FBLN3 ELISA Kit

Produktnummer ABIN5510647

This anti-FBLN3 antibody (ABIN5510647) is a antibody detecting FBLN3 in ELISA. Suitable for Human.

Kurzübersicht für FBLN3 ELISA Kit (ABIN5510647)

Target: FBLN3 (Fibulin 3 (FBLN3))

Bindungsspezifität: AA 18-493

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails FBLN3 ELISA Kit

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Fibulin-3/EFEMP1

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: CHO
Immunogen sequence: Q18-F493

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Produktmerkmale:

Tissue Specificity: In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina. .

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu FBLN3

Target: FBLN3 (Fibulin 3 (FBLN3))

Andere Bezeichnung: EFEMP1

Hintergrund:

Protein Function: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. .

Background: EGF-containing fibulin-like extracellular matrix protein 1 is a protein that in humans is encoded by the EFEMP1 gene. This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.

Synonyms: EGF-containing fibulin-like extracellular matrix protein 1,Extracellular protein S1-5,Fibrillin-like protein,Fibulin-3,FIBL-3,EFEMP1,FBLN3, FBNL,

Full Gene Name: EGF-containing fibulin-like extracellular matrix protein 1

Cellular Localisation: Secreted, extracellular space . Secreted, extracellular space, extracellular matrix . Localizes to the lamina propria underneath the olfactory epithelium..

UniProt: Q12805

Pathways: EGFR Signaling Pathway