TIMP3 ELISA Kit
Quick Overview for TIMP3 ELISA Kit (ABIN5510571)
Target
Alle TIMP3 ELISA Kits anzeigenBindungsspezifität
Reaktivität
Nachweismethode
Methodentyp
Applikation
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Verwendungszweck
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Pig porcine TIMP-3
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Marke
- PicoKine™
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Analytische Methode
- Quantitative
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Spezifität
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Expression system for standard: NSO
Immunogen sequence: C24-P211 -
Kreuzreaktivität (Details)
- There is no detectable cross-reactivity with other relevant proteins.
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Produktmerkmale
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Sequence similarities: Belongs to the protease inhibitor I35 (TIMP) family.
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Plattentyp
- Pre-coated
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
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Haltbarkeit
- 12 months
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- TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))
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Andere Bezeichnung
- TIMP3
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Hintergrund
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Protein Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Background: The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD).
Synonyms: Metalloproteinase inhibitor 3,Protein MIG-5,Tissue inhibitor of metalloproteinases 3,TIMP-3,TIMP3,
Full Gene Name: Metalloproteinase inhibitor 3
Cellular Localisation: Secreted, extracellular space, extracellular matrix. -
UniProt
- P35625
Target Alle TIMP3 ELISA Kits anzeigen
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