MUC1 ELISA Kit

Produktnummer ABIN996900

Das MUC1 ELISA Kit (ABIN996900) ist ein Colorimetric ELISA Kit zur Detektion von MUC1.

Kurzübersicht für MUC1 ELISA Kit (ABIN996900)

Target: MUC1 (Mucin 1 (MUC1))

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Detektionsbereich: 0-200 U/mL

Applikation: ELISA

Proben: Serum

Produktdetails MUC1 ELISA Kit

Untere Nachweisgrenze: 0 U/mL

Verwendungszweck: Enzyme Immunoassay for the Quantitative Measurement of Breast Cancer Antigen (CA15-3) in Human Serum.

Analytische Methode: Quantitative

Spezifität: 97 %

Sensitivität: 5 U/mL

Anwendungsinformationen

Probenmenge: 20 μL

Testdauer: 2 - 3 h

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Haltbarkeit: 12-14 months

Details zu MUC1

Target: MUC1 (Mucin 1 (MUC1))

Andere Bezeichnung: CA15-3

Hintergrund: Breast cancer is the most common life-threatening malignant lesion in women of many developed countries today, with approximately 180,000 new cases diagnosed every year. Roughly half of these newly diagnosed patients are node-negative, however 30% of these cases progress to metastatic disease. here are a number of tumor markers that can help clinicians to identify and diagnose which breast cancer patients will have aggressive disease and which will have an indolent course. These markers include estrogen and progesterone receptors, DNA ploidy and percent-S phase profile, epidermal growth factor receptor, HER-2/neu oncogene, p53 tumor suppressor gene, cathepsin D, proliferation markers and CA15-3.

CA15-3 is most useful for monitoring patients post-operatively for recurrence, particularly metastatic diseases. 96% of patients with local and systemic recurrence have elevated CA15-3, which can be used to predict recurrence earlier than radiological and clinical criteria. A 25% increase in the serum CA15-3 is associated with progression of carcinoma. A 50% decrease in serum CA15-3 is associated with response to treatment. CA15-3 are more sensitive than CEA in early detection of breast cancer recurrence. In combination with CA-125, CA15-3 has been shown to be useful in early detection of relapse of ovarian cancer. CA15-3 levels are also increased in colon, lung and hepatic tumors.

Pathways: Negative Regulation of intrinsic apoptotic Signaling