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Human Polyclonal TTC21B Primary Antibody für IHC, IHC (p) - ABIN4363272
Xu, Cao, Huang, Feng, Zhang, Zhu, Yan: Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function. in PLoS ONE 2015
TTC21B mutation is associated with glomerular and cystic kidney diseases.
Exome sequencing and further CRB2 (zeige CRB2 Antikörper) analysis revealed that both siblings are compound heterozygotes for CRB2 (zeige CRB2 Antikörper) mutations p.N800K and p.Gly1036Alafs*43, and heterozygous for a deleterious splice variant in the ciliopathy gene TTCB21
We demonstrated that the TTC21B gene product IFT139, an intraflagellar transport-A component, mainly localizes at the base of the primary cilium in developing podocytes from human fetal tissue and in undifferentiated cultured podocytes.
TTC21B contributes pathogenic alleles to approximately 5% of ciliopathy cases. Our data illustrate how genetic lesions can be both causally associated with diverse ciliopathies and interact in trans with other disease-causing genes
Thm1-mutant ciliary defect diminishes sensitivity to feeding signals, which alters appetite regulation and leads to hyperphagia, obesity and metabolic disease.
genetically ablated Kif3a (zeige KIF3A Antikörper), Ift88 (zeige IFT88 Antikörper), and Ttc21b in a series of specific spatiotemporal domains. The resulting phenotypes allow us to draw several conclusions. First, we conclude that the Ttc21b cortical phenotype is not due to the activity of Ttc21b within the brain itself
loss of Thm1 causes cystic kidney disease, with persistent proliferation of renal cells, elevated cAMP levels, and enhanced expression of Hedgehog (zeige SHH Antikörper) signaling genes
Data characterize the forebrain phenotype caused by loss of Ttc21b, a gene we identified in an ENU mutagenesis screen as a novel ciliary gene required for retrograde intraflagellar transport.
This gene encodes a member of TTC21 family, containing several tetratricopeptide repeat (TPR) domains. This protein is localized to the cilium axoneme, and may play a role in retrograde intraflagellar transport in cilia. Mutations in this gene are associated with various ciliopathies, nephronophthisis 12, and asphyxiating thoracic dystrophy 4.
TPR repeat protein 21B
, tetratricopeptide repeat protein 21B
, putative protein product of Nbla10696
, line 158
, tetratricopeptide repeat-containing hedgehog modulator 1