SensoLyte® 520 MMP Substrate Sampler Kit

Produktnummer ABIN1882501

Kurzübersicht für SensoLyte® 520 MMP Substrate Sampler Kit (ABIN1882501)

Target: Matrix Metalloproteinase

Nachweismethode: Fluorometric

Applikation: Fluorescence Resonance Energy Transfer Microscopy (FRET)

Produktdetails

Marke: SensoLyte®

Produktmerkmale: SensoLyte® 520 MMP Substrate Sampler Kit contains a series of FRET peptide substrates for use as fluorogenic indicators to assay MMP protease activities. It provides the best solution for identifying a suitable fluorogenic substrate for a particular MMP assay. All the MMP substrates in the kit are also available in bulk packages.

Anwendungsinformationen

Kommentare:

FRET-based Assay Kit

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Handhabung: Keep Components A and B from light.

Lagerung: -20 °C

Referenzen

Wirsching, Krishnan, Florea, Frei, Krayenbühl, Hasenbach, Reifenberger, Weller, Tabatabai: "Thymosin ? 4 gene silencing decreases stemness and invasiveness in glioblastoma." in: Brain : a journal of neurology, Vol. 137, Issue Pt 2, pp. 433-48, (2014) (PubMed).

Allington, Galliher-Beckley, Schiemann: "Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4231-43, (2009) (PubMed).

Schaal, Kupfahl, Buchheidt, Neumaier, Findeisen: "Systematic identification of substrates for profiling of secreted proteases from Aspergillus species." in: Journal of microbiological methods, Vol. 71, Issue 2, pp. 93-100, (2007) (PubMed).

White, Du, Laughton, Volitakis, Sharples, Xilinas, Hoke, Holsinger, Evin, Cherny, Hill, Barnham, Li, Bush, Masters: "Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity." in: The Journal of biological chemistry, Vol. 281, Issue 26, pp. 17670-80, (2006) (PubMed).

Antigendetails

Target: Matrix Metalloproteinase

Andere Bezeichnung: MMP

Hintergrund: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. They are involved in diseases such as cancer, arthritis, asthma, angiogenesis, alopecia and metastasis. They are also identified as drug-screening targets.