STAT3 Proteine (STAT3)

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

• signal transducer and activator of transcription 3 (STAT3)
• signal transduction and activation of transcription 3 (stat3)
• signal transducer and activator of transcription 3 (stat3)
• signal transducer and activator of transcription 3 (Stat3)
• signal transducer and activator of transcription 3, gene 1 L homeolog (stat3.1.L)
• Alle Gen-Bezeichnungen
• signal transducer and activator of transcription 3 (acute-phase response factor) (stat3)

• 1110034C02Rik Protein
• aprf Protein
• AW109958 Protein
• hies Protein
• stat3 Protein
• Alle Synonyme
• wu:fc15d02 Protein
• wu:fl59g06 Protein
• Xstat3 Protein
• z-Stat3 Protein

signal transducer and activator of transcription 3 (acute-phase response factor) , signal transducer and activator of transcription 3 , signal transduction and activation of transcription 3 , Signal transducer and activator of transcription 3 , signal transducer and activator of transcription 3-like , acute phase response factor , acute-phase response factor , DNA-binding protein APRF , Protein Stat3 , signal transducer and activator of transcription 3.1 , stat 3