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NKX2-1 expression was upregulated in never-smokers , lung adenocarcinoma and patients with wild-type TP53. A negative correlation between NKX2-1 and miR-365 expression was found but there was no correlation between NKX2-1 and miR-33a expression. NKX2-1 expression impacts prognosis in early-stage non-small cell lung cancer patients, particularly in those with neither TP53 nor KRAS mutations.
Study shows that that NKX2-1 directly and positively regulates transcription of cyclin D1 (zeige CCND1 Proteine) in lung adenocarcinoma. Also, the expression of NKX2-1, but not cyclin D1 (zeige CCND1 Proteine), is significantly associated with metastatic incidence as an independent good prognostic factor of adenocarcinoma.
Case Report: TTF-1 expression in of a soft tissue metastasis of mediastinal non-functioning paraganglioma.
Loss of NKX2-1 is associated with cancer.
TTF-1 might be involved in lymph node metastasis of ovarian carcinomas in the presence of lymphangiogenesis
results indicate that TTF-1 expression in NECs suggests a possible role in their normal development and differentiation
Combined genomic and proteomic analyses demonstrated infrequent alteration of validated lung cancer targets but identified novel potential targets for TTF1-negative LUAD, including KEAP1 (zeige KEAP1 Proteine)/Nrf2 (zeige GABPA Proteine) and DNA repair pathways
Low expression levels of TTF-1 is associated with lung adenocarcinoma.
Immunohistochemical comparison of two TTF-1 mAbs in atypical squamous lesions and sarcomatoid carcinoma of the lung, and pleural malignant mesothelioma suggest possibility for diagnostic errors.
Because TTF-1 is not detected in the vast majority of cases using a separate antibody clone, 8G7G3/1, we conclude that aberrant staining is due to cross-reactivity to unknown antigen(s). TTF-1 positivity and even Napsin A (zeige NAPSA Proteine) positivity, therefore, cannot be used as conclusive evidence of pulmonary origin and gastrointestinal origin must be considered in the differential diagnosis
NKX2-1 is required in the embryonic septum for cholinergic system development, learning, and memory.
Our findings demonstrate that NKX2-1 overexpression converts AFE to thyroid epithelium in a developmental time-sensitive manner and suggest a general methodology for manipulation of cell-fate decisions of developmental intermediates.
NKX2-1 binding at distal regulatory elements led to a repressed epigenetic state and transcriptional repression in the ventricular zone. Conversely, NKX2-1 is required to establish a permissive chromatin state and transcriptional activation in the sub-ventricular and mantle zones.
Study shows that within the NANCI-Nkx2.1 duplex, NANCI plays an essential role in regulating tissue identity by acting as a transcriptional rheostat to buffer Nkx2.1 expression. During lung development and in adult lung homeostasis, NANCI acts in cis (zeige CISH Proteine) to positively regulate Nkx2.1, and, in turn, Nkx2.1 directly inhibits NANCI expression.
data indicate that TTF-1 interacts with PPFP to inhibit the pro-adipogenic response to pioglitazone, and that the ability of pioglitazone to decrease TTF-1 expression contributes to its pro-adipogenic action.
Identify regulatory link between Nkx2-1, miR (zeige MLXIP Proteine)-200c, and the transcription factors Nfib (zeige NFIB Proteine) and Myb (zeige MYB Proteine), adding new players to the regulatory mechanisms driven by Nkx2-1 in lung epithelial cells that may have implications in lung development and tumorigenesis.
A population of neural stem cells in the ventral region of the adult ventricular-subventricular zone expresses the transcription factor Nkx2.1 and is derived from Nkx2.1-expressing (Nkx2.1+) embryonic precursors.
We conclude that a dedicated subset of VMHVL neurons marked by ERalpha (zeige ESR1 Proteine), NKX2-1, and Tac1 (zeige TAC1 Proteine) regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.
Prototypic GPe (zeige GYPE Proteine) neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes.
Molecular characterization of disseminated tumor cells indicates that downregulation of the transcription factor Nkx2-1 precedes lung adenocarcinoma dissemination.
This studt demonistrated that the expression of Nkx2.1 is restricted to the medial prominence in dogfish.
There exists cooperation between Nodal and Hedgehog (zeige SHH Proteine) pathways in the maintenance of the anterior-dorsal hypothalamus.
hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
NK-2 homolog A
, homeobox protein NK-2 homolog A
, homeobox protein Nkx-2.1
, thyroid nuclear factor 1
, thyroid transcription factor 1
, homeodomain protein NKx2.1
, NK2 homeobox 1
, thyroid-specific enhancer-binding protein
, thyroid transcription factor 1 TTF-1 NK-2
, thyroid transcription factor-1
, thyroid transcription factor 1a
, Homeobox protein Nkx-2.1
, LOW QUALITY PROTEIN: homeobox protein Nkx-2.1
, Thyroid nuclear factor 1
, Thyroid transcription factor 1