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Study conclude that CART is a regulator of glucose homeostasis and could play an important role in the pathophysiology of type 2 diabetes. Based on the ability of CART to increase insulin (zeige INS Antikörper) secretion and reduce glucagon (zeige GCG Antikörper) secretion, CART-based agents could be a therapeutic modality in type 2 diabetes.
In sam (zeige LEP Antikörper)ples from patients undergoing IVF, there is a significant positi (zeige MAPK1 Antikörper)ve correlation between pa (zeige CYP19A1 Antikörper)tient BMI, CART mRNA expression in granulosa cells, and CART peptide levels in follicular fluid.
Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (CART) in KP-immunoreactive (IR) and perikarya and in KP-IR and NKB (zeige TAC3 Antikörper)-IR axon varicosities.
In schizophrenia patients on clozapine monotherapy, CART levels did not correlate with age, weight, BMI, abdominal, waist and hip circumferences, WHR, blood pressure, clozapine dose or treatment duration, body composition, or markers of insulin (zeige INS Antikörper) resistance
Family-based association study failed to observe a statistically significant association for any of the genotyped SNPs in the CARTPT gene and attention-deficit hyperactivity disorder.
Ischemia insult triggered by oxygen-glucose deprivation (OGD (zeige FGFR1 Antikörper)) enhances NRSF (zeige REST Antikörper) mRNA levels and then NRSF (zeige REST Antikörper) antagonizes the CREB (zeige CREB1 Antikörper) signaling on CART activation, leading to augmented cell death.
It was shown that cocaine- and amphetamine-regulated transcript protein (CART) increases the transcriptional activity of estrogen receptor alpha (zeige ESR1 Antikörper) and that CART stimulates an autocrine/paracrine loop within tumor cells to amplify the CART signal.
Study showed that the perikarya and central terminals of vagal afferents are invariably enriched in CART and devoid of melanin-concentrating hormone (zeige PMCH Antikörper) and that neuropeptidergic profile of the CART-positive vagal afferents is remarkably stable across the energy balance spectrum.
Leptin (zeige LEP Antikörper) induced CART negatively affects intracellular cAMP levels, MAPK (zeige MAPK1 Antikörper) signaling, and aromatase (zeige CYP19A1 Antikörper) mRNA expression, which leads to lower estradiol synthesis in granulosa cells and altered ovarian folliculogenesis.
The lack of brain Ucn (zeige UCN Antikörper) 1 immunoreactivity at birth and the gradual postnatal increase in Ucn (zeige UCN Antikörper) 1 in the perioculomotor area suggests that this peptide plays a greater behavioral role in adulthood than during the early postnatal development of an organism.
Ucn1 (zeige UCN Antikörper), CART and nesfatin-1/NUCB2 (zeige NUCB2 Antikörper) are specifically involved in the response of Edinger-Westphal nucleus neurons to acute stress in the mouse
leptin (zeige LEP Antikörper) modulates arcuate cocaine- and amphetamine-regulated transcript expression in obese A(y)/a mice
studies indicate that the CART proximal promoter lies within the 5'-most 641 bp and that in GH3 cells the CART gene is regulated via a cyclic AMP (zeige TMPRSS5 Antikörper)-dependent pathway
Processing of pro-CART revealed that PC2 (zeige CBX4 Antikörper) is more potent than PC1/3 (zeige PCSK1 Antikörper) in generating bioactive CART I; bioactive CART II is solely generated by PC2 (zeige CBX4 Antikörper); and PC1/3 (zeige PCSK1 Antikörper) is predominantly active in liberating the two intermediate CART fragments, 33-102 and 10-89.
Results provide evidence that the calcium response element of the cocaine- and amphetamine-regulated transcript (CART) proximal promoter is involved in cyclic AMP (zeige TMPRSS5 Antikörper)/protein kinase A/CREB (zeige CREB1 Antikörper) regulation in cells having a neuronal phenotype.
CART ('cocaine amphetamine regulated transcript'), a neuropeptide whose expression is controlled by leptin (zeige LEP Antikörper) and nearly abolished in ob/ob mice, inhibits bone resorption by modulating Rankl (zeige TNFSF11 Antikörper) expression
cocaine and amphetamine regulated transcript
Potent inhibitory effects of CART on multiple components of the follitropin (zeige FSHB Antikörper) signaling pathway linked to follicular development.
The intracellular mechanism of action of CART in regulation of FSH (zeige BRD2 Antikörper)-induced MAPK (zeige MAPK1 Antikörper) signaling.
This study showed that CART present in the pelvic plexus (PP) may influence the activity of pelvic ganglionic neurons/SIF cells, that the PP should be considered as a potential source of CART-like supply to pelvic viscera, and that functional interactions between CART and substance P (zeige TAC1 Antikörper) or PACAP (zeige ADCYAP1 Antikörper) are possible at the periphery.
CgA (zeige CHGA Antikörper) and CgB (zeige CHGB Antikörper) have been used as general NEN biomarkers for many years, while CART has only recently been identified
The present study reports for the first time on the co-localisation of CART and VIP (zeige Vip Antikörper) in myenteric neurons of the porcine transverse colon.
Distribution and chemical coding pattern of the cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in the preoptic area of the pig
This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in this gene are associated with susceptibility to obesity.
cocaine and amphetamine regulated transcript
, cocaine- and amphetamine-regulated transcript protein
, cocaine and amphetamine responsive transcript