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JIB-04

Inh Cell-permeable 199596-05-9 (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine

1 image

Produktnummer ABIN7233263

Datenblatt (PDF)

Applikation

Inhibition (Inh)

Verwendungszweck

pan-JUMONJI histone demethylase inhibitor

Produktmerkmale

A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model. Suppresses translation initiation and enhances mTOR inhibitor sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.

Reinheit

>98 %

Chemical Name

(E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine

Formel

C17H13ClN4

Permeabilität

Cell-permeable

Löslichkeit

Soluble in DMSO (up to 30 mg/ml).
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Radicicol
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EX-527
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Daminozide
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Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Powder

Lagerung

-20 °C
Hintergrund

Epigenetics,Posttranslational modification,Protein demethylase,Cancer,mTOR,Chromatin

Molekulargewicht

308.76

CAS-Nummer

199596-05-9