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Human GATA3 Protein expressed in Wheat germ - ABIN1354834
Kuwahara, Yamashita, Shinoda, Tofukuji, Onodera, Shinnakasu, Motohashi, Hosokawa, Tumes, Iwamura, Lefebvre, Nakayama: The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-? and suppresses T(H)2 differentiation. in Nature immunology 2012
Show all 4 Pubmed References
Human GATA3 Protein expressed in HEK-293 Cells - ABIN2721729
Kao, Stankovic: Transactivation of human osteoprotegerin promoter by GATA-3. in Scientific reports 2015
GATA3 mutations, recently observed in breast cancer, encode active transcription factors.
KMT1A (zeige SUV39H1 Proteine) positively regulated the self-renewal and tumorigenicity of human Bladder cancer stem cells via KMT1A (zeige SUV39H1 Proteine)-GATA3-STAT3 (zeige STAT3 Proteine) circuit, in which KMT1A (zeige SUV39H1 Proteine) could be a promising target for bladder cancer therapy.
Defective sirtuin-1 (zeige SIRT1 Proteine) was found to increase IL-4 (zeige IL4 Proteine) expression through acetylation of GATA-3 in patients with severe asthma compared with healthy controls.
GATA3 activation was diminished upon cultivation of T cells with RNase 7 (zeige RNASE7 Proteine).
overexpression of GATA3 and FOXA1 (zeige FOXA1 Proteine) cooperate with PPAR (zeige PPARA Proteine) activation to drive transdifferentiation of a basal bladder cancer cells to a luminial phenotype.
The data have demonstrated that GATA3 is by far the most reliable breast-specific immunomarker in both surgical and cytological specimens
GATA3 interacts with and is acetylated by the acetyltransferase CBP (zeige CREBBP Proteine). The major acetylated site of GATA3 in lung adenocarcinoma cells is lysine 119.
GATA3 may be useful as a part of a panel of immunohistochemical markers in narrowing the differential diagnosis between pheochromocytoma and adrenal cortical carcinoma
Authors demonstrated that ER(alpha (zeige ESR1 Proteine)), GATA3 and FOXA1 (zeige FOXA1 Proteine) form a transcriptional complex with Ell3 (zeige ELL3 Proteine) to regulate IL-20 (zeige IL20 Proteine) expression in ER(+) breast cancer cells. FOXA1 (zeige FOXA1 Proteine) represses IL-20 (zeige IL20 Proteine) expression, whereas GATA3 and ER(alpha (zeige ESR1 Proteine)) activate it.
We have identified ZPO2 as a negative regulator of GATA3, thus providing an alternative mechanism that results in a reduction in or perhaps even loss of GATA3 during breast cancer development.
Transcription factor GATA3 is responsible for the ER stress-induced TRIP-Br2 (zeige SERTAD2 Proteine) expression in visceral fat.
GATA-3 participates in the healing of bone fractures via regulating bcl-xL (zeige BCL2L1 Proteine) gene expression, owing to its association with Runx2 (zeige RUNX2 Proteine).
Gata3 deficiency promotes B cell differentiation and proliferation, and cooperates with p18 (zeige CDKN2C Proteine) loss to induce B cell lymphomas
Findings suggest that VEGF (zeige VEGFA Proteine) gene expression can be suppressed by TNFSF15 (zeige TNFSF15 Proteine)-stimulated activation of the JNK (zeige MAPK8 Proteine)-GATA3 signaling pathway which gives rise to up-regulation of miR (zeige MLXIP Proteine)-29b.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3, SATB1 (zeige SATB1 Proteine), and IRF4 (zeige IRF4 Proteine).
the model of mutually antagonistic differentiation programs driven by mutually exclusively expressed T-bet or GATA-3 does not completely explain natural CD4 (zeige CD4 Proteine) T cell priming outcomes
MIF (zeige MIF Proteine)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 expression and IL-13 (zeige IL13 Proteine) production in the mesenteric lymph nodes
study demonstrates a role for HOX5 (zeige HOXB5 Proteine) proteins in controlling lung inflammation during a model of allergic asthma. The increased inflammation in the Hox5 (zeige HOXB5 Proteine)-deficient mice was mediated by increased Th2 cell development, which was associated with regulation of Gata3 expression
Treg cell accumulation in intestinal tumours from APC (zeige APC Proteine)(min/+) mice was exclusively due to the increase in KLRG1 (zeige KLRG1 Proteine)(+) GATA3(+) Treg cells.
gata3 acts as a specific injury-induced proregenerative factor that is essential for the regenerative capacity in vertebrates
GATA2 (zeige GATA2 Proteine) and/or GATA3 are involved in the regulation of trophoblast-specific gene transcription in bovine trophoblast CT-1 (zeige SLC6A8 Proteine) cells
study identified rainbow trout and Atlantic salmon IL-4 (zeige IL4 Proteine)/13A, a homologue of mammalian Th2 cytokine genes IL-4 (zeige IL4 Proteine) and IL-13 (zeige IL13 Proteine); salmonid IL-4 (zeige IL4 Proteine)/13A and GATA-3 were found highly expressed in thymus, gill, and skin
T cells expressed low levels of GATA-3, which decreased with age.
The myocardial immune dysfunction induced by the change in expression levels of the transcription factors GATA-3 and T-bet may be involved in the process of post-resuscitation myocardial injury in a porcine model of cardiac arrest.
Pig GATA-3 cDNA was obtained by reverse transcription polymerase chain reaction (RT-PCR), using in silico cloning strategy based on pig dbEST (zeige BEST1 Proteine).
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
GATA-binding factor 3
, trans-acting T-cell-specific transcription factor GATA-3
, GATA-binding protein 3
, transcription factor GATA-3
, GATA binding factor-3
, transcription factor xGATA-3
, transcription factor NF-E1c
, GATA binding protein 3
, putative amidase
, trans-acting T-cell-specific transcription factor GATA-3-like