Influenza Polymerase Basic 2 Protein (PB2) (AA 318-484) (His tag)
Kurzübersicht für Influenza Polymerase Basic 2 Protein (PB2) (AA 318-484) (His tag) (ABIN7937686)
Target
Protein-Typ
Spezies
Quelle
Reinheit
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Proteineigenschaft
- AA 318-484
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Aufreinigungstag / Konjugat
- Dieses Influenza Polymerase Basic 2 Protein ist gelabelt mit His tag.
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Verwendungszweck
- Recombinant Influenza A virus PB2 protein, partial
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Sequenz
- RISSSFSFGG FTFKRTSGSS VKREEEVLTG NLQTLKIRVH EGYEEFTMVG RRATAILRKA TRRLIQLIVS GRDEQSIAEA IIVAMVFSQE DCMIKAVRGD LNFVNRANQR LNPMHQLLRH FQKDAKVLFQ NWGVEPIDNV MGMIGILPDM TPSIEMSMRG VRISKMG
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Kommentare
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C-terminal 6xHis-tagged
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized or Liquid
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Rekonstitution
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50 % of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50 %. Customers could use it as reference.
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Buffer
- If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5 % -50 % glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6 % Trehalose, pH 8.0.
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Handhabung
- Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week.
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Lagerung
- -20 °C,-80 °C
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Informationen zur Lagerung
- The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
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Haltbarkeit
- 6-12 months
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- Influenza Polymerase Basic 2 (PB2)
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Andere Bezeichnung
- PB2
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Substanzklasse
- Influenza Protein
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Hintergrund
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Relevance: Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS
Alternative Name(s): RNA-directed RNA polymerase subunit P3
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Molekulargewicht
- 25.8 kDa
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UniProt
- P03428
Target
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