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The full length cDNA sequence of Atlantic salmon (Salmo salar) ssSTAT2 was determined and phylogenetic analysis of the amino acid sequence grouped this novel salmon gene to the STAT2 clade.
Surface features in the interacting domains of IRF9 (zeige IRF9 Proteine) and STAT2 have diverged to enable specific interaction between these family members and to enable the antiviral response.
Data show that RNF2 (zeige RNF2 Proteine) promotes STAT1 (zeige STAT1 Proteine)/STAT2 disassociation from DNA.
this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation, and
this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation
these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.
IFN-I can mediate ISG expression inmixed glial cell cultures (MGCs) via ISGF3 (zeige IRF9 Proteine)-independent signaling pathways but with reduced efficiency, with delayed and prolonged kinetics, and is more dependent on STAT1 (zeige STAT1 Proteine) and STAT2 than IRF9 (zeige IRF9 Proteine); and 2) signaling pathways not involving STAT1 (zeige STAT1 Proteine), STAT2, or IRF9 (zeige IRF9 Proteine) play a minor role only in mediating IFN-alpha (zeige IFNA Proteine)-stimulated genes expression in MGCs.
transcriptional activation of Adar1 (zeige ADAR Proteine) by IFN occurs in the absence of STAT1 (zeige STAT1 Proteine) by a non-canonical STAT2-dependent pathway in mouse but not human cells.
IFN-alpha (zeige IFNA Proteine)/beta is able to drive the formation of a Stat2 and IRF-9 (zeige IRF9 Proteine) complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics.
Activation of STAT2/IRF9 (zeige IRF9 Proteine) induces a prolonged ISGF3 (zeige IRF9 Proteine)-like transcriptome and generates an antiviral response.
In a mouse syngeneic tumor transplantation model STAT2 expression reduces tumor growth.
Priming cells with IFNbeta synergistically enhances IL6 (zeige IL6 Proteine) induction in response to treatments that activate NF-kappaB (zeige NFKB1 Proteine), in a process that depends upon the recruitment of STAT2, IRF9 (zeige IRF9 Proteine).
These findings suggest that IFN-a (zeige IFNA6 Proteine) can inhibit HCV replication through a STAT2-dependent but STAT1 (zeige STAT1 Proteine)-independent pathway, whereas IFN-g (zeige IFNG Proteine) induces ISG expression and inhibits HCV replication exclusively through a STAT1 (zeige STAT1 Proteine)- and STAT2-dependent pathway.
mRNA expression of survivin was positively correlated with STAT2 mRNA in psoriasis vulgaris lesion tissues
Based on the proposition that NS5 (zeige RAF1 Proteine) utilizes SIAH2 (zeige SIAH2 Proteine)-mediated proteasomal degradation of STAT2, an in-silico study was carried out to characterize the protein-protein interactions between NS5 (zeige RAF1 Proteine), SIAH2 (zeige SIAH2 Proteine) and STAT2 proteins.
The pathways related to tumorigenicity and tumor progression, STAT2 and AdipoR1 (zeige ADIPOR1 Proteine)/AMPK (zeige PRKAA1 Proteine)/SIRT1 (zeige SIRT1 Proteine) could be restrained by miR (zeige MLXIP Proteine)-3908. In conclusion, restoration of miR (zeige MLXIP Proteine)-3908 expression induced suppression of cancer progression and glioblastoma tumorigenicity.
propose that one molecule of C protein associates with the STAT1 (zeige STAT1 Proteine):STAT2 heterodimer, inducing a conformational change to an antiparallel form, which is easily dephosphorylated
highlight the existence of a STAT1 (zeige STAT1 Proteine)-independent IFN-I signaling pathway, where STAT2/IRF9 (zeige IRF9 Proteine) can potentially substitute for the role of ISGF3 (zeige STAT1 Proteine) and offer a back-up response against viral infection.
Decreased phosphorylated STAT2 expression was accompanied by increased replication of hepatitis C virus and hepatitis E virus.
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiated the inhibitory effect of IFN-alpha (zeige IFNA Proteine) on hepatocellular carcinoma cell proliferation through activation of the JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling pathway by inhibiting SOCS3 (zeige SOCS3 Proteine) expression.
While La Piedad Michoacan Mexico Virus V protein does not affect the protein levels of STAT1 (zeige STAT1 Proteine) or STAT2, it does prevent the interferon (zeige IFNA Proteine)-induced phosphorylation and nuclear translocation of STAT1 (zeige STAT1 Proteine) and STAT2 thereby inhibiting cellular responses to interferon alpha (zeige IFNA Proteine)/beta.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1 (zeige STAT1 Proteine)/STAT2 nuclear translocation.
Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1 (zeige STAT1 Proteine)/STAT2 signal transduction by inducing karyopherin-alpha1 degradation.
the majority of the STAT1 (zeige STAT1 Proteine)/STAT2/IRF9 (zeige IRF9 Proteine) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (zeige STAT1 Proteine) and, to a lesser extent, STAT2.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
, signal transducer and activator of transcription 2
, signal transducer and activator of transcription (AGAP000099-PA)
, interferon alpha induced transcriptional activator