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anti-Rat (Rattus) NCOA4 Antikörper:
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Human Monoclonal NCOA4 Primary Antibody für IF, ELISA - ABIN521736
Poola, Abraham, Marshalleck, Yue, Fu, Viswanath, Sharma, Hill, Dewitty, Bonney: Molecular constitution of breast but not other reproductive tissues is rich in growth promoting molecules: a possible link to highest incidence of tumor growths. in FEBS letters 2009
NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress.
The H-ferritin could bind up to 24 NCOA4(383-522) fragments forming highly stable and insoluble complexes. The binding was partially inhibited only by Fe(II) among the various divalent metal ions analyzed. The iron-dependent, highly-specific formation of the remarkably stable H-ferritin-NCOA4 complex shown in this work may be important for the characterization of the mechanism of ferritinophagy.
the ATG5 (zeige ATG5 Antikörper)-ATG7 (zeige ATG7 Antikörper)-NCOA4 autophagic pathway has a role in ferroptosis
Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.
Studies indicate nuclear receptor coactivator 4 (NcoA4) as a coactivator for a variety of nuclear receptors.
provide a new mechanism for selective autophagy of ferritin (zeige FTL Antikörper) and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo
RET (zeige RET Antikörper)/PTC3 gene rearrangements are the most prevalent form of rearrangements in papillary thyroid carcinomas of Chennai population.
identification of NCOA4 as a selective cargo receptor for autophagic turnover of ferritin (zeige FTL Antikörper) (ferritinophagy), which is critical for iron homeostasis, and provides a resource for further dissection of autophagosomal cargo-receptor connectivity
mechanism dissection shows that KLK2 (zeige KLK2 Antikörper) may cooperate with the AR coregulator, ARA70, to enhance AR transactivation that may result in alteration of prostate cancer formation
Data indicate that the increase in prostate cancer (PC) risk associated with rs10993994:C>T is likely mediated by the variant's effect of MSMB (zeige MSMB Antikörper)-encoded protein PSP94 (zeige MSMB Antikörper) expression; however, this effect does not extend to NCOA4 in the data.
These studies demonstrate the importance of ferritin (zeige FTL Antikörper) for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 (zeige PCBP1 Antikörper) and NCOA4 in mediating iron flux through ferritin (zeige FTL Antikörper).
NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.
Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor (zeige AHR Antikörper), during development.
Data suggest that myostatin (zeige MSTN Antikörper) decreases the activity of androgen receptors (AR) by down-regulating the expression of ARA70, a known stimulating co-factor of AR
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
nuclear receptor coactivator 4
, Nuclear receptor coactivator 4
, 70 kDa AR-activator
, 70 kDa androgen receptor coactivator
, RET-activating gene ELE1
, androgen receptor-associated protein of 70 kDa
, ret fused