STAT3 Proteine (STAT3)

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. results suggest that IL-6 (zeige IL6 Proteine) gene requires up-regulation of phospho-JAK2 (zeige JAK2 Proteine)/STAT3, PACAP (zeige ADCYAP1 Proteine), and PAC1R (zeige ADCYAP1R1 Proteine) and down-regulation of the TNF-alpha (zeige TNF Proteine) gene to modulate its anticonvulsive/neuroprotective potential

2. IL-33 (zeige IL33 Proteine) may down-regulate CLDN1 (zeige CLDN1 Proteine) expression through the ERK (zeige EPHB2 Proteine)/STAT3 pathway in keratinocytes.

3. ephrin type-B receptor 1 (EphB1 (zeige EPHB1 Proteine)) is upregulated in injured motor neurons, which in turn can activate astrocytes through ephrin-B1 (zeige EFNB1 Proteine)-mediated stimulation of signal transducer and activator of transcription-3 (STAT3)

4. TRYP improves the health condition of mice with DSS (zeige PMP22 Proteine) induced colitis by regulating the TNF-&alpha (zeige TNF Proteine);/NF-κBp65 and IL-6 (zeige IL6 Proteine)/STAT3 signaling pathways via inhibiting the degradation of IκBα and the phosphorylation of STAT3.

5. Stat3 role in a regulatory module in inflammatory signaling.

6. Data identify a novel role for phospholipid phosphate phosphatase type 1 activity and hepatocyte lysophosphatidic acid levels in glucagon (zeige GCG Proteine) sensitivity via a mechanism involving STAT3.

7. MicroRNA-125a-5p mediates preadipocyte proliferation and differentiation by negatively regulating STAT3.

8. Blockade of JAK1 (zeige JAK1 Proteine)-JAK3 (zeige JAK3 Proteine) accelerated, and selective inactivation of STAT3 decelerated differentiation of progenitor cells.

9. KMT1A (zeige SUV39H1 Proteine) positively regulated the self-renewal and tumorigenicity of human Bladder cancer stem cells via KMT1A (zeige SUV39H1 Proteine)-GATA3 (zeige GATA3 Proteine)-STAT3 circuit, in which KMT1A (zeige SUV39H1 Proteine) could be a promising target for bladder cancer therapy.

10. these findings suggest that the endothelial STAT3 signaling plays an important role in limiting kidney dysfunction in ischemic acute kidney injury

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. a novel signal circuit of Stat3/Oct-4 (zeige POU5F1 Proteine)/c-Myc (zeige MYC Proteine) was identified for regulating stemness-mediated Doxorubicin resistance in triple-negative breast cancer

2. Data show that knockdown of STAT (zeige STAT1 Proteine) transcription factors STAT3 and/or STAT5 (zeige STAT5A Proteine) reduces DNA methylcytosine dioxygenase Ten-eleven translocation 1 (TET1 (zeige TET1 Proteine)) level.

3. Our results from experiments suggest that the effects of IL-17 (zeige IL17A Proteine) mediate activation of STAT3 signaling in breast cancer cells. Taken together, our study shows that myeloid-derived suppressor cells can be a new type of prognostic marker in breast cancer patients. Targeting IL-17 (zeige IL17A Proteine)/Stat3 signaling may be a promising strategy for BC treatment.

4. Among these genes, STAT3 and CDK2 (zeige CDK2 Proteine) were significantly associated with recurrence. Further study suggested that inhibition of CDK2 (zeige CDK2 Proteine) reduced invasion of Pca (zeige FLVCR1 Proteine) cell lines. The invasion ability was rescued after reintroduction of CDK2 (zeige CDK2 Proteine).

5. IL-33 (zeige IL33 Proteine) may down-regulate CLDN1 (zeige CLDN1 Proteine) expression through the ERK (zeige EPHB2 Proteine)/STAT3 pathway in keratinocytes.

