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IDE ELISA Kits

(Insulin-Degrading Enzyme (IDE))
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].

Häufig verwendete IDE ELISA Kits

Aktuelle Publikationen für unsere IDE ELISA Kits

Jiang, Shuai, Li, Yang, Deng, Li, He, Guo, Li, He: "Protein-Bound Anthocyanin Compounds of Purple Sweet Potato Ameliorate Hyperglycemia by Regulating Hepatic Glucose Metabolism in High-Fat Diet/Streptozotocin-Induced Diabetic Mice." in: Journal of agricultural and food chemistry, Vol. 68, Issue 6, pp. 1596-1608, (2020) (PubMed).

Hafez, Ghareeb, Saleh, Abady, El Demellawy, Hussien, Abdel-Monem: "Neuroprotective effect of ipriflavone against scopolamine-induced memory impairment in rats." in: Psychopharmacology, Vol. 234, Issue 20, pp. 3037-3053, (2018) (PubMed).

Ismail, Ismail, Azmi, Bakar, Yida, Abdullah, Basri et al.: "Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high ..." in: Biomedicine & pharmacotherapy, Vol. 95, pp. 780-788, (2018) (PubMed).

Aguado-Llera, Canelles, Frago, Chowen, Argente, Arilla, Barrios: "The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A." in: Neuroscience, Vol. 374, pp. 104-118, (2018) (PubMed).

Perianes-Cachero, Canelles, Aguado-Llera, Frago, Toledo-Lobo, Carrera, Cacabelos, Chowen, Argente, Arilla-Ferreiro, Barrios: "Reduction in Aβ-induced cell death in the hippocampus of 17β-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone." in: Journal of neurochemistry, Vol. 135, Issue 6, pp. 1257-71, (2016) (PubMed).

Elseweidy, Amin, Atteia, Ali: "Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylation in diabetic rats." in: Biomedicine & pharmacotherapy, Vol. 85, pp. 155-159, (2016) (PubMed).

Johnson, Drugan, Miller, Evans: "38" in: , Vol. 1363, Issue Nucleic acids research, pp. 28-39, (1991)

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