anti-SRC (SRC) Antikörper

Mouse (Murine) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

1. Findings reveal a reciprocal feedback circuit of Cdh1 and c-Src in the crosstalk between the cell cycle machinery and the c-Src signaling pathway, regulating mammary tumorigenesis.

2. Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation.

3. c-Src-mediated regulation of Nrf2 transcriptional activity, via PKCdelta activation.

4. Results suggest that Src regulates retinal ganglion cell survival during aging in a manner that depends on Ser75 phosphorylation.

5. a previously unknown role for Src in regulating cell division orientation in relation to the pre-division geometry of mother cells, which may contribute to the misoriented cell division, is reported.

6. he ability of beta3 integrins to specifically sense local tensional organization is mostly encoded by its cytoplasmic domain and is regulated by tuning the affinity of its NPXY domains through phosphorylation by Src family kinases.

7. This study identifies a so-far undescribed mechanism of Shp1/Src modulation that promotes cell motility and that is dependent on the cPLA2 metabolite glycerophosphoinositol 4-phosphate.

8. We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.

9. findings suggest that HBc promotes tumorigenesis of hepatoma cells by enhancing the expression of total Src and the active form of the kinase and subsequently activates Src/PI3K/Akt signaling pathway, revealing novel insights into the underlying mechanisms of HBV-associated hepatocarcinogenesis.

10. Src kinase activation by nitric oxide promotes resistance to anoikis in tumor cell lines.

11. RANKL and Src has an unrecognized role in osteocyte survival.

12. These interactions are required for SRC-induced activation of VAV and the subsequent engagement of a JIP1-tethered JNK signaling module.

13. Elevated retinoic acid-inducible gene 1 (RIG-I) modulated the interaction of activated proto-oncogene c-Src (Src) and STAT3 by competitive binding to STAT3.

14. Cbl, Cbl-b, and Cbl-c have a role in protecting mammary epithelial cellsfrom proteotoxic stress-induced cell death by promoting turnover of active c-Src

15. unlike c-fos-/- mice, c-src-/- mice demonstrated activated, mature osteoblasts, and parallel layers of cement lines in the superficial bone matrix, indicating the new bones were piled up to older bone.

16. TM, especially TME45, maintains vascular integrity, at least in part, via Src signaling.

17. We conclude that pp60(Src) can directly inhibit DDAH II and this is involved in the increased ADMA levels that enhance eNOS uncoupling during the development of acute lung injury (ALI).

18. Ambra1 binds to both FAK and Src in cancer cells. When FAK is present, Ambra1 is recruited to focal adhesions, promoting FAK-regulated cancer cell direction-sensing and invasion. However, when Ambra1 cannot bind to FAK, abnormally high levels of phospho-Src and phospho-FAK accumulate at focal adhesions, positively regulating adhesion and invasive migration.

19. Thus we propose that Cx43 might enhance the activation of Nrf2/ARE pathway by means of inhibiting c-Src activity to hinder the nuclear export of Nrf2, and then reduce expression of FN, ICAM-1 and TGF-b1, ultimately attenuating renal fibrosis in diabetes.

20. Osteoprotegerin may induce podosome reassembly and peripheral adhesive structure detachment by modulating phosphorylation of Pyk2 and Src and their intracellular distribution in osteoclasts.

Fruit Fly (Drosophila melanogaster) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

1. Src overexpression alone activated the Jun N-terminal Kinase (JNK) signalling pathway to promote actin cytoskeletal and cell polarity defects and drive apoptosis in in a whole epithelial tissue context in the Drosophila eye, whereas, in cooperation with RasACT, JNK led to a loss of differentiation and an invasive phenotype.

2. Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo

3. that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction

4. Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.

5. a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.

6. Data show that the actin-Capping Protein (CP) alphabeta heterodimer, which regulates actin filament (F-actin) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK activation.

7. Dumbfounded/Neph1, a key diaphragm constituent, is a target of the Src kinase Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 tyrosine phosphorylation.

8. Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.

9. E4orf4 has a role in inducing PP2A- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster

10. Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.

11. Maternal src64 regulates microfilament contraction throughout cellularization, but that zygotic src64 makes a small, but normally nonessential, contribution during late cellularization.

12. Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin formation and Jun kinase activation in plasmatocytes.

13. Src64 acts in a cell-autonomous fashion and is likely to interact with the previously-identified linotte/derailed receptor tyrosine kinase in mushroom body development

14. In the absence of its PH domain, Tec29 constitutively localizes to ring canals, but still requires Src64 for full activation

15. Src, Jun N-terminal kinase, and STAT pathways are inhibited by Drosophila C-terminal Src kinase, which negatively regulates organ growth and cell proliferation

16. Src64 is involved in fusome development and karyosome formation during Drosophila oogenesis.

17. Results demonstrate that regulation of Src64 by Drosophila C-terminal-Src Kinase (Csk) contributes to the packaging of germline cysts by overlying somatic follicle cells during egg chamber formation.

