SensoLyte® Rh110 Plasmin Activity Assay Kit

Produktnummer ABIN1882542

Kurzübersicht für SensoLyte® Rh110 Plasmin Activity Assay Kit (ABIN1882542)

Target: Plasmin (Plasmin/fibrinolysin (PL/Fbn))

Nachweismethode: Fluorometric

Applikation: Activation (Act), Fluorescence Resonance Energy Transfer Microscopy (FRET)

Produktdetails

Marke: SensoLyte®

Produktmerkmale: The SensoLyte® Rh110 Plasmin Activity Assay Kit provides a convenient assay for high throughput screening of plasmin inhibitors and inducers or for continuous assay of plasmin activity utilizing a fluorogenic peptide. Upon enzyme cleavage, the peptide releases the Rh110 fluorophore with bright green fluorescence that can be detected at Ex/Em=496 nm/520 nm. The longer-wavelength spectra and higher extinction coefficient of the Rh110 provide greater sensitivity and less interference from reaction components.

Anwendungsinformationen

Kommentare:

FRET-based Assay Kit

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -80 °C

Informationen zur Lagerung: Store all kit components at -20 °C, except for Component C. Store Component C at -80 °C. Protect Components A and B from light and moisture. Components D and F can be stored at room temperature for convenience.

Referenzen

Ikezoe, Yang, Nishioka, Isaka, Iwabu, Sakai, Taniguchi, Honda, Yokoyama: "Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all-trans retinoic acid in acute promyelocytic leukemia cells." in: Experimental hematology, Vol. 40, Issue 6, pp. 457-65, (2012) (PubMed).

Antigendetails

Target: Plasmin (Plasmin/fibrinolysin (PL/Fbn))

Andere Bezeichnung: Plasmin

Hintergrund: Plasmin belongs to the family of serine proteases. It plays a key role in fibrinolysis by dissolving fibrin in blood clots. Besides fibrinolysis, plasmin is also involved in such physiological and pathological processes as wound healing, liver repair, and the maintenance of liver homeostasis.