STAT3 Proteine (STAT3)

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. MicroRNA-125a-5p mediates preadipocyte proliferation and differentiation by negatively regulating STAT3.

2. Blockade of JAK1 (zeige JAK1 Proteine)-JAK3 (zeige JAK3 Proteine) accelerated, and selective inactivation of STAT3 decelerated differentiation of progenitor cells.

3. KMT1A (zeige SUV39H1 Proteine) positively regulated the self-renewal and tumorigenicity of human Bladder cancer stem cells via KMT1A (zeige SUV39H1 Proteine)-GATA3 (zeige GATA3 Proteine)-STAT3 circuit, in which KMT1A (zeige SUV39H1 Proteine) could be a promising target for bladder cancer therapy.

4. these findings suggest that the endothelial STAT3 signaling plays an important role in limiting kidney dysfunction in ischemic acute kidney injury

5. The result also reveals that Stat3 may be a crucial link between the induction of the four factors and the cell remodeling, suggesting its potential role as a target to fight melanoma.

6. Treatment with nifuroxazide inhibited the activation of STAT3, resulting in the regulation of the CD4 (zeige CD4 Proteine)+ T cells and CD4 (zeige CD4 Proteine)+CD25 (zeige IL2RA Proteine)+ T cells and reduction of interferongamma and tumor necrosis factora levels

7. STAT3 restrained cytotoxic gene expression in CD8 (zeige CD8A Proteine)+ T cells responding to viral infection in vivo.

8. STAT3 signalling in myeloid cells is deleterious in the control of infection with Mycobacterium tuberculosis.

9. It has been observed that PTEN expression downregulated by p53 (zeige TP53 Proteine) deficiency induced the activation of STAT3 in autoimmune arthritis.

10. The therapeutic function of HtrA2 (zeige HTRA2 Proteine) in inflammatory diseases is linked with Th17 development and the STAT3 pathway in splenocytes.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. our data indicate that phosphorylated -STAT3 is associated with an improved outcome in estrogen receptor (zeige ESR1 Proteine)-positive breast cancer.

2. constitutively acetylated STAT3 localizes to mitochondria, where it maintains the mitochondrial membrane potential and ATP synthesis in an active state

3. High STAT3 expression is associated with metastasis of pancreatic ductal adenocarcinoma.

4. High STAT3 expression is associated with hepatocellular carcinoma.

5. Apoptosis in rheumatoid arthritis fibroblast-like synoviocytes is induced by targeting the expression of STAT3.

6. icaritin reverses multidrug resistance in doxorubicin-resistant human osteosarcoma cells by blocking phosphorylation of signal transducer and activator of transcription 3 (STAT3).

7. Elevated S1PR1 (zeige S1PR1 Proteine) expression and STAT3 activation are also observed in human NB cells with acquired resistance to etoposide. We show in vitro and in human NB xenograft models that treatment with FTY720, an FDA-approved drug and antagonist of S1PR1 (zeige S1PR1 Proteine), dramatically sensitizes drug-resistant cells to etoposide.

8. Low STAT3 expression is associated with gastric cancer.

9. Wdrug resistance through blocking p-STAT3/p65 (zeige GORASP1 Proteine) and Bcl-2 (zeige BCL2 Proteine) activation.

10. Increased STAT3 expression and phosphorylation is associated with HPV positive cervical disease.

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Thus, activation of STAT3 and inactivation of AKT (zeige AKT1 Proteine) signaling are involved in structural regression of the corpus luteum.

2. STA3 (zeige ARHGEF3 Proteine) facilitates TLR4 (zeige TLR4 Proteine)-dependent IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine) production via IL-6 (zeige IL6 Proteine) receptor-positive feedback in endometrial cells.

3. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

4. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

5. results show for the first time that interleukin-6 (zeige IL6 Proteine) (IL), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1 (zeige STAT1 Proteine)/STAT3 proteins in bovine articular chondrocytes

6. peroxynitrite causes increased expression of VEGF (zeige VEGFA Proteine) in vascular endothelial cells by a process that requires the activation of STAT3

7. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (zeige NOX1 Proteine)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. STAT3tyr705 phosphorylation/total STAT3 protein at early reperfusion significantly increased by ischemic preconditioning

2. In porcine circovirus type 2 subclinical infection, SOCS3 (zeige SOCS3 Proteine) interacted with STAT3 and TNF receptor-associated factor 2 (zeige TRAF2 Proteine), suggesting mechanisms by which SOCS3 (zeige SOCS3 Proteine) inhibits IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine) signaling.

3. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

4. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (zeige CCND2 Proteine) and PSEN1 (zeige PSEN1 Proteine) genes via a STAT3-dependent pathway

5. Studied effect of recombinant porcine leukemia inhibitory factor (zeige LIF Proteine) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (zeige FTH1 Proteine)-supplemented media.

6. Data suggest that IL-6 (interleukin 6 (zeige IL6 Proteine)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (zeige IL6 Proteine)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

7. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

8. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

9. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

10. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. This is the first report of the genetic polymorphisms of the JAK1 (zeige JAK1 Proteine) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF (zeige VEGFA Proteine) pathway in pathogenesis of psoriasis.

2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (zeige MMP2 Proteine) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (zeige CDC25A Proteine) expression during oogenesis. Accordingly, restoring Cdc25a (zeige CDC25A Proteine) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

2. PTPN9 (zeige PTPN9 Proteine) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (zeige GATA1 Proteine) and ZBP-89 (zeige ZNF148 Proteine).

3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

6. The results of this study suggested that the stat3/socs3 (zeige SOCS3 Proteine) pathway is a key response in all tissue regeneration in zebrafish.

7. stat3, a known oncogene (zeige RAB1A Proteine) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (zeige PRCP Proteine) in neighboring cells during zebrafish gastrulation.