R-Spondin 4 ELISA Kit

Produktnummer ABIN5510660

Produktdetails R-Spondin 4 ELISA Kit

Target: R-Spondin 4 (RSPO4)

Bindungsspezifität: AA 20-234

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human R-Spondin-4

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO
Immunogen sequence: L20-P234

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu R-Spondin 4

Target: R-Spondin 4 (RSPO4)

Andere Bezeichnung: RSPO4 (RSPO4 Produkte)

Synonyme: RGD1563415 ELISA Kit, RSPO4-like ELISA Kit, C20orf182 ELISA Kit, CRISTIN4 ELISA Kit, A730099F22 ELISA Kit, A930029K19Rik ELISA Kit, R-spondin 4 ELISA Kit, RSPO4 ELISA Kit, Rspo4 ELISA Kit

Hintergrund:

Protein Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. .

Background: R-spondin 4 is a protein in humans that is encoded by the RSPO4 gene. It is mapped to chromosome 20p13. This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.

Synonyms: R-spondin-4,Roof plate-specific spondin-4,hRspo4,RSPO4,C20orf182,

Full Gene Name: R-spondin-4

Cellular Localisation: Secreted.

UniProt: Q2I0M5