Leptin Receptor Proteine (LEPR)

Bezeichnung:
Leptin Receptor Proteine (LEPR)
Auf www.antikoerper-online.de finden Sie aktuell 23 Leptin Receptor (LEPR) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Leptin Receptor Antikörper (262) und Leptin Receptor Kits (69) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 363 Leptin Receptor Produkte verfügbar.
Synonyme:
CD295, db, diabetes, Fa, LEP-R, LEPR, Leprb, LEPRD, LEPROT, Modb1, Ob-R, ob-rb, OB-RGRP, Ob-RM, obese-like, obl, Obr, ObRb, Obrgrp, VPS55
alle Proteine anzeigen Gen GeneID UniProt
LEPR 3953 P48357
LEPR 16847 P48356
LEPR 24536 Q62959

Weitere Synonyme anzeigen

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Am meisten referenzierte Leptin Receptor Proteine

  1. Human Leptin Receptor Protein expressed in Human Cells - ABIN2002563 : Tartaglia, Dembski, Weng, Deng, Culpepper, Devos, Richards, Campfield, Clark, Deeds, Muir, Sanker, Moriarty, Moore, Smutko, Mays, Wool, Monroe, Tepper: Identification and expression cloning of a leptin receptor, OB-R. in Cell 1996 (PubMed)
    Zeige alle 3 Referenzen für 2002563

  2. Human Leptin Receptor Protein expressed in Human - ABIN593497 : Sato, Schehr, Ikegami: Leptin does not influence surfactant synthesis in fetal sheep and mice lungs. in American journal of physiology. Lung cellular and molecular physiology 2011 (PubMed)

Weitere Proteine zu Leptin Receptor Interaktionspartnern

Human Leptin Receptor (LEPR) Interaktionspartner

  1. Leptin receptor Gln223Arg polymorphism does not appear to be related to male fertility.

  2. In tissue samples, hypoxia-inducible factor 1-alpha (zeige HIF1A Proteine) messenger RNA and protein expression of leptin (zeige LEP Proteine) and leptin receptor were high in oral squamous cell carcinoma cases. Serum leptin (zeige LEP Proteine) levels were increased in first clinical stages of the disease.

  3. LEPR polymorphisms are associated with type 2 diabetes risk. [Meta-Analysis]

  4. over-expression of LEPR, rather than that of LEP has a fundamental role in breast carcinogenesis in particular, and probably for LEP-LEPR associated tumors in general

  5. Data suggest that hypothalamic leptin/leptin (zeige LEP Proteine) receptor signaling plays a critical role in neurodevelopment, sympathetic activation, and prevention/development of hypertension. [REVIEW]

  6. leptin (zeige LEP Proteine)-LepRb plays an important role in the pathogenesis and depression in gastric cancer

  7. In 2 unrelated girls with severe obesity, three novel LEPR mutations were detected. Longitudinal growth data show normal childhood growth, and in the older girl, a normal adult height despite hypogonadotropic hypogonadism and the lack of an obvious pubertal growth spurt (zeige BPIFA1 Proteine).

  8. genetic variability in the LEPR gene is associated with idiopathic recurrent spontaneous abortion; more frequent LEPR genotype in patients - rs7516341 (nominal P=0.034, odds ratio [OR] 0.61, 95% confidence interval [CI] 0.38-0.97) and rs1137101 (nominal P=0.048, OR 1.66, 95% CI 1.00-2.80)

  9. our findings suggest that leptin (zeige LEP Proteine) promoted the proliferation, migration and invasion of gallbladder cancer (GBC) cells by increasing OB-Rb expression through the SOCS3 (zeige SOCS3 Proteine)/JAK2 (zeige JAK2 Proteine)/p-STAT3 (zeige STAT3 Proteine) signal pathway. Targeting the leptin (zeige LEP Proteine)/OB-Rb axis could be an attractive therapeutic strategy for treatment of GBC.

  10. genetic association studies in population of children (ages 5-10 years) in Poland: Data suggest that SNPs in LEPR are associated with predisposition to weight loss while engaging in lifestyle modifications for treatment of pediatric obesity in the population studied; carriers of wild-type K665N and at least one minor Q223R allele indicate greatest likelihood of losing weight.

Mouse (Murine) Leptin Receptor (LEPR) Interaktionspartner

  1. Suggest that intact endothelial leptin (zeige LEP Proteine) signaling limits neointima formation and that obesity represents a state of endothelial leptin (zeige LEP Proteine) resistance.

  2. Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA (zeige PDGFRA Proteine) signalling could be an effective way to treat bone marrow fibrosis.

  3. Leptin (zeige LEP Proteine) expression is regulated by DNA methylation (zeige HELLS Proteine) in adipocytes.

  4. Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1 (zeige PRDM1 Proteine)).

