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Human Polyclonal CARM1 Primary Antibody für ICC, IF - ABIN152377
Harrison, Tang, Dowhan: Protein arginine methyltransferase 6 regulates multiple aspects of gene expression. in Nucleic acids research 2010
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Human Monoclonal CARM1 Primary Antibody für ICC, FACS - ABIN969002
Fauquier, Duboé, Joré, Trouche, Vandel: Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
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Human Polyclonal CARM1 Primary Antibody für IF (p), IHC (p) - ABIN763061
Wang, Cui, Wen, Guo, Zhang, Chen: Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. in Oncology letters 2017
Human Polyclonal CARM1 Primary Antibody für WB - ABIN4287938
Herrmann, Pably, Eckerich, Bedford, Fackelmayer: Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. in Journal of cell science 2009
Human Polyclonal CARM1 Primary Antibody für WB - ABIN2668761
Mann, Cortez, Vadlamudi: PELP1 oncogenic functions involve CARM1 regulation. in Carcinogenesis 2013
The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3beta/beta-Catenin (zeige CTNNB1 Antikörper)/cyclinD1 Signaling Pathway
The CARM1-PKM2 axis serves as a metabolic reprogramming mechanism in tumorigenesis.
Arginine (di)methylated human leukocyte antigen class I peptides, which are asymmetrically dimethylated, most likely by CARM1, are favorably presented by HLA-B*07.
Estrogen receptor (zeige ESR1 Antikörper) recruits steroid receptor coactivator (zeige SRA1 Antikörper)-3 primary coactivator and secondary coactivators, p300/CBP (zeige CREBBP Antikörper) and CARM1 to regulate genetic transcription.
Arginine methylation of MDH1 (zeige MDH1 Antikörper) by CARM1 regulates cellular redox homeostasis and suppresses glutamine (zeige GFPT1 Antikörper) metabolism of pancreatic cancer.
Here, the crystal structures of human CARM1 with the S-adenosylmethione (SAM (zeige TTN Antikörper)) mimic sinefungin and three different peptide sequences from histone H3 (zeige HIST3H3 Antikörper) and PABP1 (zeige PABPC1 Antikörper) are presented, with both nonmethylated and singly methylated arginine residues exemplified.
CARM1 associates with major nonsense-mediated mRNA decay factor UPF1 (zeige UPF1 Antikörper) and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.
Monitoring of the CARM1-dependent production of monomethylated and dimethylated peptides over time by self-assembled monolayer and matrix-assisted laser desorption ionization mass spectrometry revealed that methylation by CARM1 is distributive.
no obvious association of CARM1 isoform expression and clinical correlates in breast cancer
disruption of CARM1 enhances the nuclear retention of mRNAs containing IRAlus
Study describes peptide-based transition state mimics that form stable complexes with CARM1 resulting in high-resolution co-crystal structures. The findings provide an exciting approach to understanding protein arginine methyltransferase (PRMT) substrate recognition and the regulation of arginine methylation.
CARM1 promotes EZH2 (zeige EZH2 Antikörper)-mediated silencing of EZH2 (zeige EZH2 Antikörper)/BAF155 (zeige SMARCC1 Antikörper) target tumor suppressor genes by methylating BAF155 (zeige SMARCC1 Antikörper).
These observations demonstrate that oxidative stress destabilizes PRMT4 via GSK-3beta signaling to impede lung epithelial cell migration that may hinder the lung repair and regeneration process.
AMPK deficiency results in nuclear CARM1 decrease mediated in part by SKP2, contributing to autophagy dysfunction in the aged heart.
Study identifies CARM1, which methylates histone H3 (zeige HIST3H3 Antikörper) at arginine 26 (H3R26), as an upstream regulator of Sox21 (zeige SOX21 Antikörper) expression. These results indicate that heterogeneity in gene expression patterns biases cell fate in the mouse embryo as early as the 4-cell stage.
findings demonstrate that CARM1-dependent histone arginine methylation is a crucial nuclear event in autophagy, and identify a new signalling axis of AMPK (zeige PRKAA1 Antikörper)-SKP2-CARM1 in the regulation of autophagy induction after nutrient starvation
CARM1 haploinsufficiency impairs transdifferentiation and wound healing in a mouse model.
PRMT4 might be a key regulator of high-glucose-induced insulin (zeige INS Antikörper) secretion from pancreatic beta cells via H3R17 methylation.
Data show that the methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1; PRMT4) methylated Notch (zeige NOTCH1 Antikörper) intracellular domain (NICD (zeige NOTCH1 Antikörper)) at five conserved arginine residues.
we identify BAF155 (zeige SMARCC1 Antikörper) as a substrate for arginine methyltransferase CARM1.
a combinatorial role of PRMT4/CARM1 and PRMT5 (zeige PRMT5 Antikörper) for proper myogenesis in zebrafish
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002
histone-arginine methyltransferase CARM1
, protein arginine N-methyltransferase 4
, coactivator-associated arginine methyltransferase 1
, protein arginine methyltransferase