STAT3 Proteine (STAT3)

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. This study demonstrates that obesity-associated inflammation and metabolic disturbances depend on interleukin-6 (zeige IL6 Proteine)/Stat3-dependent formation of a distinct natural killer population, which may provide a target for the treatment of obesity, metaflammation-associated pathologies, and diabetes.

2. These results indicate that TRPV1 (zeige TRPV1 Proteine) is important for activating proinflammatory STAT3 signaling and thermoregulation-associated brain pathways in the brain.

3. we investigated the role of alisol F and 25-anhydroalisol F in mediating mitogen-activated protein kinases (MAPKs), signal transducers, and activators of transcription 3 (STAT3) and nuclear factor kappaB (NF-kappaB (zeige NFKB1 Proteine)) pathways involved in the inflammation process of LPS (zeige TLR4 Proteine)-stimulated RAW 264.7 cells.

4. loss of FAK (zeige PTK2 Proteine) signaling during endoplasmic reticulum stress causes mitochondrial dysfunction by reducing the protective effects of mitochondrial STAT3, leading to endothelial cell death.

5. Deletion of Stat3 in the mammary glands of MMTV-Myc (zeige MYC Proteine) mice resulted in increased and earlier breast hyperplasia and expedited tumorigenesis.

6. alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2 (zeige JAK2 Proteine)-STAT3 pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .

7. Taken together, the results of our present study indicated that DHCE could inhibit cellular proliferation and induce cell apoptosis in myeloma cells mediated through different mechanisms, possibly through inhibiting the IL-6/STAT3 and ERK1/2 pathways. And it may provide a new therapeutic option for MM patients.

8. activation of oligodendroglial Stat3 is required for efficient remyelination

9. Suggest that the IL-17A (zeige IL17A Proteine)/IL-10 (zeige IL10 Proteine)/STAT3 signaling pathway plays a crucial role in the pathogenesis of hepatic fibrosis by suppressing hepatocellular autophagy and that blocking this pathway may provide therapeutic benefits for the treatment of hepatic fibrosis.

10. ginsenoside Rb2 (zeige RBL2 Proteine) inhibits osteoclast differentiation by blocking NF-kappaB (zeige NFKB1 Proteine) and STAT3 signaling pathways.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Tissue microarray immunostaining indicated active STAT3 signaling in human osteosarcoma, consistent with the observations in tumor extracellular vesicle (EV)-educated mesenchymal stem cells -treated mice

2. Overexpression of CXCR4 (zeige CXCR4 Proteine) facilitated tumor growth and angiogenesis in SGC7901 xenograft tumors, which was associated with increased levels of phospho-STAT3. CXCR4 (zeige CXCR4 Proteine) contributes to tumor angiogenesis in gastric cancer by inducing STAT3-dependent VEGF (zeige VEGFA Proteine) expression.

3. The interaction between ganlyrin and SHP-1 (zeige PTPN6 Proteine) leads to inhibition of STAT3 activation and to enhancement of TNF-alpha (zeige TNF Proteine) and IL-17 (zeige IL17A Proteine) in inflammatory cells.

4. Results suggest that mTOR (zeige FRAP1 Proteine)-STAT3-HK2 (zeige HK2 Proteine) pathway is involved in the glycolysis of HCC (zeige FAM126A Proteine) cells and STAT3 may regulate HCC (zeige FAM126A Proteine) glycolysis through HK2 (zeige HK2 Proteine) pathway.

5. Inhibition of drug resistance by apigenin is related to the suppression of the signal transducer and activator of transcription 3 (STAT3) signaling pathway

6. This study demonstrates that obesity-associated inflammation and metabolic disturbances depend on interleukin-6 (zeige IL6 Proteine)/Stat3-dependent formation of a distinct natural killer population, which may provide a target for the treatment of obesity, metaflammation-associated pathologies, and diabetes.

7. Our study showed that the expressions of HER2 (zeige ERBB2 Proteine), STAT3, and SOCS3 (zeige SOCS3 Proteine) are associated with the progression of ovarian cancer (OC), and higher expressions of HER2 (zeige ERBB2 Proteine) and STAT3 and lower expression of SOCS3 (zeige SOCS3 Proteine) predict poor prognosis of OC.

8. Molecular modelling studies of PAK1 (zeige PAK1 Proteine) with its major interacting partners RHOA (zeige RHOA Proteine) and STAT3 revealed potential network gene elements in breast invasive carcinoma.

9. Our finding supports that STAT3 was the potential treated target for breast cancer therapy, whereas STAT5A (zeige STAT5A Proteine)/5B/6 were potential prognostic markers for better survival of BC, providing more accurate prognosis.

10. Calcitriol treatment of the TL-1 (zeige TNFSF15 Proteine) cell line (model of T-LGLL) led to decreased phospho-Y701 STAT1 (zeige STAT1 Proteine) and phospho-Y705 STAT3 and increased vitamin D receptor (VDR) levels.

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Thus, activation of STAT3 and inactivation of AKT (zeige AKT1 Proteine) signaling are involved in structural regression of the corpus luteum.

2. STA3 (zeige ARHGEF3 Proteine) facilitates TLR4 (zeige TLR4 Proteine)-dependent IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine) production via IL-6 (zeige IL6 Proteine) receptor-positive feedback in endometrial cells.

3. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

4. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

5. results show for the first time that interleukin-6 (zeige IL6 Proteine) (IL), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1 (zeige STAT1 Proteine)/STAT3 proteins in bovine articular chondrocytes

6. peroxynitrite causes increased expression of VEGF (zeige VEGFA Proteine) in vascular endothelial cells by a process that requires the activation of STAT3

7. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (zeige NOX1 Proteine)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

2. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (zeige CCND2 Proteine) and PSEN1 (zeige PSEN1 Proteine) genes via a STAT3-dependent pathway

3. Studied effect of recombinant porcine leukemia inhibitory factor (zeige LIF Proteine) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (zeige FTH1 Proteine)-supplemented media.

4. Data suggest that IL-6 (interleukin 6 (zeige IL6 Proteine)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (zeige IL6 Proteine)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

5. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

6. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

7. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

8. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. This is the first report of the genetic polymorphisms of the JAK1 (zeige JAK1 Proteine) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF (zeige VEGFA Proteine) pathway in pathogenesis of psoriasis.

2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (zeige MMP2 Proteine) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (zeige CDC25A Proteine) expression during oogenesis. Accordingly, restoring Cdc25a (zeige CDC25A Proteine) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

2. PTPN9 (zeige PTPN9 Proteine) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (zeige GATA1 Proteine) and ZBP-89 (zeige ZNF148 Proteine).

3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

6. The results of this study suggested that the stat3/socs3 (zeige SOCS3 Proteine) pathway is a key response in all tissue regeneration in zebrafish.

7. stat3, a known oncogene (zeige RAB1A Proteine) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (zeige PRCP Proteine) in neighboring cells during zebrafish gastrulation.