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this study shows that musculin (zeige MSC Proteine) inhibits human T-helper 17 cell response to interleukin 2 (zeige IL2 Proteine) by controlling STAT5B (zeige STAT5B Proteine) activity
STAT5 interacted with minichromosome maintenance (MCM) complex, suggesting that STAT5 directly facilitates viral DNA replication by recruiting the helicase complex of the cellular DNA replication machinery to viral DNA replication centers.
Molecular interactions of EphA4 (zeige EPHA4 Proteine), growth hormone receptor (zeige GHR Proteine), Jak2 (zeige JAK2 Proteine), and STAT5B (zeige STAT5B Proteine) have been described.
High STAT5 phosphorylation is associated with systemic lupus erythematosus.
NPM1 (zeige NPM1 Proteine) downregulation by P-STAT5 is mediated by impairing the BRCA1-BARD1 (zeige BARD1 Proteine) ubiquitin ligase, which controls the stability of NPM1 (zeige NPM1 Proteine). In turn, decreased NPM1 (zeige NPM1 Proteine) levels led to suppression of p53 (zeige TP53 Proteine) expression, resulting in enhanced cell survival.
All merkel cell carcinoma (MCC (zeige MCC Proteine)) cases with a good outcome expressed pSTAT5B, whereas all MCC (zeige MCC Proteine) cases with a poor outcome did not express pSTAT5B; hence, pSTAT5B expression may be an indicator of positive prognosis in patients with MCC (zeige MCC Proteine).
High STAT5A expression is associated with B-lymphoblastic lymphoma with inflammation.
Results provide evidence that HDAC6 (zeige HDAC6 Proteine) could regulate HMGN2 (zeige HMGN2 Proteine) acetylation levels and binding to Stat5a-responsive promoters, and therefore, Stat5a transcriptional activity in breast cancer cells.
Sustained STAT5 transcription factor (STAT5) phosphorylation is necessary to induce long-term interleukin 2 receptor subunit alpha (CD25 (zeige IL2RA Proteine)) expression in T lymphocytes.
BCR/ABL (zeige ABL1 Proteine) positively regulates the expression of EZH2 (zeige EZH2 Proteine) via STAT5 signaling.
STAT5a regulates miR (zeige MLXIP Proteine)-135a transcription by binding to both miR (zeige MLXIP Proteine)-135a-1 and miR135a-2 promoter elements
These studies establish the importance of STAT5 in macrophages during ductal morphogenesis in the mammary gland and demonstrate that altering STAT5 function in macrophages can affect the development of tissue-specific disease.
findings show that Stat5 is required for CD103 (zeige ITGAE Proteine)(+) dendritic cell and alveolar macrophage development.These findings demonstrate the critical importance of Stat5 signaling in maintaining lung homeostasis, and underscore the importance of resident macrophages in moderating tissue damage and excess inflammation.
STAT5 target genes such as Oncostatin M (zeige OSM Proteine) were highly expressed in FLT3 (zeige FLT3 Proteine)-ITD(+) myeloid but not in FLT3 (zeige FLT3 Proteine)-ITD(+) lymphoid progenitor cells; lineage-specific STAT5 activation in hematopoietic progenitor cells predicts the FLT3 (zeige FLT3 Proteine)(+)-mediated leukemic phenotype in mice.
findings reveal an essential role for STAT5 in maintaining lipid homeostasis in white adipose tissue and provide a rationale for future studies into the potential of STAT5 manipulation to improve outcomes in metabolic diseases.
deregulation of local signal transducer and activator of transcription 5 signaling augments high fat diet-induced lipid accumulation in both muscle and liver.
Data show that CUZD1 (zeige CUZD1 Proteine) interacts with a complex containing JAK1 (zeige JAK1 Proteine)/JAK2 (zeige JAK2 Proteine) and STAT5, downstream transducers of prolactin (zeige PRL Proteine) signaling in the mammary gland.
The study describes an interaction network of STAT5a/LSD1 (zeige KDM1A Proteine)/HDAC3 (zeige HDAC3 Proteine) and a dual function of LSD1 (zeige KDM1A Proteine)/HDAC3 (zeige HDAC3 Proteine) on STAT5a-dependent transcription, defined by protein-protein interactions, genomic binding localization/affinity and motifs.
this study shows that lipoxin A4 protects against LPS (zeige TLR4 Proteine)-induced sepsis by promoting the generation and migration of splenic innate response activator B cells, and the underlying molecular mechanism may be related to STAT5 activation
Study showed that suppression of STAT3 (zeige STAT3 Proteine), STAT5, and STAT6 (zeige STAT6 Proteine) and overexpression of the proapoptotic factor STAT1 (zeige STAT1 Proteine), which provides p53 (zeige TP53 Proteine)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 (zeige ERBB2 Proteine) tyrosine kinase receptor (zeige KDR Proteine) overexpression promotes neuronal survival through activation of STAT (zeige STAT1 Proteine)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (zeige STAT1 Proteine)
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found
Results indicate that SNPs in STAT5A and JAK2 (zeige JAK2 Proteine) genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
The embryonic STAT5A gene is primarily activated by maternal gene products and the most abundant STAT5A expression occurred at the 2-cell stage blastocysts.
INVESTIGATION OF STAT5A, FSHR (zeige FSHR Proteine) AND LHR (zeige LHCGR Proteine) GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
The Stat5a gene is associated with an increase in lactation of mammary gland epithelial cells.
STAT5A/AvaI polymorphism seems to be a promising indirect marker to improve milk production traits in cattle.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 (zeige FGF2 Proteine) gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
Base sequence variation in STAT5A-noncoding region was studied.
The association of fertilization rate with STAT5A polymorphisms was evaluated in ocytes. Associations were found for 6 and 2 SNP. 5 SNP showed associations with both embryonic survival and fertilization rate compared with 1 SNP.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
signal transducer and activator of transcription 5A
, signal transducer and activator of transcription 5A-like
, mammary gland factor STAT5A
, mammary gland factor
, signal transducer and activator of transcription 5
, STAT5A, Mammary Gland Factor
, transcription factor STAT5B