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Human Polyclonal FAM3B Primary Antibody für IHC, IHC (p) - ABIN4310371
Uhlén, Oksvold, Älgenäs, Hamsten, Fagerberg, Klevebring, Lundberg, Odeberg, Pontén, Kondo, Sivertsson: Antibody-based protein profiling of the human chromosome 21. in Molecular & cellular proteomics : MCP 2012
FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice.
Data suggest that serum PANDER levels are significantly elevated in patients with long-standing type 2 diabetes as compared to patients with recently diagnosed type 2 diabetes and control subjects; serum PANDER levels vary according to degree of insulin (zeige INS Antikörper) resistance.
Circulating level of pancreatic-derived factor (PANDER) in relation to the accumulation in metabolic syndrome suggested that persons with elevated levels of PANDER were associated with an increased risk of metabolic syndrome.
in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP (zeige MLXIPL Antikörper).
beta-cell-secreted PANDER regulated the hepatic insulin (zeige INS Antikörper) and lipogenenic signaling and impact overall glycemia.
our studies demonstrated that silencing FAM3B promoted p53 (zeige TP53 Antikörper) phosphorylation and induced p53 (zeige TP53 Antikörper) accumulation by decreasing Mdm2 (zeige MDM2 Antikörper) expression, which resulted in apoptotic cell death.
These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug.
Helices B and C and the second disulfide bond of PANDER are essential for PANDER-induced beta-cell death.
PANDER is secreted from 2 types of pancreatic cells, glucose stimulates its secretion in beta cell and primary islets but not in alpha-cells, it is likely cosecreted with insulin (zeige INS Antikörper), and structure and conformation is vital for PANDER secretion.
these findings indicate that intestinal L cells are responsive to PANDER, and elevated PANDER levels impair GLP-1 (zeige GCG Antikörper) production in vitro and in vivo.
PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway.
F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 (zeige DGAT1 Antikörper) expression
X-ray crystal structure of the mouse FAM3B protein.
these results demonstrated that the JNK (zeige MAPK8 Antikörper)-mediated signaling mechanism of palmitic acid -induced beta-cell apoptosis involves up-regulated expression of PANDER and activation of caspase-3 (zeige CASP3 Antikörper).
Data suggest a new link between the endocrine and immune systems and provide useful information for further investigating the physiological functions of PANDER and its involvement in inflammation-related pancreatic disorders.
Palmitic acid induces the expression of PANDER and the apoptosis of beta-TC3 cells while glucagon-like peptide-1 (zeige GCG Antikörper) counteracts the above effects through an activation of Akt (zeige AKT1 Antikörper) signaling.
PANDER promotes lipogenesis and compromises insulin (zeige INS Antikörper) signaling in the liver by increasing FOXO1 (zeige FOXO1 Antikörper) activity.
Findings further indicate PANDER impacts glycemic levels and may represent a potential but complicated therapeutic target.
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Present in insulin secretory granules and likely cosecreted with insulin.
family with sequence similarity 3, member B
, cytokine-like protein 2-21
, pancreatic derived factor
, pancreatic-derived factor
, protein FAM3B