  5. LepRb preoptic area neurons are stimulatory glutamatergic neurons, contrary to prevalent models

  6. Leptin (zeige LEP Proteine) receptors on agouti-related peptide neurons modulate the onset of puberty and adult fertility.

  7. Leptin/LepR signaling regulates adipogenesis and osteogenesis by mesenchymal stromal cells in the bone marrow in response to diet and adiposity.

  8. These data show that leptin (zeige LEP Proteine) directly impairs vascular relaxation via a vascular skeletal muscle-LepR-mediated mechanism, suggesting a potential pathogenic role for leptin (zeige LEP Proteine) to increase cardiovascular risk during obesity.

  9. These mice showed an increase in FSH (zeige BRD2 Proteine) levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin (zeige LEP Proteine)-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice.

  10. we report that estradiol has minimal direct actions on LepRb cells in the mediodasal hypothalamus and that its anorexigenic effects can occur entirely independently of LepRb-STAT3 (zeige STAT3 Proteine) signaling in female mice.

Pig (Porcine) Leptin Receptor (LEPR) Interaktionspartner

  1. LEPR showed a lower variability than LEP (zeige LEP Proteine) in the different analysed populations, especially in the Iberian breed that showed no variability

  2. Superactive human leptin (zeige LEP Proteine) antagonist reverses leptin (zeige LEP Proteine)-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin (zeige LEP Proteine) receptors.

  3. The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

  4. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  5. Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

  6. Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin (zeige LEP Proteine)

  7. Leptin (zeige LEP Proteine) and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin (zeige LEP Proteine) mRNA expression as well as E and P on leptin (zeige LEP Proteine) secretion by those cells obtained in early pregnancy.

  8. These data suggest that leptin (zeige LEP Proteine) might have a direct effect on porcine follicles and plays an important role in the follicular development.

  9. Locally produced leptin (zeige LEP Proteine) plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs.

  10. results suggest the T alleles of both LEP g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake

Cow (Bovine) Leptin Receptor (LEPR) Interaktionspartner

  1. Here, the association between DGAT1 (zeige DGAT1 Proteine) K232A, SCD1 (zeige SCD Proteine) A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1 (zeige DGAT1 Proteine), SCD1 (zeige SCD Proteine), and LEPR polymorphisms were GC/GC (zeige GC Proteine), C, and C, respectively.

  2. I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression

  3. The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

  4. SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

  5. The use of leptin (zeige LEP Proteine), leptin receptor, and DGAT1 (zeige DGAT1 Proteine) polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.

  6. The leptin (zeige LEP Proteine) and receptor gene markers would be useful for marker-assisted selection.

  7. The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.

  8. The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.

  9. the possible involvement of locally produced leptin (zeige LEP Proteine)/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.

  10. findings indicate that acetate and butyrate enhance leptin (zeige LEP Proteine) expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries

Rhesus Monkey Leptin Receptor (LEPR) Interaktionspartner

  1. A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).

Horse (Equine) Leptin Receptor (LEPR) Interaktionspartner

  1. These results indicate that horse major salivary glands, like those of humans, are likely targets of leptin (zeige LEP Proteine) actions, suggesting a functional role of leptin (zeige LEP Proteine) on these glands.

Leptin Receptor (LEPR) Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).

Alternative names and synonyms associated with Leptin Receptor (LEPR)

  • leptin receptor (lepr)
  • leptin receptor (LEPR)
  • leptin receptor (Lepr)
  • leptin receptor overlapping transcript (Leprot)
  • Leptin receptor-like (LOC100351924)
  • leptin receptor-like (LOC100069504)
  • CD295 Protein
  • db Protein
  • diabetes Protein
  • Fa Protein
  • LEP-R Protein
  • LEPR Protein
  • Leprb Protein
  • LEPRD Protein
  • LEPROT Protein
  • Modb1 Protein
  • Ob-R Protein
  • ob-rb Protein
  • OB-RGRP Protein
  • Ob-RM Protein
  • obese-like Protein
  • obl Protein
  • Obr Protein
  • ObRb Protein
  • Obrgrp Protein
  • VPS55 Protein

Bezeichner auf Proteinebene für Leptin Receptor Proteine (LEPR)

OB receptor , huB219 , B219 , LEP-R , leptin receptor gene-related protein , OB-R , Leptin receptor (fatty) , cytokine receptor , leptin receptor long insert isoform , OB-R gene-related protein

GENE ID SPEZIES
724071 Xenopus (Silurana) tropicalis
3953 Homo sapiens
450207 Canis lupus familiaris
16847 Mus musculus
396836 Sus scrofa
497205 Bos taurus
24536 Rattus norvegicus
100725434 Cavia porcellus
374223 Gallus gallus
443264 Ovis aries
574126 Macaca mulatta
230514 Mus musculus
100351924 Oryctolagus cuniculus
100069504 Equus caballus
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