anti-Claudin 4 (CLDN4) Antikörper

Human Claudin 4 (CLDN4) Interaktionspartner

1. HIF-1alpha (zeige HIF1A Antikörper) expression was upregulated in the vasculogenic mimicry-positive CRC (zeige CALR Antikörper) cell line HCT-116 and thereby affected the expression of the EMT (zeige ITK Antikörper)-related markers Claudin-4, E-cadherin (zeige CDH1 Antikörper) (E-cd) and Vimentin(VIM (zeige VIM Antikörper)).

2. expression of claudin-4 is highly specific for true epithelial differentiation and may be useful to distinguish SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) complex-deficient undifferentiated carcinomas from sarcomas with epithelioid morphology. The lack of claudin-4 expression in ovarian small cell carcinomas of hypercalcemic type suggests that these tumors may be better regarded as sarcomas rather than carcinomas.

3. Data indiate a regulatory network in gastric cancer whereby claudin-4 expression is reduced by specific miRNAs, which are in turn bound by specific lncRNAs acting as competing endogenous RNAs (ceRNAs), resulting in increased claudin-4 expression.

4. This is the first study to show how TGF-beta (zeige TGFB1 Antikörper) regulates the expression of Claudin-4 through c-Jun (zeige JUN Antikörper) signaling and how this pathway contributes to the migratory and tumorigenic phenotype of lung tumor cells.

5. Claudin-4 functionally contributes to both ovarian tumor cell apoptosis resistance and migration and targeting extracellular loop interactions of claudin-4 may have therapeutic implications for reducing ovarian tumor burden.

6. Fluorescence-based flow cytometry and xenon magnetic resonance imaging (MRI (zeige C7ORF49 Antikörper)) indicate binding of the biosensor specifically to claudin 4 (Cldn4)-expressing cells.

7. Studies indicate that Grainyhead-like transcription factor 2 (zeige HNF1B Antikörper) (GRHL2 (zeige GRHL2 Antikörper)) controls the expression of E-cadherin (CDH1 (zeige CDH1 Antikörper)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4) in tight junctions.

8. Studies indicate claudin 1 (CLDN-1 (zeige CLDN1 Antikörper)) as a target for improving epidermal drug absorption and preventing HCV infection and of claudin 4 (CLDN-4) as a target for anticancer therapeutics.

9. Mislocalization claudin-3 (zeige CLDN3 Antikörper) to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.

10. Reg (zeige EXTL3 Antikörper) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.

Mouse (Murine) Claudin 4 (CLDN4) Interaktionspartner

1. Reg (zeige KCNH2 Antikörper) I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4.

2. a Grhl2 (zeige GRHL2 Antikörper)/Ovol2 (zeige OVOL2 Antikörper) network controls Cldn4 and Rab25 (zeige RAB25 Antikörper) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia

3. Data show that claudin-4 and claudin-7 (zeige CLDN7 Antikörper) were observed in hepatocytes of severely damaged mouse and human livers.

4. The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1 (zeige PRSS8 Antikörper)).

5. Claudin 4 has little effect on normal lung physiology but may function to protect against acute lung injury in mice.

6. The results suggest that progressive hydronephrosis in Cldn4(-/-) mice arises from urinary tract obstruction due to urothelial hyperplasia, and that Cld4 plays an important role in maintaining the homeostatic integrity of normal urothelium.

7. the results indicate that Grhl2 (zeige GRHL2 Antikörper) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (zeige CLDN3 Antikörper) and Cldn4, as well as of Rab25 (zeige RAB25 Antikörper), which increases the Cldn4 protein and its localization at TJs

8. Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3 (zeige CLDN3 Antikörper)/-4 protein suggests structural modifications of the toxin to target specific claudins

9. Claudin-3 (zeige CLDN3 Antikörper) in the apical-most regions maintains the impermeable tight junctions during lactation, and claudin-4 contributes

10. Claudin-4 overexpression is associated with epigenetic derepression in gastric carcinoma.

Pig (Porcine) Claudin 4 (CLDN4) Interaktionspartner

1. Tumor necrosis factor-alpha (zeige TNF Antikörper) increases claudin-1 (zeige CLDN1 Antikörper), 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.

2. Claudin-4 expression shows age-dependent change in cellular localization on pig jejunal villous epithelial cells

3. These findings indicate that claudin-4 and -7 may play a role in the gingiva junctional epithelium even in the absence of tight junctions.