PDCD1LG2 ELISA Kit

Produktnummer ABIN5510640

Human PDCD1LG2 ELISA-Kit Colorimetric-Assay zur Quantifizierung von Human PDCD1LG2.

Kurzübersicht für PDCD1LG2 ELISA Kit (ABIN5510640)

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Bindungsspezifität: AA 20-220

Reaktivität: Human

Nachweismethode: Colorimetric

Methodentyp: Sandwich ELISA

Applikation: ELISA

Produktdetails PDCD1LG2 ELISA Kit

Verwendungszweck: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human PD-L2/B7-DC

Marke: PicoKine™

Analytische Methode: Quantitative

Spezifität: Expression system for standard: NSO, Immunogen sequence: L20-T220

Kreuzreaktivität (Details): There is no detectable cross-reactivity with other relevant proteins.

Produktmerkmale:

Tissue Specificity: Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.

Anwendungsinformationen

Plattentyp: Pre-coated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Haltbarkeit: 12 months

Details zu PDCD1LG2

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Andere Bezeichnung: PDCD1LG2

Hintergrund:

Protein Function: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). .

Background: Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene. It is mapped to chromosome 9p24.2. PD-L2 is one of two ligands for programmed death-1 (PD-1), a member of the CD28 family of immuno-receptors. Northern blot analysis detect wide expression of PDL2, with highest levels in placenta, heart, pancreas, lung, and liver, and lower levels in spleen, lymph nodes, and thymus. PDL2 negatively regulates T cells and plays an essential role in immune tolerance.

Synonyms: Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC, CD273, PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2,

Full Gene Name: programmed cell death 1 ligand 2

Cellular Localisation: Isoform 3: Secreted

UniProt: Q9BQ51