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anti-Human CARM1 Antikörper:
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Human Polyclonal CARM1 Primary Antibody für ICC, IF - ABIN152377
Harrison, Tang, Dowhan: Protein arginine methyltransferase 6 regulates multiple aspects of gene expression. in Nucleic acids research 2010
Show all 6 Pubmed References
Human Monoclonal CARM1 Primary Antibody für ICC, FACS - ABIN969002
Fauquier, Duboé, Joré, Trouche, Vandel: Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Show all 3 Pubmed References
Human Polyclonal CARM1 Primary Antibody für WB - ABIN2668761
Mann, Cortez, Vadlamudi: PELP1 oncogenic functions involve CARM1 regulation. in Carcinogenesis 2013
Human Polyclonal CARM1 Primary Antibody für WB - ABIN4287938
Herrmann, Pably, Eckerich, Bedford, Fackelmayer: Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. in Journal of cell science 2009
Human Polyclonal CARM1 Primary Antibody für IF (p), IHC (p) - ABIN763061
Wang, Cui, Wen, Guo, Zhang, Chen: Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. in Oncology letters 2017
N-terminal EVH1 domain of CARM1 is necessary and sufficient for substrate recognition and is required for methylation of most CARM1 substrates.
SKP2 promotes HCC progression and its nuclear functions of autophagy induction with CARM1 and AMPK, which may provide a potential target for HCC therapy.
The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3beta/beta-Catenin/cyclinD1 Signaling Pathway
The CARM1-PKM2 axis serves as a metabolic reprogramming mechanism in tumorigenesis.
Arginine (di)methylated human leukocyte antigen class I peptides, which are asymmetrically dimethylated, most likely by CARM1, are favorably presented by HLA-B*07.
Estrogen receptor recruits steroid receptor coactivator-3 primary coactivator and secondary coactivators, p300/CBP and CARM1 to regulate genetic transcription.
Arginine methylation of MDH1 by CARM1 regulates cellular redox homeostasis and suppresses glutamine metabolism of pancreatic cancer.
Here, the crystal structures of human CARM1 with the S-adenosylmethione (SAM) mimic sinefungin and three different peptide sequences from histone H3 and PABP1 are presented, with both nonmethylated and singly methylated arginine residues exemplified.
CARM1 associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.
Monitoring of the CARM1-dependent production of monomethylated and dimethylated peptides over time by self-assembled monolayer and matrix-assisted laser desorption ionization mass spectrometry revealed that methylation by CARM1 is distributive.
no obvious association of CARM1 isoform expression and clinical correlates in breast cancer
disruption of CARM1 enhances the nuclear retention of mRNAs containing IRAlus
Data indicate that coactivator-associated arginine methyltransferase 1 (CARM1) regulates neural differentiation through Nanog homeobox protein and microRNA miR92a.
Like insulin, CARM1 overexpression increased CDK2 and CDK4 expression. In addition, CARM1 knockdown reduced the number of insulin-induced G2/M phase cells
a noncoding variant in the CARM1-promoter functions as a regulator of gene transcription and homocysteine levels
O-GlcNAcylation of CARM1 at its C-terminus is an important determinant for CARM1 substrate specificity.
PRMT4 has a role in arginine methylation, which negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation
PBMCs from patients with ACS showed higher levels of CARM1 mRNA and protein expression.CARM1 regulated the transcription of IP-10, IL-8, and MCP-1. miR-15a modulated CARM1 expression through targeted binding to CARM1 3'-UTR.
high-glucose-induced CARM1 expression increases RPE cell apoptosis via H3R17 asymmetric dimethylation
CARM1 and PRMT1 are dysregulated in lung cancer; only CARM1 expression was found to be correlated with tumor differentiation and neither CARM1 nor PRMT1 expression was correlated with survival.
C9orf72 acts by promoting the lysosomal degradation of coactivator-associated arginine methyltransferase 1 (CARM1), which in turn regulates autophagy-lysosomal functions and lipid metabolism.
the present study increases our understanding of PRMT1, -4, and -5 biology during the plasticity of skeletal muscle development. Our results provide evidence for a role of PRMT1, via a mitochondrially mediated mechanism, in driving the muscle differentiation program.
Study describes peptide-based transition state mimics that form stable complexes with CARM1 resulting in high-resolution co-crystal structures. The findings provide an exciting approach to understanding protein arginine methyltransferase (PRMT) substrate recognition and the regulation of arginine methylation.
CARM1 promotes EZH2-mediated silencing of EZH2/BAF155 target tumor suppressor genes by methylating BAF155.
These observations demonstrate that oxidative stress destabilizes PRMT4 via GSK-3beta signaling to impede lung epithelial cell migration that may hinder the lung repair and regeneration process.
AMPK deficiency results in nuclear CARM1 decrease mediated in part by SKP2, contributing to autophagy dysfunction in the aged heart.
Study identifies CARM1, which methylates histone H3 at arginine 26 (H3R26), as an upstream regulator of Sox21 expression. These results indicate that heterogeneity in gene expression patterns biases cell fate in the mouse embryo as early as the 4-cell stage.
findings demonstrate that CARM1-dependent histone arginine methylation is a crucial nuclear event in autophagy, and identify a new signalling axis of AMPK-SKP2-CARM1 in the regulation of autophagy induction after nutrient starvation
CARM1 haploinsufficiency impairs transdifferentiation and wound healing in a mouse model.
PRMT4 might be a key regulator of high-glucose-induced insulin secretion from pancreatic beta cells via H3R17 methylation.
Data show that the methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1; PRMT4) methylated Notch intracellular domain (NICD) at five conserved arginine residues.
we identify BAF155 as a substrate for arginine methyltransferase CARM1.
Arginine methylation of Pax7 by Carm1 functions as a molecular switch controlling the epigenetic induction of Myf5 during satellite stem cell asymmetric division and entry into the myogenic program.
CARM1 is a key epigenetic regulator of hematopoiesis that affects multiple lineages at various stages of differentiation.
our study provides evidence for a role of CARM1-mediated arginine methylation in regulation of histone acetylation and transcription.
PRMT4 is necessary for selective control of a specific gene expression program associated with glycogen metabolism.
Substantial quantities of soluble full-length mouse CARM1 were purified from transiently transfected HEK293T cells.
The results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells.
Histone H3 arginine methylation by CARM1 in ES cells allows epigenetic modulation of pluripotency.
CARM1 requires its enzymatic activity for all of its known cellular functions.
a combinatorial role of PRMT4/CARM1 and PRMT5 for proper myogenesis in zebrafish
Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002
histone-arginine methyltransferase CARM1
, protein arginine N-methyltransferase 4
, coactivator-associated arginine methyltransferase 1
, protein arginine methyltransferase