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Peripheral blood Tregs failed to effectively utilize IL-2 (zeige IL2 Proteine) and had relatively little STAT5 phosphorylation in active ankylosing spondylitis.
These results indicate that IL-3 (zeige IL-3 Proteine) regulates endothelial cells-extracellular vesicles release, cargo and IL-3 (zeige IL-3 Proteine) angiogenic paracrine action via STAT5.
Our finding supports that STAT3 (zeige STAT3 Proteine) was the potential treated target for breast cancer therapy, whereas STAT5A/5B/6 were potential prognostic markers for better survival of BC, providing more accurate prognosis.
Similar to normal developmental programs, oncogenic functions of STAT5 rely on molecular crosstalk with PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling for the initiation, and in some instances the progression, of breast cancer. (Review)
As targets of oncogenes with intrinsic tyrosine kinase (zeige TXK Proteine) activity, STAT3 (zeige STAT3 Proteine) and STAT5 become constitutively active in hematologic neoplasms and solid tumors, promoting cell proliferation and survival and modulating redox homeostasis via regulation xCT (zeige SLC7A11 Proteine) expression. (Review)
we demonstrated that Imatinib mesylate (IM)impaired T cell survival through the inhibition of IL-7 (zeige IL7 Proteine) and STAT5-p but not TCR signaling which remained unaffected during IM therapy. Thus, off-target inhibitory effects of IM on IL-7 (zeige IL7 Proteine) and STAT5-p explain how T cell lymphopenia occurs in patients treated with IM.
Our results suggest the regulation of STAT5A via epigenetic mechanisms during normal pregnancy and the association of STAT5A epigenetic dysregulation in pregnancy related complications
dehydrocostus lactone significantly inhibits the phosphorylation expression of Bcr/Abl (zeige ABL1 Proteine), STAT5, JAK2 (zeige JAK2 Proteine), and STAT3 (zeige STAT3 Proteine) and downstream molecules including p-CrkL (zeige CRKL Proteine), Mcl-1 (zeige MCL1 Proteine), Bcl-XL (zeige BCL2L1 Proteine), and Bcl-2 (zeige BCL2 Proteine) proteins in K562 cells.
Two p53 (zeige TP53 Proteine) binding sites were mapped in the STAT5A gene and named PBS1 and PBS2; these sites were sufficient to confer p53 (zeige TP53 Proteine) responsiveness in a luciferase reporter gene.
STAT3 (zeige STAT3 Proteine)/miR (zeige MLXIP Proteine)-211/STAT5A signaling plays a key role in mesenchymal stem cell migration.
Each mutation decreased STAT5 binding and altered IL-2 (zeige IL2 Proteine)-induced Il2ra (zeige IL2RA Proteine) gene expression, revealing that individual elements within the superenhancer were not functionally redundant and that all were required for normal gene expression.
findings indicate that STAT5 contributes to the remarkable IL-3 (zeige IL-3 Proteine)-mediated inhibition of RANKL (zeige TNFSF11 Proteine)-induced osteoclastogenesis by activating Id genes and their associated pathways.
Results suggest activation of H2AX (zeige H2AFX Proteine) via promoter demethylation in specific populations of basal mammary cells that is induced by a signal from neighboring luminal cells with hyper STAT5 activity.
On the basis of our ChIP data and these previous findings, we hypothesize that PDC (zeige PDC Proteine) may modulate STAT5's ability to regulate gene expression by controlling histone or STAT5 acetylation
STAT5 gene deletion had a minor effect on cholesterol metabolism, as evidenced by no changes in expression of cholesterol transport and cholesterol synthesis genes, and numeric changes in serum and liver cholesterol levels. These minor changes in cholesterol metabolism may not have been sufficient to influence on cholesterol crystal and gallstone formation in lithogenic diet-fed STAT5 LKO mice.
Stat5 deficiency has a strong impact upon transcriptional heterogeneity in single sorted c-Kit+Lin-Sca-1+ (KLS (zeige RPS6KB2 Proteine)) cells or CD150 (zeige SLAMF1 Proteine)+CD48 (zeige CD48 Proteine)- KLS (zeige RPS6KB2 Proteine) long-term repopulating hematopoietic stem cells.
mice carrying Stat5a/b inactivation specifically in kisspeptin cells were generated. These mutants exhibited an early onset of estrous cyclicity, indicating that STAT5 transcription factors exert an inhibitory effect on the timing of puberty.
these data suggest that ROCK2 (zeige ROCK2 Proteine) signaling plays a critical role in controlling the development of TFH cells induced by autoimmune conditions through reciprocal regulation of STAT3 (zeige STAT3 Proteine) and STAT5 activation.
Upon deletion of the STAT5 response elements from the Socs2 (zeige SOCS2 Proteine) promoter in mice, cytokine induction was abrogated, while basal activity remained intact. Our data suggest that promoter-bound STAT5 modulates cytokine responses and enhancer-bound STAT5 is mandatory for gene activation.
Instead, we find that STAT5B (zeige STAT5B Proteine) is dominant over STAT5A in CD4 (zeige CD4 Proteine)(+) 'helper' T cells for both effector and regulatory (Treg) responses and, therefore, uniquely necessary for immunological tolerance.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found
Results indicate that SNPs in STAT5A and JAK2 (zeige JAK2 Proteine) genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
The embryonic STAT5A gene is primarily activated by maternal gene products and the most abundant STAT5A expression occurred at the 2-cell stage blastocysts.
INVESTIGATION OF STAT5A, FSHR (zeige FSHR Proteine) AND LHR (zeige LHCGR Proteine) GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS
The Stat5a gene is associated with an increase in lactation of mammary gland epithelial cells.
STAT5A/AvaI polymorphism seems to be a promising indirect marker to improve milk production traits in cattle.
Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 (zeige FGF2 Proteine) gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05).
Base sequence variation in STAT5A-noncoding region was studied.
The association of fertilization rate with STAT5A polymorphisms was evaluated in ocytes. Associations were found for 6 and 2 SNP. 5 SNP showed associations with both embryonic survival and fertilization rate compared with 1 SNP.
This study indicates that CISH (zeige CISH Proteine) functions as a conserved in vivo target and regulator of STAT5 (zeige STAT5B Proteine) in the control of embryonic hematopoiesis.
study demonstrates that STAT5 (zeige STAT5B Proteine) in basophils is activated through both the IL-3 (zeige IL-3 Proteine) and the FcepsilonRI (zeige FCER1G Proteine) signaling pathway
Studies demonstrate a conserved role for SOCS1 (zeige SOCS1 Proteine) in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (zeige JAK2 Proteine)-Stat5 (zeige STAT5B Proteine) pathway.
The stat5.1 (zeige STAT5B Proteine) gene lies next to the stat3 (zeige STAT3 Proteine) gene.
STAT5 (zeige STAT5B Proteine) functions in both primitive and definitive erythropoiesis, but by different mechanisms.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
mammary gland factor STAT5A
, mammary gland factor
, signal transducer and activator of transcription 5
, STAT5A, Mammary Gland Factor
, signal transducer and activator of transcription 5A
, signal transducer and activator of transcription 5A-like
, signal transducer and activator of transcription 5B
, signal transducer and activator of transcription 5B L homeolog