Anti-Prothrombin IgA ELISA Kit
Reaktivität: Human
Colorimetric
Sandwich ELISA
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- Target
- Anti-Prothrombin IgA
- Reaktivität
- Human
- Nachweismethode
- Colorimetric
- Methodentyp
- Sandwich ELISA
- Applikation
- ELISA
- Analytische Methode
- Quantitative
- Produktmerkmale
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ELISA kit for the detection of Prothrombin IgA in the research laboratory
Alternative Names: Prothrombin IgA ELISA kit
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- Applikationshinweise
- Optimal conditions to be determined by end-user
- Plattentyp
- Pre-coated
- Testdurchführung
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The AntiProthrombin IgA is an indirect solid phase enzyme immunometric assay (ELISA). It is designed for the quantitative measurement of IgA class autoantibodies directed against Prothrombin. The microplate is coated with highly purified prothrombin. The microplate can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8 °C.
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- Target
- Anti-Prothrombin IgA
- Substanzklasse
- Antibody
- Hintergrund
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Prothrombin (factor II), exerts a procoagulant activity via a prothrombinase complex, triggering fibrinogen conversion to fibrin. Autoantibodies can inhibit the formation of the thrombokinase complex. This complex is formed by the binding of prothrombin to phospholipids on the damaged cell membrane where prothrombin, then, is enzymatically transformed into thrombin. Thrombin, itself, causes blood coagulation. Antibodies directed against coagulation factors, like prothrombin, are pathogenic antibodies, that circulate in the blood stream. They directly inhibit the coagulation factors, and hence prolong the coagulation time. These autoantibodies are also found in association with autoimmune diseases. The presence of antibodies to prothrombin is associated with thrombosis in patients with SLE and APS. And it was found that high autoantibody levels against prothrombin imply a risk of deep venous thrombosis and pulmonary embolism and could be involved in the development of the thrombotic processes. Furthermore, it was demonstrated that elevated levels of antibodies to prothrombin predict a risk of myocardial infarction.
Synonyms: Prothrombin IgA ELISA kit.
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