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Mouse (Murine) Polyclonal Leptin Receptor Primary Antibody für CyTOF, FACS - ABIN4899541
Kiguchi, Maeda, Kobayashi, Fukazawa, Kishioka: Leptin enhances CC-chemokine ligand expression in cultured murine macrophage. in Biochemical and biophysical research communications 2009
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Mouse (Murine) Polyclonal Leptin Receptor Primary Antibody für ELISA (Detection), FACS - ABIN4899540
Farr, Fraser, Wang, Jaehn, Ogrodnik, Weivoda, Drake, Tchkonia, LeBrasseur, Kirkland, Bonewald, Pignolo, Monroe, Khosla: Identification of Senescent Cells in the Bone Microenvironment. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016
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Human Monoclonal Leptin Receptor Primary Antibody für CyTOF, FACS - ABIN4899702
Francois, Roper, Goodman, Pei, Ghumman, Mourad, de Perez, Perez-Perez, Tseng, Blaser: The association of gastric leptin with oesophageal inflammation and metaplasia. in Gut 2007
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Cow (Bovine) Polyclonal Leptin Receptor Primary Antibody für IHC, ELISA - ABIN1582193
Bigford, Bracchi-Ricard, Nash, Bethea: Alterations in mouse hypothalamic adipokine gene expression and leptin signaling following chronic spinal cord injury and with advanced age. in PLoS ONE 2012
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Human Polyclonal Leptin Receptor Primary Antibody für WB - ABIN267340
Liu, Samad, Mueller: Local adipocytes enable estrogen-dependent breast cancer growth: Role of leptin and aromatase. in Adipocyte 2013
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Human Polyclonal Leptin Receptor Primary Antibody für FACS - ABIN730313
De Matteis, Grandoni, Scatà, Catizone, Reale, Crisà, Moioli: Evaluation of leptin receptor expression on buffalo leukocytes. in Veterinary immunology and immunopathology 2016
Human Polyclonal Leptin Receptor Primary Antibody für ELISA, WB - ABIN251477
Snoussi, Strosberg, Bouaouina, Ben Ahmed, Helal, Chouchane: Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. in BMC cancer 2006
Human Monoclonal Leptin Receptor Primary Antibody für FACS - ABIN4896545
Carbone, De Rosa, Carrieri, Montella, Bruzzese, Porcellini, Procaccini, La Cava, Matarese: Regulatory T cell proliferative potential is impaired in human autoimmune disease. in Nature medicine 2014
Skeletal muscle leptin (zeige LEP Antikörper) receptors are up-regulated in response to severe energy deficit.
The leptin receptor polymorphism seems to affect neuroendocrine regulation of energy balance among adolescents with obesity.
Elevated serum leptin (zeige LEP Antikörper) level could be a predictor for arterial stiffness in hypertension patients.
LEP (zeige LEP Antikörper) and LEPR single-nucleotide polymorphisms are not associated with genetic susceptibility to systemic lupus erythematosus.
Studied adiponectin (ADIPOQ), leptin (LEP (zeige LEP Antikörper)), leptin receptor (LEPR), and resistin (RETN (zeige RETN Antikörper)) single nucleotide polymorphisms and their association in obesity. Results showed that ADIPOQ 4522CLEP (zeige LEP Antikörper) 2548GRETN (zeige RETN Antikörper) 420C
Study found an association between LEPR expression and malignant behavior of upper tract urothelial carcinoma. High LEPR expression is independently associated with poor recurrence-free and progression-free survival.
Mendelian randomization study estimating the causal effect of leptin (zeige LEP Antikörper) on Alzheimer disease (AD) did not find an effect of genetically predicted circulating leptin (zeige LEP Antikörper) and sOB-R levels on AD. As such, this study suggests that leptin (zeige LEP Antikörper) is unlikely to be a major contributor to AD, although the wide confidence intervals preclude a definitive assessment.
Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin (zeige INS Antikörper) Resistance in Spanish Female Obese Children.
Leptin (zeige LEP Antikörper), and leptin receptor polymorphisms and breast cancer risk in a Chinese cohort of women.
