HSPG2 Produkte
(Heparan Sulfate Proteoglycan 2 (HSPG2))
Kategorien
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010].
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Ausgewählte HSPG2 Kategorien
HSPG2 Antikörper
High quality antibodies with extensive validation data.
HSPG2 ELISA Kits
Reliable ELISA kits for a wide range of species.
HSPG2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene HSPG2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (12)
Kat. Nr.
ABIN7435115
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN7191019
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
IHC, ELISA
Validierungen
- (2)
Kat. Nr.
ABIN7243733
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene HSPG2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (4)
- (4)
Kat. Nr.
ABIN6730918
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6956480
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6974795
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene HSPG2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1307245
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7396736
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7396733
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren HSPG2 Produkten
: "Characterization of Vascular Patterns Associated with Endothelial Glycocalyx Damage in Early- and Late-Onset Preeclampsia." in: Biomedicines, Vol. 10, Issue 11, (2022) (PubMed).: "Expression and Circulating Levels of Perlecan in Breast Cancer - Implications for Oestrogen Dependent Stromal Remodeling." in: Journal of mammary gland biology and neoplasia, Vol. 25, Issue 1, pp. 69-77, (2020) (PubMed).
: "Dynamic Assembly of Human Salivary Stem/Progenitor Microstructures Requires Coordinated α1β1 Integrin-Mediated Motility." in: Frontiers in cell and developmental biology, Vol. 7, pp. 224, (2019) (PubMed).
: "Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 17, Issue 2, pp. 451-461, (2016) (PubMed).
: "Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme." in: European journal of pharmacology, Vol. 728, pp. 151-60, (2014) (PubMed).
: "Proteomics of Follicular Fluid from Women with Polycystic Ovary Syndrome Suggests Molecular Defects in Follicular Development." in: The Journal of clinical endocrinology and metabolism, pp. jc20142086, (2014) (PubMed).
Synonyme und alternative Namen zu HSPG2
heparan sulfate proteoglycan 2 (HSPG2), heparan sulfate proteoglycan 2 (hspg2), perlecan (heparan sulfate proteoglycan 2) (Hspg2), heparan sulfate proteoglycan 2 (Hspg2), AI852380, HSPG, HSPG2, Pcn, per, Per, PLC, Plc, PRCAN, SJA, SJS, SJS1Bezeichner auf Proteinebene für HSPG2
- basement membrane-specific heparan sulfate proteoglycan core protein
- endorepellin (domain V region)
- perlecan proteoglycan
- heparan sulfate proteoglycan 2
- perlecan
- basement membrane-specific heparan sulfate proteoglycan core protein-like
- HSPG
- perlecan (heparan sulfate proteoglycan 2)
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