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identified two different TBX3 alleles causing non-dun color. non-dun2 is a recently derived allele, whereas the Dun and non-dun1 TBX3 alleles are found in ancient horse DNA, demonstrating that this polymorphism predates horse domestication
TBX3 is not only required for development of posterior forelimb bones (ulna and digits 4 and 5), but also for a subset of posterior muscles (lateral triceps and brachialis) and their bone eminence attachment sites.
High TBX3 expression is associated with invasive breast cancer.
genetic variation of Tbx3 is associated with left ventricular mass in a healthy Japanese population [meta-analysis]
Study demonstrates that miR (zeige MLXIP Proteine)-206 directly targets Tbx3, that miR (zeige MLXIP Proteine)-206 and Tbx3 mRNA are inversely correlated in human breast cancer and that Tbx3 repression is necessary to elicit a significant functional effect of miR (zeige MLXIP Proteine)-206 in breast cancer cells.
The c.1423C>T (p.Q475*) nonsense mutation in exon 6 of the TBX3 gene associated with ulnar-mammary syndrome.
Tbx3 was found to be overexpressed in 46 of 98 human gastric cancer samples
These include a patient with hypoplastic phalanges and absent hallux bilaterally with de novo deletion of 11.9 Mb on 7p21.1-22.1 spanning 63 genes including RAC1, another patient with severe Holt-Oram syndrome and a large de novo deletion 2.2 Mb on 12q24.13-24.21 spanning 20 genes including TBX3 and TBX5 (zeige TBX5 Proteine), and a third patient with acheiropodia who had a nullizygous deletion of 102 kb on 7q36.3 spanning LMBR1 (zeige LMBR1 Proteine)
this new molecular-grade based on the combination of TBX2 (zeige TBX2 Proteine) and TBX3 methylation is an excellent marker for predicting progression to muscle-invasive bladder cancer in patients with primary pTaG1/2 bladder cancer.
Paracrine WNT (zeige WNT2 Proteine) signaling is stimulated by estrogen and progesterone, while autocrine WNT (zeige WNT2 Proteine) signaling is induced by the embryonic T-box transcription factor TBX3
Overexpression of Tbx3 is associated with pancreatic carcinoma.
Tbx3 is required for abdominal skin expansion in pregnant mice.
Tbx2 (zeige TBX2 Proteine) and Tbx3 function downstream of Shh (zeige SHH Proteine) to maintain pro-proliferative mesenchymal Wnt (zeige WNT2 Proteine) signaling.
Tbx3 functions upstream of Hes1 (zeige HES1 Proteine) to regulate proliferation and differentiation of basal and suprabasal cells during epidermal development.
T-box3 interacts with Kif7 and is required for normal stoichiometry and function of a Kif7/Sufu (zeige SUFUH Proteine) complex that regulates Gli3 (zeige GLI3 Proteine) stability and processing.
Low TBX3 levels are associated with reduced pluripotency for embryonic stem cells, resembling the more mature epiblast.
miR (zeige MLXIP Proteine)-93 controls Tbx3 expression, thereby limiting self-renewal in early adipocyte precursors.
In-depth transcriptome analysis of this mESC state reveals Dppa3 (zeige DPPA3 Proteine) as a direct downstream target of Tbx3.We show that Tbx3, a downstream target of Wnt (zeige WNT2 Proteine) signaling, fine tunes these divergent roles of Wnt (zeige WNT2 Proteine) signaling in mESCs
Hoxc8 (zeige HOXC8 Proteine) initiates an ectopic mammary program by regulating Fgf10 (zeige FGF10 Proteine) and Tbx3 expression and Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling
Tbx3 can activate Zscan4 (zeige ZSCAN4 Proteine)(+)/2C state by negative regulation of DNA methylation (zeige HELLS Proteine) at repeated sequences, linking to telomere maintenance and self-renewal of ES cells.
Results suggested that Tbx3 and Nr5alpha2 may have vital roles in pluripotent stem cells.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms\; however, the full length nature of one variant has not been determined.
, transcription factor Tbx3
, T-box 3 protein
, T-box 3 (ulnar mammary syndrome)
, T-box transcription factor TBX3-like
, t-box transcription factor TBX3-like
, T-box protein 3
, T-box transcription factor TBX3
, bladder cancer related protein XHL
, T-Box protein 3