18. Study shows that in Drosophila epithelia in situ, levels of Src signaling determine the cellular outcome of Src activation; apoptotic cell death was triggered at high Src levels; lower levels directed antiapoptotic signals while promoting proliferation.

19. Src64B is required for tracheal development and to increase the rate of adherens junction turnover.

Human V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

1. Our findings suggest a convergence point role of Rack1/Src/Anxa2 complex in the crosstalk between drug resistance and cancer aggressiveness. The interaction between Anxa2 and Rack1/Src is responsible for the association between drug resistance and invasive/metastatic potential in breast cancer cells.

2. in diseased cardiac tissue, in which Src is active, an increase in intercalated disc and intracellular localized Cx43 pY313, was observed.

3. This study identified a novel activating mutation observed clinically, W121R, that can escape down-regulation mechanisms.

4. Our work demonstrates that SRC-1-dependent epigenetic remodeling is a 'high level' regulator of the poorly differentiated state in ER-positive breast cancer

5. Both Src and MAPK are coactivated in 31% of high-grade serous ovarian cancer (HGSOC), and this associates with worse overall survival on multivariate analysis. Frequent dual kinase activation in HGSOC led us to assay the efficacy of combined Src and MEK inhibition

6. We conclude that in human osteosarcoma Saos-2 cells, Src kinase is activated during early steps of mineral formation, which leads to the reorganization of the actin cytoskeleton, whereas ROCK is engaged in MII rearrangement and vesicle release

7. SRC-1 modulated endothelial cell (EC) function and facilitated a pro-angiogenic microenvironment through PEA3 signaling; moreover, a combination of targeting SRC-1 and PEA3 signaling in glioma could be a promising strategy for suppressing tumor angiogenesis

8. Overexpression of DeltaNp63gamma modulates cell invasion by inducing targetable SRC-Slug-evoked epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma , which can be reversed by inhibitors of the SRC signaling.

9. Therefore, ANXA2 overexpression play a pivotal role in colorectal cancer invasiveness through Src/ANXA2/STAT3 pathway activation.

10. Here, we apply saturation mutagenesis and a chemical genetic method for allosterically modulating kinase global conformation to Src kinase, providing insight into known regulatory mechanisms and revealing a previously undiscovered interaction between Src's SH4 and catalytic domains.

11. Data show that inositol phosphatase SHIP2 (SHIP2) recruited src-Family tyrosine kinases Src family kinases to the fibroblast growth factor receptors (FGFRs), which promoted FGFR-mediated phosphorylation.

12. Tyrosine kinase c-Src links energy sufficiency with PRC2 overexpression via control of mRNA translation.

13. Data indicate that myelin protein zero-like 1 (PZR) may promote the invasion and migration of colorectal cancer (CRC) cells through increasing the phosphorylation of focal adhesion kinase (FAK) and protooncogene SRC (Src).

14. a previously unknown role for Src in regulating cell division orientation in relation to the pre-division geometry of mother cells, which may contribute to the misoriented cell division, is reported.

15. The data demonstrate a novel function of LOXL4 in tumor metastasis mediated by exosomes through regulation of the FAK/Src pathway and angiogenesis in hepatocellular carcinoma.

16. MerTK mediates STAT3-KRAS/SRC-signaling axis for glioma stem cell maintenance

17. Data show that severe hypoxia increases activities of AT mutated protein (ATM) and protein kinase DNA-activated catalytic subunit (DNA-PKcs) through src tyrosine kinases (Src) and AMP-activated kinase (AMPK) signaling pathways.

18. Overall, RANKL- and bone marrow stromal cell-induced drug resistance correlated with the activation of c-Src signaling pathways, which caused a decrease in Bim expression.

19. High Src family kinase expression is associated with vinorelbine resistance in lung cancer.

20. Src, a non-receptor tyrosine kinase, might provide an effective therapeutic strategy to overcome triple-negative breast cance invasion and metastasis, which are mediated via the synergistic action of the lysosomal enzyme cathepsin S (CTSS) and gelatinase MMP-9.

Cow (Bovine) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

1. RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress.

2. AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.

3. The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.

4. results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network

5. These results suggest that TGF-beta1-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src-dependent and -independent pathways.

Pig (Porcine) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

1. The findings are consistent with previous studies that indicate a link between Na,K-ATPase activity and SFK signaling.

2. Src kinase mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets

3. Expression of mutant alpha1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction

4. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.