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Radicicol

Inh 12772-57-5
Produktnummer ABIN1027739

Kurzübersicht für Radicicol (ABIN1027739)

Applikation

Inhibition (Inh)
  • Verwendungszweck

    Hsp90 inhibitor

    Produktmerkmale

    Hsp90 inhibitor.

    Aufreinigung

    Produced by fermentation

    Reinheit

    97 % by TLC

    Formel

    C18H17CIO6

    Löslichkeit

    Soluble in DMSO
  • Kommentare

    Source: Produced by fermentation.
    Appearance: White to Yellow Solid

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Solid

    Vorsichtsmaßnahmen

    Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

    Handhabung

    Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

    Lagerung

    -20 °C
  • Boufaied, Wioland, Falardeau, Gourdeau: "TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation." in: Anti-cancer drugs, Vol. 21, Issue 5, pp. 543-52, (2010) (PubMed).

  • Hintergrund

    Radicicol inhibits src (IC50=0.27myM) and src-like kinases, leading to hypophosphorylation of retinoblastoma tumor suppressor protein. It causes morphological reversion of ras-transformed cells and leads to selective depletion of Raf kinase. It also displays anti-angiogenic activity, and binds to and inhibits Hsp 90 molecular chaperone. It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1.

    Molekulargewicht

    364.8

    CAS-Nummer

    12772-57-5
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