Centromere B ELISA Kit

Produktnummer ABIN930751

Diverse Spezies ELISA-Kit Colorimetric-Assay zur Quantifizierung von Diverse Spezies .

Kurzübersicht für Centromere B ELISA Kit (ABIN930751)

Target: Centromere B

Reaktivität: Diverse Spezies

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails

Analytische Methode: Quantitative

Produktmerkmale: ELISA kit for the detection of Centromere B in the research laboratory
Alternative Names: Centromere B ELISA kit

Anwendungsinformationen

Applikationshinweise: Optimal conditions to be determined by end-user

Plattentyp: Pre-coated

Testdurchführung:

AntiCentromer B is an indirect solid phase enzyme immunometric assay (ELISA). It is designed for the quantitative measurement of IgG class autoantibodies directed against Centromer B. The microplates can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8 °C.

Antigendetails

Target: Centromere B

Substanzklasse: DNA

Hintergrund: In patients suffering from CREST syndrome circulating antibodies against the centromere protein B can be detected. Up to 70 % of all CREST patients exhibit anti-centromere B autoantibodies. The determination of anti-centromere B autoantibodies is of prognostic significance in diagnosing Raynaud's phenomenon. Raynaud's phenomenon often comes out as the first symptom of scleroderma and precedes the additional manifestations by several years. Also in patients suffering from primary biliary cirrhosis (PBC) anti-centromere B antibodies can be found. PBC and CREST often overlap. Anti-centromere B are found in about 10-20 % of sera from patients with PBC preferentially identifying those patients with Raynaud's phenomenon and sclerodactyly. Along with other centromere proteins (e.g. CENPA (19 kDa), CENPC (140 kDa)) centromere protein B (80 kDa) belongs to a protein complex of the chromosomal kinetochore, the attachment site of microtuble spindles during cell division.
Synonyms: Centromere B ELISA kit.