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Human SHBG Protein expressed in Human - ABIN935784
Hauptmann, Metzger, Schnitzbauer, Cuilleron, Mappus, Luppa: Syntheses and ligand-binding studies of 1 alpha- and 17 alpha-aminoalkyl dihydrotestosterone derivatives to human sex hormone-binding globulin. in Steroids 2003
Study comparing gastric cancer (GC) patients and normal subjects identified that plasma SHBG levels could be a potential early diagnostic biomarker for gastric cancer. A western blot assay showed that SHBG was consistently overexpressed in the patient group. ELISA measurement of SHBG blood plasma levels confirmed that the patient group had significantly higher SHBG levels than the control group.
REVIEW: estrogen receptors and sex hormone binding globulin in neuronal cells and tissue
Men with higher SHBG levels had lower bone mineral density at the lumbar spine and hip and had a 1.8-fold increased risk of nonvertebral fractures. Study results conclude that SHBG is a novel biomarker associated with fracture in men with chronic kidney disease receiving dialysis.
SHBG is the autosomal gene where variants have been demonstrated to be associated with Testosterone (one of Cardiovascular disease risk factors) at genome-wide significance.
low SHBG is a marker of abdominal obesity and increased serum triglycerides
SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome
SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T.
Low SHBG expression not only participates in the development of local insulin resistance, but may also play an important role in PI3K/AKT pathway-mediated systemic insulin resistance and gestational diabetes.
Fibulin-1 is expressed in breast cancer cell lines, interacts wtih SHBG, and is increased by estradiol
These data, therefore, reflected that SHBG single nucleotide polymorphism rs6259 causes changes in placental SHBG concentration and may play a functional role in the molecular mechanisms of the gestational diabetes mellitus etiology.
This is the first study that provides detailed analyses of SHBG with metabolic syndrome components in male diabetic subjects.
in postmenopausal women, aromatase activity could be an important determinant of skeletal health.
Consumption of high coffee and caffeine is associated with a reduced risk of low SHBG, an established risk marker for T2DM, which might contribute to the protective effects of coffee for type 2 diabetes.
Circulating sex steroids, prolactin, insulin-like growth factor (IGF) I, IGF-binding protein 3, and sex hormone-binding globulin (SHBG) were evaluated using backward elimination separately in women pre- and postmenopausal at blood collection.
Patient-associated features such as body mass index and serum levels of Testosterone and SHBG can improve the predictive capability of consolidate tumor-specific biomarkers in both pre- and postmenopause.
relationship of testosterone, sex hormone-binding globulin (SHBG), and IGF-1 with bone mineral density (BMD) and bone turnover markers (BTMs) in Korean men, is reported.
SHBG increased total androgen and estrogen concentrations via hypothalamic-pituitary feedback regulation and prolonged ligand half-life.
low serum SHBG is associated with insulin resistance in men with nonalcoholic fatty liver disease.
no association was seen between the stuttering and digit ratio, progesterone, or SHBG
there is limited clinical utility of serum Estradiol, Testosterone, and SHBG measures for the evaluation of osteoporosis risk in elderly men.
A wave of apoptosis during the pre-pubertal period is required for normal spermatogenesis to develop, and our data indicate that this apoptotic wave may be regulated by ABP and/or androgens.
USF transcription factors repress SHBG transcription in Sertoli cells through an interaction with FP4 within its proximal promoter
monosaccharide-induced lipogenesis reduced hepatic HNF-4alpha levels, which in turn attenuated SHBG expression.
characterization of the zebrafish SHBG gene and protein through molecular biological, biochemical, and informatics approaches
SHBG controls the flux of sex steroids across fish.
Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes.
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene.
sex steroid-binding protein
, testis-specific androgen-binding protein
, testosterone-binding beta-globulin
, testosterone-estradiol-binding globulin
, testosterone-estrogen-binding globulin
, sex hormone-binding globulin
, Sex hormone binding globulin or androgen-binding protein (other gene product from ABP gene)
, androgen binding protein 1 (296 AA)
, sex hormone binding globulin
, sex hormone-binding globulin protein
, LOW QUALITY PROTEIN: sex hormone-binding globulin
, sex hormone binding globulin L homeolog