6. High phosphorylated STAT3 expression is associated with pancreatic ductal adenocarcinoma.

7. In this review, the roles of STAT3 in the pathogenesis, diagnosis, treatment and prognosis of leukemia are discussed in the aspects of cell proliferation, differentiation and apoptosis, with the aim to further clarify the roles of STAT3 in leukemia, and shed light into possible novel targets and strategies for clinical diagnosis and treatment.

8. PCNA (zeige PCNA Proteine) functions as an oncogene (zeige RAB1A Proteine) in the progression of NSCLC through up-regulation of STAT3.

9. Secretome analysis revealed that Oct4 (zeige POU5F1 Proteine) upregulated interleukin 24 (IL24 (zeige IL24 Proteine)) expression through STAT3 and NFkappaB (zeige NFKB1 Proteine) signaling, and siRNA against IL24 (zeige IL24 Proteine) increased IRinduced senescence, whereas recombinant human IL24 (zeige IL24 Proteine) suppressed it. The results of the present study indicated that Oct4 (zeige POU5F1 Proteine) confers IR resistance on breast cancer cells by suppressing IRinduced premature senescence through STAT3- and NFkappaB (zeige NFKB1 Proteine)-mediated IL24 (zeige IL24 Proteine) production.

10. STAT3 signaling is hyperactivated in systemic sclerosis in a TGFbeta (zeige TGFB1 Proteine)-dependent manner

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle.

2. Thus, activation of STAT3 and inactivation of AKT (zeige AKT1 Proteine) signaling are involved in structural regression of the corpus luteum.

3. STA3 (zeige ARHGEF3 Proteine) facilitates TLR4 (zeige TLR4 Proteine)-dependent IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine) production via IL-6 (zeige IL6 Proteine) receptor-positive feedback in endometrial cells.

4. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

5. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

6. results show for the first time that interleukin-6 (zeige IL6 Proteine) (IL), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1 (zeige STAT1 Proteine)/STAT3 proteins in bovine articular chondrocytes

7. peroxynitrite causes increased expression of VEGF (zeige VEGFA Proteine) in vascular endothelial cells by a process that requires the activation of STAT3

8. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (zeige NOX1 Proteine)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning

2. In porcine circovirus type 2 subclinical infection, SOCS3 (zeige SOCS3 Proteine) interacted with STAT3 and TNF receptor-associated factor 2 (zeige TRAF2 Proteine), suggesting mechanisms by which SOCS3 (zeige SOCS3 Proteine) inhibits IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine) signaling.

3. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

4. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (zeige CCND2 Proteine) and PSEN1 (zeige PSEN1 Proteine) genes via a STAT3-dependent pathway

5. Studied effect of recombinant porcine leukemia inhibitory factor (zeige LIF Proteine) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (zeige FTH1 Proteine)-supplemented media.

6. Data suggest that IL-6 (interleukin 6 (zeige IL6 Proteine)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (zeige IL6 Proteine)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

7. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

8. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

9. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

10. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Osteoarthritis-cartilage injuries are caused by activating JAK2 (zeige JAK2 Proteine)/STAT3 pathway.

2. This is the first report of the genetic polymorphisms of the JAK1 (zeige JAK1 Proteine) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF (zeige VEGFA Proteine) pathway in pathogenesis of psoriasis.

2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (zeige MMP2 Proteine) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (zeige CDC25A Proteine) expression during oogenesis. Accordingly, restoring Cdc25a (zeige CDC25A Proteine) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

2. PTPN9 (zeige PTPN9 Proteine) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (zeige GATA1 Proteine) and ZBP-89 (zeige ZNF148 Proteine).

3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

6. The results of this study suggested that the stat3/socs3 (zeige SOCS3 Proteine) pathway is a key response in all tissue regeneration in zebrafish.

7. stat3, a known oncogene (zeige RAB1A Proteine) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (zeige PRCP Proteine) in neighboring cells during zebrafish gastrulation.