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identified two different TBX3 alleles causing non-dun color. non-dun2 is a recently derived allele, whereas the Dun and non-dun1 TBX3 alleles are found in ancient horse DNA, demonstrating that this polymorphism predates horse domestication
TBX3 is not only required for development of posterior forelimb bones (ulna and digits 4 and 5), but also for a subset of posterior muscles (lateral triceps and brachialis) and their bone eminence attachment sites.
High TBX3 expression is associated with invasive breast cancer.
genetic variation of Tbx3 is associated with left ventricular mass in a healthy Japanese population [meta-analysis]
Study demonstrates that miR-206 directly targets Tbx3, that miR-206 and Tbx3 mRNA are inversely correlated in human breast cancer and that Tbx3 repression is necessary to elicit a significant functional effect of miR-206 in breast cancer cells.
The c.1423C>T (p.Q475*) nonsense mutation in exon 6 of the TBX3 gene associated with ulnar-mammary syndrome.
Tbx3 was found to be overexpressed in 46 of 98 human gastric cancer samples
These include a patient with hypoplastic phalanges and absent hallux bilaterally with de novo deletion of 11.9 Mb on 7p21.1-22.1 spanning 63 genes including RAC1, another patient with severe Holt-Oram syndrome and a large de novo deletion 2.2 Mb on 12q24.13-24.21 spanning 20 genes including TBX3 and TBX5, and a third patient with acheiropodia who had a nullizygous deletion of 102 kb on 7q36.3 spanning LMBR1
this new molecular-grade based on the combination of TBX2 and TBX3 methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer.
Paracrine WNT signaling is stimulated by estrogen and progesterone, while autocrine WNT signaling is induced by the embryonic T-box transcription factor TBX3
Overexpression of Tbx3 is associated with pancreatic carcinoma.
Data show that the down-regulation of T-box transcription factor TBX2 by transforming growth factor beta I (TGF-beta1) is mediated by T-box transcription factor TBX3.
Polymorphisms in several genes involved in the Wnt signaling pathway were associated with hepatic fibrosis or inflammation risk in HCV-infected males.
TBX3 gene variants may contribute to indirect inguinal hernia as a rare risk factor by reducing TBX3 levels
An enhancement in TBX3 protein expression both in glomerular and tubular regions.
The pleiotropic effects of TBX3 mutations in humans and mice likely result from disrupting at least two molecular functions of this protein: transcriptional regulation and pre-mRNA splicing.
TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion.
TBX3 plays a pivotal role in mediating the antiproliferative and promigratory role of TGF-beta1 in breast epithelial cells and skin keratinocytes.
TBX3 exon 2 mutation is rare in most human tumors
Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion.
TBX3 gene polymorphism is associated in the development of colorectal cancers.
Tbx3 is required for abdominal skin expansion in pregnant mice.
Tbx2 and Tbx3 function downstream of Shh to maintain pro-proliferative mesenchymal Wnt signaling.
Tbx3 functions upstream of Hes1 to regulate proliferation and differentiation of basal and suprabasal cells during epidermal development.
T-box3 interacts with Kif7 and is required for normal stoichiometry and function of a Kif7/Sufu complex that regulates Gli3 stability and processing.
Low TBX3 levels are associated with reduced pluripotency for embryonic stem cells, resembling the more mature epiblast.
miR-93 controls Tbx3 expression, thereby limiting self-renewal in early adipocyte precursors.
In-depth transcriptome analysis of this mESC state reveals Dppa3 as a direct downstream target of Tbx3.We show that Tbx3, a downstream target of Wnt signaling, fine tunes these divergent roles of Wnt signaling in mESCs
Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/beta-catenin signaling
Tbx3 can activate Zscan4(+)/2C state by negative regulation of DNA methylation at repeated sequences, linking to telomere maintenance and self-renewal of ES cells.
Tbx3 is important for the generation of hormone-sensing cells.
Taken together, we define further facets of TBX3 actions and map TBX3 as an upstream regulator of the mesendoderm transcriptional program during gastrulation.
The Tbx3 locus forms a CTCF-independent autonomous regulatory domain with multiple combinatorial regulatory elements that control the precise pattern of Tbx3 in the cardiac conduction system.
Tbx3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2.
results not only reveal the essential roles of Tbx3 and Tbx3+2a in pluripotency maintaining, but also point out the different mechanistic modes between these two isoforms
The effects of Tbx20 are epistatic to Tbx3 in the heart, but Tbx3 is epistatic to Tbx20 with respect to developmental delay.
Data suggest that the possibility that mechanisms in addition to TBX3 haploinsufficiency may cause Ulnar-mammary syndrome (UMS) or other malformations merits investigation in the human UMS population.
Jmjd3 sequentially associates with two T-box factors, Tbx3 and Eomes to drive stem cell differentiation towards the definitive endoderm lineage.
formation of the neurohypophysis requires Tbx3 and Tbx2 to sequester the SRY box-containing transcription factor Sox2 away from a Shh forebrain enhancer (SBE2)
Data indicate the role and regulation of T-box transcription factor TBX3 in limb development.
Results suggested that Tbx3 and Nr5alpha2 may have vital roles in pluripotent stem cells.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms\; however, the full length nature of one variant has not been determined.
, transcription factor Tbx3
, T-box 3 protein
, T-box 3 (ulnar mammary syndrome)
, T-box transcription factor TBX3-like
, t-box transcription factor TBX3-like
, T-box protein 3
, T-box transcription factor TBX3
, bladder cancer related protein XHL
, T-Box protein 3