STAT3 Proteine (STAT3)

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. These data underscore a critical sex-specific role for epithelial Stat3 signaling in K-ras mutant Lung adenocarcinomas.

2. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.

3. Promoter regions of ZO-1 and SOCS3 were directly regulated by transcriptional activation of STAT3. These findings suggest that regulation of the STAT3 pathway is essential for corneal endothelial homeostasis via barrier function and may protect from various inflammatory factors.

4. Denervation-activated fibro-adipogenic progenitors exhibited persistent STAT3 activation and secreted elevated levels of IL-6, which promoted muscle atrophy and fibrosis.

5. B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.

6. the absence of epithelial Stat3 in mice leads to delayed incisor amelogenesis.

7. Study found that by promoting the phosphorylation of Stat3 Pim-3 induced the expression of Slug, Snail, and Zeb1, which enhanced epithelial-mesenchymal transition-related changes and induced melanoma migration and invasion. Exploration of the mechanism revealed that Pim-3 bound directly to Stat3 and promoted its phosphorylation.

8. PNE prevented the activation of STAT3 and NFkappaBp65 signaling.

9. The protective microRNA-199a-5p-mediated unfolded protein response in hypoxic cardiomyocytes is regulated by STAT3 pathway.

10. STAT3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice.

11. Stat3 controls reactive astrocyte dynamics with a critical role for RhoA, a key regulator of actin dynamics.

12. TNF-alpha induced autophagy in cementoblasts was dependent, or partially dependent on the activity of Stat3 signaling pathway.

13. High STAT3 expression is associated with resistance to Oncolytic Virotherapy in gliobalstoma.

14. The results suggest that BRG1 and STAT3 coordinately regulate gene clustering and up-regulate Gfap and Osmr transcription in astrocytes.

15. High STAT3 expression is associated with lung injury and inflammation.

16. data suggest that brain ischemia impairs NK-cell-mediated immune defense in the periphery, at least in part through the JAK-STAT3 pathway, which can be readdressed by modulating STAT3 activation status.

17. Notch signaling regulates cell density-dependent apoptosis through IL-6/STAT3-dependent mechanism.

18. Act1 is a negative regulator in T and B cells via direct inhibition of STAT3.

19. Data show that adult mammalian cardiomyocytes restore regenerative capacity with cell cycle reentry through STAT3 as the heart recovers from myocarditis-induced cardiac damage.

20. Genetic or pharmacologic inactivation of SHP2 promotes accumulation of JAK2 phosphorylated at Y570, reduces JAK2/STAT3 signaling, inhibits TGFbeta-induced fibroblast activation and ameliorates dermal and pulmonary fibrosis.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. These data underscore a critical sex-specific role for epithelial Stat3 signaling in K-ras mutant Lung adenocarcinomas.

2. The upregulation of miR-21 may facilitate the odontoblast differentiation of dental pulp stem cells coordinating with STAT3. The inhibition of miR-21 (anti-miR-21) decreased the activation of STAT3 as well as suppressed the marker proteins of odontoblast differentiation.

3. Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors through inhibition of STAT3. Taken together, the results indicate that rhein offers a novel blueprint for pancreatic cancer therapy, particularly when combined with EGFR inhibitors

4. ABHD11-AS1 acted as a competitive endogenous (ce) RNA to upregulate STAT3 by sponging miR-1301-3p. STAT3-induced lncRNA ABHD11-AS1 promoted papillary thyroid carcinoma progression by regulating PI3K/AKT signalling pathway and miR-1301-3p/STAT3 axis.

5. Promoter regions of ZO-1 and SOCS3 were directly regulated by transcriptional activation of STAT3. These findings suggest that regulation of the STAT3 pathway is essential for corneal endothelial homeostasis via barrier function and may protect from various inflammatory factors.

6. STAT1 Gain-of-Function and Dominant Negative STAT3 Mutations Impair IL-17 and IL-22 Immunity Associated with Chronic mucocutaneous candidiasis.