We demonstrate that leptin (zeige LEP Antikörper) stimulates the phosphorylation of STAT3 (zeige STAT3 Antikörper) in LEPRb-transfected non-cancer stem cells (CSCs) compared with non-transfected non-CSCs. The increased expression of LEPRb and STAT3 (zeige STAT3 Antikörper) activation recapitulated the phosphorylation status of STAT3 (zeige STAT3 Antikörper) in CSCs. Our data demonstrate that LEPRb-induced STAT3 (zeige STAT3 Antikörper) activation is essential for the induction and maintenance of triple-negative breast cancer CSCs.
Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin (zeige LEP Antikörper)-receptor (Lep (zeige LEP Antikörper)/Lepr) signaling in hypothalamic neurons regulate energy metabolism; Lep (zeige LEP Antikörper)/Lepr signaling appears to up-regulate expression of Atf3 (activating transcription factor-3 (zeige ATF3 Antikörper)) in hypothalamic neurons.
Study shows that compared to the other mouse lines, db/db mice with dysfunctional leptin (zeige LEP Antikörper) receptors had a significantly longer tail flick latency after saline and buprenorphine. The results provide novel support for the interpretation that acute thermal nociception is associated with altered leptin (zeige LEP Antikörper) signaling.
The leptin-receptor mice is not a proper model for secondary osteoporosis associated with type 2 diabetes mellitus.
Data show that leptin receptor deficient (LeprNULL) mice exhibited increased body weight and food intake.
This study reports about bone quality and bone turnover mechanisms in leptin receptor-deficient animals.
Neurotensin (zeige NTS Antikörper)-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors.
Suggest that intact endothelial leptin (zeige LEP Antikörper) signaling limits neointima formation and that obesity represents a state of endothelial leptin (zeige LEP Antikörper) resistance.
Identify Lepr(+) stromal lineage cells as the origin of myofibroblasts in primary myelofibrosis and suggest that targeting PDGFRA (zeige PDGFRA Antikörper) signalling could be an effective way to treat bone marrow fibrosis.
Leptin (zeige LEP Antikörper) expression is regulated by DNA methylation (zeige HELLS Antikörper) in adipocytes.
Attenuated leptin-receptor (LEPR) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR and its downstream signaling through the protein PR/SET domain 1 (PRDM1 (zeige PRDM1 Antikörper)).
polymorphisms in the 5' regulatory region of LEPR gene are associated with meat quality traits in Berkshire pigs
study has allowed a transcriptional characterization of LEP (zeige LEP Antikörper) and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
LEPR showed a lower variability than LEP (zeige LEP Antikörper) in the different analysed populations, especially in the Iberian breed that showed no variability
Superactive human leptin (zeige LEP Antikörper) antagonist reverses leptin (zeige LEP Antikörper)-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin (zeige LEP Antikörper) receptors.
The presence of leptin (zeige LEP Antikörper) and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP (zeige LEP Antikörper)/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP (zeige LEP Antikörper)/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin (zeige LEP Antikörper)
Leptin (zeige LEP Antikörper) and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin (zeige LEP Antikörper) mRNA expression as well as E and P on leptin (zeige LEP Antikörper) secretion by those cells obtained in early pregnancy.
These data suggest that leptin (zeige LEP Antikörper) might have a direct effect on porcine follicles and plays an important role in the follicular development.
Here, the association between DGAT1 (zeige DGAT1 Antikörper) K232A, SCD1 (zeige SCD Antikörper) A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1 (zeige DGAT1 Antikörper), SCD1 (zeige SCD Antikörper), and LEPR polymorphisms were GC/GC (zeige GC Antikörper), C, and C, respectively.
I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression
The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
SNP LEP (zeige LEP Antikörper) significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
The use of leptin (zeige LEP Antikörper), leptin receptor, and DGAT1 (zeige DGAT1 Antikörper) polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.
The leptin (zeige LEP Antikörper) and receptor gene markers would be useful for marker-assisted selection.
The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.
The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.
the possible involvement of locally produced leptin (zeige LEP Antikörper)/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.
findings indicate that acetate and butyrate enhance leptin (zeige LEP Antikörper) expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries
A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
, Leptin receptor (fatty)
, leptin receptor gene-related protein
, cytokine receptor
, leptin receptor long insert isoform
, leptin receptor