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Data indicate a recurrent somatic C > T change causing a P131L mutation in the RQCD1 (Required for Cell Differentiation1 Homolog) gene identified through whole exome sequencing of 20 metastatic melanomas.
Crystal structures of the DDX6, CNOT1 and CNOT9 complexes.
Crystal structure of the DDX6, CNOT9 and CNOT1 complex.
Our findings in this study imply the functional mechanism of RQCD1 in the Akt activity regulation as a mediator in the EGFR-signaling pathway
mammalian protein is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation
CCR4 plays a role in the regulation of certain endogenous RARalpha target genes and RCD1 and CCR4 might mediate their function through their interaction with NIF-1
Report involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells.
This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene.
CCR4-NOT transcription complex subunit 9
, EPO-induced protein FL10
, cell differentiation protein RCD1 homolog
, cancer/testis antigen 129
, protein involved in sexual development
, rcd1 (required for cell differentiation) homolog 1