(1 reference)Kurzübersicht für Radicicol (ABIN1027739)
Applikation
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Verwendungszweck
- Hsp90 inhibitor
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Produktmerkmale
- Hsp90 inhibitor.
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Aufreinigung
- Produced by fermentation
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Reinheit
- 97 % by TLC
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Formel
- C18H17CIO6
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Löslichkeit
- Soluble in DMSO
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
AS-8351Inh 796-42-9 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
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Kommentare
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Source: Produced by fermentation.
Appearance: White to Yellow Solid -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Solid
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Vorsichtsmaßnahmen
- Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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Handhabung
- Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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Lagerung
- -20 °C
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: "TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation." in: Anti-cancer drugs, Vol. 21, Issue 5, pp. 543-52, (2010) (PubMed).
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: "TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation." in: Anti-cancer drugs, Vol. 21, Issue 5, pp. 543-52, (2010) (PubMed).
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Hintergrund
- Radicicol inhibits src (IC50=0.27myM) and src-like kinases, leading to hypophosphorylation of retinoblastoma tumor suppressor protein. It causes morphological reversion of ras-transformed cells and leads to selective depletion of Raf kinase. It also displays anti-angiogenic activity, and binds to and inhibits Hsp 90 molecular chaperone. It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1.
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Molekulargewicht
- 364.8
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CAS-Nummer
- 12772-57-5
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