PMEPA1 Proteine (PMEPA1)

Bezeichnung:: Prostate Transmembrane Protein, Androgen Induced 1 Proteine (PMEPA1)

Auf www.antikoerper-online.de finden Sie aktuell 8 Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PMEPA1 Antikörper (40) und PMEPA1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 58 PMEPA1 Produkte verfügbar.

Synonyme:: 2210418I02Rik, AW455466, Erg1.2, N4wbp4, PMEPA1, Stag1, tmepai, zgc:92731

alle Proteine anzeigen	Gen	GeneID	UniProt
Ratte PMEPA1	PMEPA1	311676
	PMEPA1	56937	Q969W9
	PMEPA1	65112
Weitere Synonyme anzeigen

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Verknüpfte Pathways mit PMEPA1 Proteine

Intracellular Steroid Hormone Receptor Signaling Pathway

Weitere Produktkategorien zu PMEPA1 Protein

Weitere Proteine zu PMEPA1 Interaktionspartnern

Human Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) Interaktionspartner

JHY-A007-50 mediates the downregulation of TMEPAI expression.
describe recent progresses in the understanding of how the TMEPAI family physiologically contributes to cellular functions and diseases
binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity.
study showed that the inhibition of autophagy induced by the depletion of TMEPAI is involved in regulation of Beclin-1 (zeige BECN1 Proteine).
these findings indicated that PMEPA1 participates in TGF-beta (zeige TGFB1 Proteine)- and hypoxia-regulated gene expression networks in solid tumors and thereby may contribute to tumor progression.
the present study suggest that the upregulation of miR19a3p expression levels contributes to tumor progression and that one of its underlying mechanisms involves inhibition of PMEPA1 expression.
Sp1 (zeige PSG1 Proteine) up-regulated TMEPAI protein expression, as well as Sp1 (zeige PSG1 Proteine) promoting TMEPAI-induced cell proliferation.
PMEPA1 was upregulated in breast cancer cell lines as well as in a set of clinical invasive breast ductal carcinomas. Interestingly, depletion of PMEPA1 decreased breast cancer stem cell (CSC)-enriched populations, while ectopic overexpression of PMEPA1 increased breast CSC-enriched populations.
these data elaborated on the diverse activity among TCF (zeige HNF4A Proteine)/LEF family members with respect to the transcriptional regulation of the TMEPAI gene.
Data show that over-expressed transmembrane prostate androgen-induced protein 1 (PMEPA1) can promote cell migration and maintain the mesenchymal-like morphology of breast cancer cells.

Mouse (Murine) Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1) Interaktionspartner

binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity.
Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine)/TCF7L2 (zeige TCF7L2 Proteine) pathway is preferentially able to alter the transcriptional regulation of the TGF-beta (zeige TGFB1 Proteine)-target gene, TMEPAI.

PMEPA1 Protein Überblick

Protein Überblick

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with PMEPA1

prostate transmembrane protein, androgen induced 1 (Pmepa1)
prostate transmembrane protein, androgen induced 1 (PMEPA1)
prostate transmembrane protein, androgen induced 1 (pmepa1)
prostate transmembrane protein, androgen induced 1 L homeolog (pmepa1.L)

2210418I02Rik Protein
AW455466 Protein
Erg1.2 Protein
N4wbp4 Protein
PMEPA1 Protein
Stag1 Protein
tmepai Protein
zgc:92731 Protein

Bezeichner auf Proteinebene für PMEPA1

transmembrane prostate androgen-induced protein , transmembrane, prostate androgen induced RNA , prostate transmembrane protein, androgen induced 1 , solid tumor-associated 1 protein , NEDD4 WW domain-binding protein 4 , Nedd4 WW binding protein 4

GENE ID	SPEZIES
311676	Rattus norvegicus
428166	Gallus gallus
436853	Danio rerio
485945	Canis lupus familiaris
617469	Bos taurus
100137708	Xenopus laevis
100144523	Sus scrofa
56937	Homo sapiens
65112	Mus musculus

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