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Human GATA3 Protein expressed in Wheat germ - ABIN1354834
Kuwahara, Yamashita, Shinoda, Tofukuji, Onodera, Shinnakasu, Motohashi, Hosokawa, Tumes, Iwamura, Lefebvre, Nakayama: The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-? and suppresses T(H)2 differentiation. in Nature immunology 2012
Show all 4 Pubmed References
Human GATA3 Protein expressed in HEK-293 Cells - ABIN2721729
Kao, Stankovic: Transactivation of human osteoprotegerin promoter by GATA-3. in Scientific reports 2015
results demonstrate that GATA3 is involved in the regulation of filaggrin and filaggrin-2 expression during inflammatory conditions in the skin.
demonstrated a correlation between GATA3 expression and only ER+ and suggest that a higher GATA3 expression is a good prognostic factor for OS for ER+ BC patients
We show that MSK1 downregulation impairs the differentiation of breast cancer cells, increasing their bone homing and growth capacities. MSK1 controls the expression of genes required for luminal cell differentiation, including the GATA3 and FOXA1 transcription factors, by modulating their promoter chromatin status.
GATA3 and TP53INP1 were identified as targets of miR155. Exosomal miR155 inhibited these targets by directly targeting their 3' untranslated regions. Knockdown of miR1555p was observed to reverse the EMT and chemoresistant phenotypes of gastric cancer cells, potentially via GATA3 and TP53INP1 upregulation.
This review summarizes the various contributions of Gata3 to haematopoiesis with a particular focus on the emergence of the first haematopoietic stem cells in the embryo-a process that appears to be influenced by Gata3 at various levels, thus highlighting the complex nature of Gata3 action.
findings provide evidence for a new role for GATA3 in ovarian HGSC stemness, and demonstrate that GATA3 may serve as a biomarker for precision epigenetic therapy in the future
Retrospective immunohistochemical analysis of GATA3 expression in 164 breast cancer metastases showed a striking difference between mammaglobin and GATA3 expression (51.2% vs 94% positivity). These findings highlight GATA3 as a more reliable and sensitive diagnostic marker for breast cancer metastases and possibly metastatic tumors of unknown origin than mammaglobin.
GATA-3 expression was the highest in luminal breast carcinomas, and showed higher sensitivity than GCDFP-15 and MGB. However, in the poorly differentiated IBC, its utility was still limited. One should be aware of the possible GATA-3 expression in lung carcinomas.
GATA3 rs3824662 is not associated with susceptibility to systemic lupus erythematosus (SLE) either in adult or in pediatric patients; however, in pediatric SLE patients, the heterozygous AC genotype could be considered a risk factor for lupus nephritis (LN). At the same time, the AC and AA genotypes could be considered as predictors for LN and active renal disease.
The data indicate that expression of CRTh2 is regulated through the competitive action of GATA3 and NFAT1.
the present study postulates that the genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the Bangladeshi population.
one allele of the GATA3 second zinc finger leads to loss of binding and decreased expression at a subset of genes, including Progesterone Receptor
Study established an important role of p38gamma MAPK in epithelial-mesenchymal transition (EMT) and identified a novel signaling pathway for p38gamma MAPK-mediated tumor promotion. p38gamma MAPK regulated miR-200b through inhibiting GATA3 by inducing its ubiquitination, leading proteasome-dependent degradation.
Treg cells from asthmatic patients expressed more FOXP3 as well as GATA3; the expression level of GATA3 negatively correlated with FEV1%pred. Increased expressions of USP21 and PIM2 in Treg cells from asthmatic patients were found.
GATA 3 is more sensitive marker than mammaglobin and GCDFP-15 for diagnosing metastatic breast carcinoma in cytological cell block materials
This study demonstrates consistent GATA-3 staining in walthard nests, rare staining in adenomatoid tumors, and is otherwise rarely positive in normal urologic and gynecologic mesothelia. Furthermore, GATA-3 is uniformly positive in epididymi and negative in efferent ductules which may reflect the embryological evolvement of these tissues.
GATA3 staining to differentiate primary cutaneous apocrine cribriform carcinoma from skin breast cancer metastasis has a high negative predictive value
GATA3 mutations, recently observed in breast cancer, encode active transcription factors.
