EDIL3 ELISA Kit

Produktnummer ABIN5510665

Dieses Colorimetric ELISA-Kit wurde entwickelt für die quantitative Messung von Human EDIL3.

Kurzübersicht für EDIL3 ELISA Kit (ABIN5510665)

Target: EDIL3 (DEL1) (EGF like repeats and discoidin domains 3 (DEL1))

Bindungsspezifität: AA 24-480

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails EDIL3 ELISA Kit

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human EDIL3

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO
Immunogen sequence: D24-E480

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu EDIL3

Target: EDIL3 (DEL1) (EGF like repeats and discoidin domains 3 (DEL1))

Andere Bezeichnung: EDIL3

Hintergrund:

Protein Function: Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.

Background: EDIL3, also known as DEL1, is a glycoprotein that is secreted by endothelial cells and can associate with the endothelial cell surface and the extracellular matrix. It is regulated by hypoxia or vascular injury and has been implicated in vascular remodeling during angiogenesis. The EDIL3 gene is mapped to 5q14. Human endothelial cells bind to Del1 together with the alpha-V (ITGAV)/beta-3 (ITGB3) integrin receptor. It is confirmed that adhesion of endothelial cells to Del1 is integrin mediated and that Del1 binds ITGAV/ITGB3. Functional analysis showed that both Del1 and vitronectin (VTN) stimulate endothelial cell migration. Immunoprecipitation and immunoblot analyses revealed that adhesion of endothelial cells to Del1 induces tyrosine phosphorylation of PTK2.

Synonyms: EGF-like repeat and discoidin I-like domain-containing protein 3,Developmentally-regulated endothelial cell locus 1 protein,Integrin-binding protein DEL1,EDIL3,DEL1,

Full Gene Name: EGF-like repeat and discoidin I-like domain-containing protein 3

Cellular Localisation: Secreted.

UniProt: O43854