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Huntingtin Proteine

(Huntingtin (HTT))
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008].

8 Treffer

HTT Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Produktnummer ABIN1307290
 
HTT Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant WB, SDS, ELISA
Produktnummer ABIN7577520
 
HTT Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 97 % WB, SDS, Imm, PC
Produktnummer ABIN7399553
 
HTT Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 97 % WB, SDS, Imm, PC
Produktnummer ABIN7409194
 
HTT Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 90 % WB, SDS, Imm, PC
Produktnummer ABIN7399550
 
HTT Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 97 % WB, SDS, Imm, PC
Produktnummer ABIN7399547
 
HTT Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant WB, SDS
Produktnummer ABIN6123558
 
HTT Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant WB, SDS
Produktnummer ABIN6380205
 
  • Typ Protein
    • Protein
  • Anwendung
    • Western Blotting (WB)
    • SDS-PAGE (SDS)
    • Immunogen (Imm)
    • Positive Control (PC)
    • ELISA
    • Affinity Purification (AP)
    • Antibody Array (AA)
  • Reaktivität
    • Human
    • Mouse
    • Rat
  • Abbildungen verfügbar
  • Wirt
    • Escherichia coli (E. coli)
    • Wheat germ
  • Bindungsspezifität
    • AA 782-920
    • AA 803-941
    • AA 81-190
  • Konjugat
    • His tag
    • Unkonjugiert
    • GST tag
    • His tag,GST tag
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Hersteller
    • antibodies-online
    • Abbexa

Aliase für Huntingtin Proteine

huntingtin (HTT) Proteine
huntingtin (htt) Proteine
huntingtin (LOC373520) Proteine
huntingtin (Htt) Proteine
AI256365 Proteine
C430023I11Rik Proteine
CG9995 Proteine
dHtt Proteine
dhtt Proteine
Dmel\\CG9995 Proteine
hd Proteine
HD Proteine
Hd Proteine
Hdh Proteine
Hsap\\HD Proteine
HTT Proteine
Htt Proteine
htt Proteine
huntington Proteine
it15 Proteine
IT15 Proteine
SLC6A4 Proteine
ZHD Proteine
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