This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011].
Aktuelle Publikationen für unsere Kallikrein 7 ELISA Kits
Heiker, Klöting, Kovacs, Kuettner, Sträter, Schultz, Kern, Stumvoll, Blüher, Beck-Sickinger: "Vaspin inhibits kallikrein 7 by serpin mechanism." in: Cellular and molecular life sciences : CMLS, Vol. 70, Issue 14, pp. 2569-83, (2013) (PubMed).
Sumer, Ahmad, Al-Mouzan, Al-Awamy: "Interaction of alpha-thalassemia with other hemoglobinopathies in the eastern province of Saudi Arabia." in: Birth defects original article series, Vol. 23, Issue 5A, pp. 343-7, (1988) (PubMed).