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HEK-293 Cells IgG1 Isotyp-Kontrolle Isotype Control

IsoC IgG1 unconjugated
Pubmed (5 Referenzen)
Produktnummer ABIN2181271
$286.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target See all IgG1 products
    IgG1
    Biologische Aktivität
    Active
    Reaktivität
    Human
    Wirt
    • 204
    • 44
    • 22
    • 9
    • 3
    • 2
    • 1
    HEK-293 Cells
    Applikation
    Isotype Control (IsoC)
    Produktmerkmale
    This protein carries no "tag". The protein has a calculated MW of 26 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
    Buffer
    50 mM Tris, 100 mM Glycine, pH 7.5
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C in lyophilized state after receipt. For long term storage, upon reconstitution rhIgG1 Fc should be aliquot and store at -20°C or -80°C.
  • Buecheler, Winzer, Tonillo, Weber, Gieseler: "Impact of Payload Hydrophobicity on the Stability of Antibody-Drug Conjugates." in: Molecular pharmaceutics, Vol. 15, Issue 7, pp. 2656-2664, (2019) (PubMed).

    Tao, Zhang, Meraner, Tovaglieri, Wu, Gerhard, Zhang, Stallcup, Miao, He, Hurdle, Breault, Brass, Dong: "Frizzled proteins are colonic epithelial receptors for C. difficile toxin B." in: Nature, Vol. 538, Issue 7625, pp. 350-355, (2017) (PubMed).

    Zhou, Wang, Tong, Okamoto, Shen, Zaro: "Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery." in: Biomaterials, Vol. 117, pp. 24-31, (2017) (PubMed).

    West, Pan, Tonsing-Carter, Hernandez, Pierce, Styke, Bowie, Garcia, Kocherginsky, Conzen: "GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome." in: Molecular cancer research : MCR, Vol. 14, Issue 8, pp. 707-19, (2017) (PubMed).

    Grenga, Kwilas, Donahue, Farsaci, Hodge: "Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack." in: Journal for immunotherapy of cancer, Vol. 3, pp. 52, (2015) (PubMed).

  • Target
    IgG1
    Abstract
    IgG1 Produkte
    Synonyme
    IgG1, Igh-4, VH7183, immunoglobulin heavy constant gamma 1 (G1m marker), Ighg1
    Hintergrund
    Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
    Molekulargewicht
    26 kDa
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