7. High STAT3 expression is associated with lower extremity deep venous thrombosis.

8. Results show that enhanced interleukin 6(IL-6)/phosphorylated STAT3 transcription factor (pSTAT3) signaling may contribute to promotion of follicular helper T (Tfh) cells Tfh cells, consequently skewing the ratio of Tfh to follicular regulatory T (Tfr) cells, which may be crucial for disease progression in rheumatoid arthritis (RA).

9. Interaction of stattic, a STAT3 inhibitor with human serum albumin: spectroscopic and computational study.

10. Phosphoproteomic analysis reveals hyperactivation of mTOR/STAT3 and LCK/Calcineurin axes in pediatric early T-cell precursor ALL.

11. LncRNA BLACAT1 contributes to the proliferation and migration of osteosarcoma cells by regulating STAT3

12. CIRP mediates the activation of STAT3-Bag-1 signaling cascade via activating the Janus kinase family proteins and NF-kappaB signaling pathways upon UV irradiation.

13. the transcription factor signal transducer and activator of transcription 3 was activated by TB-PE, and its chemical inhibition prevented the accumulation of lipid bodies and ACAT expression in macrophages. In terms of the host immune response, TB-PE-treated macrophages displayed immunosuppressive properties and bore higher bacillary loads.

14. Study reports two distinct homozygous nonsense mutations in exons 6 and 8 of ZNF341 in four consanguineous families with recurrent bacterial and fungal infections. ZNF341 mutations segregate with a phenotype resembling hyper-immunoglobulin E syndrome. Authors describe ZNF341 as a positive regulator of STAT3 expression and report the clinical and laboratory phenotype of individuals lacking ZNF341.

15. Human ZNF341 is essential for the STAT3 transcription-dependent autoinduction and sustained activity of STAT3.

16. TSLP might promote asthmatic airway remodeling via p38 MAPK-STAT3 axis activation and the crosstalk between airway epithelial cells and fibroblasts could aggravate remodeling.

17. STAT3 gene is highly expressed in acute myeloid leukemia(AML) patients, which may be used as a predictor for high-risk of AML

18. the effects of combination treatment of phosphatase activation with TKIs on cell number and activation of the signal transducer and activator of transcription 3 (STAT3) resistance pathway were determined. The combination of Rb phosphatase activation with TKIs resulted in a greater reduction in cell number compared with either treatment alone, without STAT3 pathway activation.

19. miR-216a up-regulation is associated with cisplatin resistance in ovarian cancer and this effect is mediated by PTEN. STAT3 is a regulator of miR-216a Strategies that inhibit miR-216a is a potential strategy for overcoming the cisplatin resistance in ovarian cancer.

20. In the presence of fusion protein-tyrosine kinases ITK-FER and ITK-SYK, signal transducer and activator of transcription 3 (STAT3) was highly phosphorylated and early activation antigen CD69 (CD69) was significantly elevated.

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.

2. Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.

3. STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.

4. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

5. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

6. results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes

7. role of shear flow in attenuating activation in endothelial cells

8. peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3

9. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning

2. In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 and TNF receptor-associated factor 2, suggesting mechanisms by which SOCS3 inhibits IL-6 and TNF-alpha signaling.

3. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

4. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 genes via a STAT3-dependent pathway

5. Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF-supplemented media.

6. Data suggest that IL-6 (interleukin 6) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

7. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

8. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

9. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

10. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Osteoarthritis-cartilage injuries are caused by activating JAK2/STAT3 pathway.

2. This is the first report of the genetic polymorphisms of the JAK1 and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a expression during oogenesis. Accordingly, restoring Cdc25a expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

2. PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89.

3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

6. The results of this study suggested that the stat3/socs3 pathway is a key response in all tissue regeneration in zebrafish.

7. stat3, a known oncogene and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP in neighboring cells during zebrafish gastrulation.