MUC16 ELISA Kit

Produktnummer ABIN5510649

Human MUC16 ELISA-Kit Colorimetric-Assay zur Quantifizierung von Human MUC16 und wurde in 1 Publikation erwähnt.

Kurzübersicht für MUC16 ELISA Kit (ABIN5510649)

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Bindungsspezifität: AA 21005-21992

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails MUC16 ELISA Kit

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human CA125/MUC16

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: CHO
Immunogen sequence: M21005-Q21992

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Produktmerkmale:

Tissue Specificity: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. .

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Referenzen für MUC16 ELISA Kit (ABIN5510649)

Li, Zhang, Wang, Li, Cao, Tan, Ma, Gao: "TGFβ1 in fibroblasts-derived exosomes promotes epithelial-mesenchymal transition of ovarian cancer cells." in: Oncotarget, Vol. 8, Issue 56, pp. 96035-96047, (2017) (PubMed).

Details zu MUC16

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Andere Bezeichnung: MUC16

Hintergrund:

Protein Function: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. .

Background: CA-125, also known as mucin 16 or MUC16, is a protein that in humans is encoded by the MUC16 gene. MUC16 is a member of the mucin family glycoproteins. It is a component of the ocular surface, the respiratory tract and the female reproductive tract epithelia. Since MUC16 is highly glycosylated it creates a hydrophilic environment that acts as a lubricating barrier against foreign particles and infectious agents on the apical membrane of epithelial cells. Also, the cytoplasmic tail of MUC16 has been shown to interact with cytoskeleton by binding members of the ERM protein family. The expression of mucin 16 has been shown to be altered in dry eye, cystic fibrosis, and several types of cancers.

Synonyms: Mucin-16 ,MUC-16,Ovarian cancer-related tumor marker CA125 ,CA-125 ,Ovarian carcinoma antigen CA125 ,MUC16 ,CA125 ,

Full Gene Name: Mucin-16

Cellular Localisation: Cell membrane, Single-pass type I membrane protein. Secreted, extracellular space. May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.

UniProt: Q8WXI7