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Cow (Bovine) Polyclonal GOT1 Primary Antibody für IHC, WB - ABIN2783280
Inoue, Matsumoto, Miyoshi, Kobayashi: Elevated liver enzymes in women with a family history of diabetes. in Diabetes research and clinical practice 2008
Show all 3 Pubmed References
Human Polyclonal GOT1 Primary Antibody für ELISA, WB - ABIN548054
Teichberg: From the liver to the brain across the blood-brain barrier. in Proceedings of the National Academy of Sciences of the United States of America 2007
findings demonstrate that miR-9 regulates ferroptosis by targeting GOT1 in melanoma cells, illustrating the important role of miRNA in ferroptosis.
we assessed the stability of pyridoxal 5'-phosphate (PLP) bound to hGOT1 for the three variant and wildtype (WT) proteins. Conformational transition was associated with the rearrangement of the P15-R32 small domain loop providing substrate access to the R387/R293 binding motif. The amino acid substitutions at positions 266, 267, and 300 reduced the structural correlation between PLP and the protein active site
Study suggests an important role of GOT1 to coordinate the glycolytic and the oxidative phosphorylation pathways in KRAS mutated cancer cells. High levels of GOT1 were further linked to poor survival as analysed by the GEPIA web tool, in thyroid and breast carcinoma and in lung adenocarcinoma.
high transaminase elevations do not predict severe complications or reflect remnant ischemic area.
Missense variant (p.Gln208Glu, rs374966349) in glutamate oxaloacetate transaminase 1 (GOT1) was found, as a putative causal variant predisposing to Familial Macro-aspartate aminotransferase .
HIF-2a regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway and GOT1 expression in human pancreatic ductal adenocarcinoma.
ALT is a more suitable index than AST for developing a regression model.
High AST1 expression is associated with high mortality in hemodialysis patients.
GOT1 plays an important role in energy metabolism and ROS balance in chronic acidosis stress in pancreatic tumor cells.
Early abnormal liver enzyme levels of aspartate aminotransferase and alanine aminotransferase may increase the prevalence of human cytomegalovirus antigenemia after hematopoietic stem cell transplantation.
Elevated preoperative aspartate aminotransferase-to-platelet ratio index may be independently associated with poor overall survival and disease-free survival in hepatocellular carcinoma patients following curative resection
Elevated levels of ALT are Associated with Cardiovascular disease.
Elevated aspartate aminotransferase level was associated with hepatocellular carcinoma.
The serum hepcidin, ferritin, alanine transaminase, aspartate transaminase, gamma-glutamyltransferase and bilirubin were examined in two independent Chinese cohorts consisted of 3455 individuals.
Data suggest that, in context of abnormal hepatic lipid accumulation in nonalcoholic fatty liver disease, circulating GOT1 rises due to up-regulation of hepatic expression of GOT1 associated with greater gluconeogenesis and insulin resistance.
Human GOT1 was expressed in E coli, purified by affinity chromatography and preliminary crystallographic studies were done.
We propose the GOT1 expression status as a simple and reliable prognostic biomarker in pancreatic ductal adenocarcinoma
Significantly higher GOT levels were found in the 1-20 year age group of type 1
The aim of this study was to establish the reference intervals (RIs) of total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate transaminase (AST), and creatinine (CREA) for apparently healthy elderly (Han ethnicity) in Shuyang, China.
Alcohol consumption, smoking status, and metabolic syndrome impact on serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT), was determined.
GOT1 is a suitable candidate gene for the serum aspartate aminotransferase activity QTL on SSC14.
Data show that the purifies prephenate aminotransferase activity is housed by the prokaryotic-type plastidic aspartate aminotransferase (At2g22250).
aspartate aminotransferase and glutamine synthetase have roles in glucocorticoid activation in mouse Schwann cells
cAspAT is a new member of glyceroneogenesis, transcriptionally regulated by TZD via the control of RORalpha expression by PPARgamma in adipocytes
These findings were largely obscured in intact mitochondria due to robust H2O2 scavenging and limited ability to control substrate concentrations in the matrix. We conclude that in mitochondria with inhibited complex I, malate/glutamate-stimulated ROS generation depends strongly on oxaloacetate removal and on the ability of KGDH to oxidize KG generated by AST.
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.
aspartate aminotransferase 1
, aspartate aminotransferase, cytoplasmic
, aspartate transaminase 1
, cysteine aminotransferase, cytoplasmic
, cysteine transaminase, cytoplasmic
, glutamate oxaloacetate transaminase 1
, growth-inhibiting protein 18
, transaminase A
, glutamate oxaloacetate transaminase 1, soluble
, Aspartate aminotransferase
, glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
, aspartate aminotransferase
, Aspartate aminotransferase, cytoplasmic
, cytosolic aspartate aminotransferase