anti-IL5RA (IL5RA) Antikörper

Human Interleukin 5 Receptor, alpha (IL5RA) Interaktionspartner

1. Increased activation of B-cells is present following successful Tuberculosis treatment, and the expression of FASLG and IL5RA could potentially be utilized as a signature to monitor treatment response.

2. Interleukin-5Ralpha-targeted treatments offer promises to patients with eosinophilic respiratory disorders; review

3. This is the first study to show significant associations between IL5RA SNP rs17881144, the ATTAGA haplotype, the GTAGCA haplotype, and the GCTGCA haplotype and eczema.

4. This is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis.

5. The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+197A/G (rs340833) on the susceptibility of IgAN (P<0.001). Gene-gene interaction may have some influence on the susceptibility to IgA nephropathy.

6. These findings suggest that a functional polymorphism in IL5RA may contribute to eosinophil and mast cell activation along with specific IgE responses to staphylococcal enterotoxin A in aspirin-exacerbated respiratory disease patients.

7. The study reports the crystal structure of dimeric IL-5 in complex with the IL5RA extracellular domains.

8. REVIEW: Interleukin-5 and IL-5 receptor in health and disease

9. we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha.

10. IL-5Ralpha expression on eosinophils inversely correlated with eosinophilia and was significantly elevated in patients with systemic mastocytosis without eosinophilia

11. Study of engineered deglycosylated IL-5 receptor alpha variant proves that unique carbohydrate groups in multiglycosylated receptors can be utilized asymmetrically for function.

12. Polymorphisms in IL5RA, LPL, ITGA2 and NOS3 genes were independently associated with ischemic stroke in Chinese diabetic population.

13. Increased serum level precedes the development of eczema in children

14. findings indicate that retinoids can differentially regulate expression of IL-5Ralpha and that these effects have functional consequences in vitro on eosinophil and basophil differentiation

15. findings are consistent with an airway tissue-selective expression of the IL-5 receptor that mediates IL-5-induced airway hyperresponsiveness independent of eosinophils

16. expression of membrane IL-5Ralpha on bronchoalveolar lavage eosinophils following airway Ag challenge

17. expression of membrane IL-5 receptor alpha on human eosinophils

18. IL-5 receptor expression in cultured human eosinophils is downregulated by its ligand

19. Our findings suggest that polymorphisms in IL5RA might be among the genetic risk factors for asthma development, especially in atopic populations.

20. These data argue that the charged residues of AF17121 are utilized asymmetrically in the pathway of inhibitor-receptor complex formation to deactivate the receptor function

Mouse (Murine) Interleukin 5 Receptor, alpha (IL5RA) Interaktionspartner

1. SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells.

2. Deglycosylated variant Il5ralpha has the same ligand binding affinity and biological activity as fully glycosylated IL5Ralpha, thus demonstrating a unique role for Asn196 glycosylation in IL5Ralpha function.

3. Interleukin-5 receptor alpha chain expression and splicing during brain development in mice.

4. IL-5 is not necessary for differential splicing to occur in vivo, as all three forms of the IL-5R alpha are detected in both strains of IL-5 gene-deleted mice

5. Octamer Transcription Factor 2 (Oct2) augments the ability of activated B cells to differentiate to antibody-secreting plasma cells under T cell-dependent conditions through regulation of the gene encoding the interleukin 5 receptor alpha chain.

6. We identified B-1 progenitors expressing low levels of IL-5 receptor alpha chain (IL-5Ralpha) and eosinophil progenitors expressing higher levels of IL-5Ralpha in the fetal liver

7. The murine interleukin-5 receptor alpha chain pre-mRNA is alternatively spliced, resulting in soluble isoforms lacking the transmembrane coding region which do not complex with the IL-5R beta chain.