
Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45 (zeige PTPRC ELISA Kits)-positive cells in kidney fibrosis.
Deleting C1qa gene significantly reduces synaptic pruning by Grn (zeige GRN ELISA Kits)(-/-) microglia and mitigates neurodegeneration, behavioral phenotypes, and premature mortality in Grn (zeige GRN ELISA Kits)(-/-) mice; results uncover a previously unrecognized role of progranulin (zeige GRN ELISA Kits) in suppressing aberrant microglia activation during aging.
developmental mechanisms of C1qa may be re-engaged during injury response
C1q is involved in the pristane-mediated enhanced inflammatory response to TLR7 (zeige TLR7 ELISA Kits) stimulation.
Data (including data from studies in mutant mice) suggest exercise prevents age-related neurovascular decline, up-regulation of C1qa, and down-regulation of astrocytic Apoe (zeige APOE ELISA Kits); this preventive effect of exercise does not occur in Apoe (zeige APOE ELISA Kits)-deficient mice.
critical role in activation of beta-catenin (zeige CTNNB1 ELISA Kits) signalling in hypertensive arterial remodelling
Data (including data on knockout mice) suggest, in absence of Trem2 (triggering receptor expressed on myeloid cells 2 (zeige TREM2 ELISA Kits)), pulmonary macrophages selectively produce elevated levels of C1q resulting in enhanced phagocytosis during pneumococcal pneumonia.
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 (zeige SOD1 ELISA Kits) mice.
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.
complement component 1, q subcomponent, alpha polypeptide
, complement C1q subcomponent subunit A
, complement component 1, q subcomponent, A chain
, complement component C1q, A chain
, complement C1qA