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Human SHBG Protein expressed in Human - ABIN935784
Hauptmann, Metzger, Schnitzbauer, Cuilleron, Mappus, Luppa: Syntheses and ligand-binding studies of 1 alpha- and 17 alpha-aminoalkyl dihydrotestosterone derivatives to human sex hormone-binding globulin. in Steroids 2003
low serum SHBG is associated with insulin (zeige INS Proteine) resistance in men with nonalcoholic fatty liver disease.
no association was seen between the stuttering and digit ratio, progesterone, or SHBG
there is limited clinical utility of serum Estradiol, Testosterone, and SHBG measures for the evaluation of osteoporosis risk in elderly men.
endogenous steroid hormone, sex hormone-binding globulin, and precursor steroids are associated with hemostatic factors in postmenopausal women
cross-sectional associations between individual bioavailable sex hormones and SHBG with radiographically assessed kyphosis, were examined.
Temporal change in serum SHBG, but not Testosterone, Estradiol, or other hormonal variables, was significantly associated with any, nonvertebral or hip fracture incidence in univariable analyses.
In vitro androgen bioactivity reflects the inhibitory effects of SHBG.
In men with hepatic steatosis, we found that elevated serum ALT levels were associated with lower serum SHBG levels.
In the total population adjusting for race/ethnicity, there was no association between SHBG and fracture in women. The interaction between race/ethnicity and SHBG was also not statistically significant.
Depression and anxiety in subfertile males are associated with lower secretion of SHBG.
A wave of apoptosis during the pre-pubertal period is required for normal spermatogenesis to develop, and our data indicate that this apoptotic wave may be regulated by ABP and/or androgens.
USF transcription factors repress SHBG transcription in Sertoli cells through an interaction with FP4 within its proximal promoter
monosaccharide-induced lipogenesis reduced hepatic HNF-4alpha (zeige HNF4A Proteine) levels, which in turn attenuated SHBG expression.
characterization of the zebrafish SHBG gene and protein through molecular biological, biochemical, and informatics approaches
SHBG controls the flux of sex steroids across fish.
Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes.
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene.
sex steroid-binding protein
, testis-specific androgen-binding protein
, testosterone-binding beta-globulin
, testosterone-estradiol-binding globulin
, testosterone-estrogen-binding globulin
, sex hormone-binding globulin
, Sex hormone binding globulin or androgen-binding protein (other gene product from ABP gene)
, androgen binding protein 1 (296 AA)
, sex hormone binding globulin
, sex hormone-binding globulin protein
, LOW QUALITY PROTEIN: sex hormone-binding globulin
, sex hormone binding globulin L homeolog