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anti-Human SOCS3 Antikörper:
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anti-Rat (Rattus) SOCS3 Antikörper:
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Human Polyclonal SOCS3 Primary Antibody für ELISA, IF (p) - ABIN670416
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
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Human Monoclonal SOCS3 Primary Antibody für ELISA, WB - ABIN2476543
Rychlíková, Démant: Influence of non-H-2 genotype on the response to H-2-linked mixed lymphocyte reaction stimulating (MLR-S) genes. in Folia biologica 1975
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Human Polyclonal SOCS3 Primary Antibody für IHC, IHC (p) - ABIN4355049
Harris, Apolzan: Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. in Physiology & behavior 2014
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Human Monoclonal SOCS3 Primary Antibody für IF, IHC (p) - ABIN522456
Pierconti, Martini, Pinto, Cenci, Capodimonti, Calarco, Bassi, Larocca: Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior. in The Prostate 2011
Human Monoclonal SOCS3 Primary Antibody für WB - ABIN94467
Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion. in Endocrine-related cancer 2007
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Human Polyclonal SOCS3 Primary Antibody für WB - ABIN1883384
Kim, Kim, Liu, Cao, Chen: Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. in The Journal of biological chemistry 2008
Human Polyclonal SOCS3 Primary Antibody für ELISA, WB - ABIN262251
Roberts, Robb, Rakar, Hartley, Cluse, Nicola, Metcalf, Hilton, Alexander: Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. in Proceedings of the National Academy of Sciences of the United States of America 2001
Human Monoclonal SOCS3 Primary Antibody für WB - ABIN153119
Xiang, Dong, Liu, Wang, Shi, Wei, Hu, Gong: Inhibitory effects of suppressor of cytokine signaling 3 on inflammatory cytokine expression and migration and proliferation of IL-6/IFN-?-induced vascular smooth muscle cells. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2013
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq (zeige SFPQ Antikörper) and Socs3a
stat3 (zeige STAT3 Antikörper)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (zeige TRPM7 Antikörper) regulates exocrine pancreatic development via the Mg(2 (zeige MCOLN1 Antikörper)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (zeige MAPK1 Antikörper) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (zeige SOCS1 Antikörper) and SOCS3 proteins.
SOCS3 overexpression decreased JAK (zeige JAK3 Antikörper)-STAT3 (zeige STAT3 Antikörper) signaling pathway activity, declined Bcl-2 (zeige BCL2 Antikörper) expression, inhibited cell proliferation, elevated cell apoptosis, and enhanced Adriamycin sensitivity in T24 cells
miR203 expression may be upregulated by IL17 (zeige IL17A Antikörper) stimulation, and miR203 is a positive regulator of IL17induced VEGF (zeige VEGFA Antikörper) secretion.
SOCS3 DNA methylation (zeige HELLS Antikörper) is associated with body weight and moderates the effect of cumulative stress on obesity.
SOCS3 was targeted by miR30a- 5p in allergic rhinitis
Cellular viability was significantly decreased, whereas IL6 (zeige IL6 Antikörper) and TNFalpha (zeige TNF Antikörper) levels were significantly increased, following High Glucose stimulation of A549 cells. In addition, the protein levels of SOCS3, pJAK2 and pSTAT3 were significantly increased in High Glucosetreated cells.
this study shows that Nrf2 (zeige GABPA Antikörper) activation induces lipocyte phenotype in hepatic stellate cells via enhancing SOCS3-dependent feedback inhibition on JAK2 (zeige JAK2 Antikörper)/STAT3 (zeige STAT3 Antikörper) cascade
SOCS-1 (zeige SOCS1 Antikörper), SOCS-2 (zeige SOCS2 Antikörper), and SOCS-3 proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer
Our study showed that the expressions of HER2 (zeige ERBB2 Antikörper), STAT3 (zeige STAT3 Antikörper), and SOCS3 are associated with the progression of ovarian cancer (OC), and higher expressions of HER2 (zeige ERBB2 Antikörper) and STAT3 (zeige STAT3 Antikörper) and lower expression of SOCS3 predict poor prognosis of OC.
Authors found that SOCS3 and SOCS1 (zeige SOCS1 Antikörper) expression was reduced in vivo, in tumor lesions of BCC and SCC (zeige CYP11A1 Antikörper), as compared to other skin inflammatory conditions such as psoriasis, despite the high number of IL-22 (zeige IL22 Antikörper)-secreting TILs.
the presence of SOCS3 methylation is a marker to predict treatment response and prognosis in HCC (zeige FAM126A Antikörper) patients receiving TACE (zeige ADAM17 Antikörper) therapy.
In porcine circovirus type 2 subclinical infection, SOCS3 interacted with STAT3 (zeige STAT3 Antikörper) and TNF receptor-associated factor 2 (zeige TRAF2 Antikörper), suggesting mechanisms by which SOCS3 inhibits IL-6 (zeige IL6 Antikörper) and TNF-alpha (zeige TNF Antikörper) signaling.
SOCS3 is an important negative regulator of insulin (zeige INS Antikörper) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (zeige IL10 Antikörper) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
Lentivirusmediated overexpression of SOCS3 was revealed to ameliorate neutrophilic airway inflammation by inhibiting pulmonary Th17 responses in mice with chronic Pseudomonas aeruginosa lung infections.
These data demonstrate that loss of SOCS3 in cardiomyocytes promotes deoxycorticosterone-acetate -salt-induced cardiac remodeling and inflammation.
In the present study, we investigated the hypothesis that SOCS3 expression in the VMH could exert an important role regulating the metabolic changes typically observed during pregnancy and lactation.
SOCS3 was upregulated in lung CD4 (zeige CD4 Antikörper)+ T cells in a mouse model of chronic PA lung infection and exogenous SOCS3 suppressed Th17-mediated neutrophil recruitment in vitro.
findings show SOCS3 does not appear to mediate the early inflammatory or leucine-induced changes in protein synthesis in skeletal muscle
The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (zeige IL6 Antikörper) and expression of sex hormones.
High SOCS3 expression is associated with glioma.
Mechanistic analysis indicated that E47 (zeige TCF3 Antikörper) activated expression of the transcription factor Spi-B (zeige SPIB Antikörper) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (zeige FOXP3 Antikörper) expression. These findings demonstrate that the balance of Id3 (zeige ID3 Antikörper) and E47 (zeige TCF3 Antikörper) controls the maintenance of Foxp3 (zeige FOXP3 Antikörper) expression in Treg cells and, thus, contributes to Treg cell plasticity.
Our results show, for the first time, that SOCS-3 regulates leptin (zeige LEP Antikörper)-induced responses in cartilage
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3