RSPO1 ELISA Kit

Produktnummer ABIN5510684

Produktdetails RSPO1 ELISA Kit

Target: RSPO1 (R-Spondin 1 (RSPO1))

Bindungsspezifität: AA 21-263

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human R-Spondin-1

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO
Immunogen sequence: S21-A263

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Produktmerkmale:

Tissue Specificity: Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. .

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu RSPO1

Target: RSPO1 (R-Spondin 1 (RSPO1))

Andere Bezeichnung: RSPO1 (RSPO1 Produkte)

Synonyme: RGD1565558 ELISA Kit, CRISTIN3 ELISA Kit, RSPO ELISA Kit, R-spondin ELISA Kit, Rspondin ELISA Kit, wu:fj81e05 ELISA Kit, zgc:92153 ELISA Kit, R-spondin 1 ELISA Kit, Rspo1 ELISA Kit, RSPO1 ELISA Kit, LOC100049655 ELISA Kit, rspo1 ELISA Kit

Hintergrund:

Protein Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. .

Background: R-spondin-1 is a secreted protein that in humans is encoded by the Rspo1 gene. It is mapped to chromosome 1p34. This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy- induced adverse effects. Alternative splicing results in multiple transcript variants.

Synonyms: R-spondin-1,Roof plate-specific spondin-1,hRspo1,RSPO1,

Full Gene Name: R-spondin-1

Cellular Localisation: Secreted . Nucleus . Seems to mainly localize to nucleoli..

UniProt: Q2MKA7