KMT1A positively regulated the self-renewal and tumorigenicity of human Bladder cancer stem cells via KMT1A-GATA3-STAT3 circuit, in which KMT1A could be a promising target for bladder cancer therapy.
Defective sirtuin-1 was found to increase IL-4 expression through acetylation of GATA-3 in patients with severe asthma compared with healthy controls.
OVE has a sufficient regulatory activity to direct Gata3 expression.
BMP and FGF signaling can up-regulate expression of Gata3 in differentiating lens fiber cells through the identified Gata3 enhancer and promoter elements.
our data identify how overexpression of T-bet and Gata3 in T cells alters anti-viral immunity and confers susceptibility to TMEV infection.
Overexpression of sirtuin 6 suppresses allergic airway inflammation through deacetylation of GATA3.
while HDAC6 and Bcl6 are important regulators of T-regulatory cells plasticity, GATA3 determine the fate of plastic T-regulatory cells by controlling whether it will convert in to either Th1-T-regulatory cells or Antigen-Presenting Cell-T-regulatory cells
The enhanced Th1 and Th2 immune response in K + O immunized mice was also supported by the increased expression of Tbx21 and GATA-3 transcription factors in splenocytes. This corroborated with increased BLIMP-1 and Oct-2 protein expression.
Transcription factor GATA3 is responsible for the ER stress-induced TRIP-Br2 expression in visceral fat.
GATA-3 participates in the healing of bone fractures via regulating bcl-xL gene expression, owing to its association with Runx2.
Gata3 deficiency promotes B cell differentiation and proliferation, and cooperates with p18 loss to induce B cell lymphomas
We have identified ZPO2 as a negative regulator of GATA3, thus providing an alternative mechanism that results in a reduction in or perhaps even loss of GATA3 during breast cancer development.
Findings suggest that VEGF gene expression can be suppressed by TNFSF15-stimulated activation of the JNK-GATA3 signaling pathway which gives rise to up-regulation of miR-29b.
RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4.
the model of mutually antagonistic differentiation programs driven by mutually exclusively expressed T-bet or GATA-3 does not completely explain natural CD4 T cell priming outcomes
MIF-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 expression and IL-13 production in the mesenteric lymph nodes
study demonstrates a role for HOX5 proteins in controlling lung inflammation during a model of allergic asthma. The increased inflammation in the Hox5-deficient mice was mediated by increased Th2 cell development, which was associated with regulation of Gata3 expression
Treg cell accumulation in intestinal tumours from APC(min/+) mice was exclusively due to the increase in KLRG1(+) GATA3(+) Treg cells.
GATA3 abundance regulates the recombination propensity at the Tcrb locus.
impairment of trophoblast-specific GATA2/GATA3 function could lead to early pregnancy failure
both Gata2 and Gata3 are redundantly required for differentiation of the serotonergic and glutamatergic neurons of the dorsal raphe
priming of T helper cells by IL-6-deficient antigen-presenting dendritic cells preferentially leads to accumulation of a subset of Follicular helper T cells characterized by high expression of GATA3 and IL-4.
gata3 acts as a specific injury-induced proregenerative factor that is essential for the regenerative capacity in vertebrates
GATA2 and/or GATA3 are involved in the regulation of trophoblast-specific gene transcription in bovine trophoblast CT-1 cells
study identified rainbow trout and Atlantic salmon IL-4/13A, a homologue of mammalian Th2 cytokine genes IL-4 and IL-13; salmonid IL-4/13A and GATA-3 were found highly expressed in thymus, gill, and skin
T cells expressed low levels of GATA-3, which decreased with age.
The myocardial immune dysfunction induced by the change in expression levels of the transcription factors GATA-3 and T-bet may be involved in the process of post-resuscitation myocardial injury in a porcine model of cardiac arrest.
Pig GATA-3 cDNA was obtained by reverse transcription polymerase chain reaction (RT-PCR), using in silico cloning strategy based on pig dbEST.
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
GATA-binding factor 3
, trans-acting T-cell-specific transcription factor GATA-3
, GATA-binding protein 3
, transcription factor GATA-3
, GATA binding factor-3
, transcription factor xGATA-3
, transcription factor NF-E1c
, GATA binding protein 3
, putative amidase
, trans-acting T-cell-specific transcription factor GATA-3-like