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The iRhom2 N-terminus stabilizes mature ADAM17 (zeige ADAM17 Proteine) at the cell surface where it cleaves TNF (zeige TNF Proteine) and EGFR (zeige EGFR Proteine) in inflammatory and innate immune responses. (Review)
results explain how loss of the amino terminus in iRhom1 (zeige RHBDF1 Proteine) and iRhom2 impairs TNF (zeige TNF Proteine) signaling, despite enhancing ADAM17 (zeige ADAM17 Proteine) activity
Tylosis with oesophageal cancer-associated mutations in iRHOM2 cause an increase in the maturation and activity of ADAM17 (zeige ADAM17 Proteine) in epidermal keratinocytes.
Our analyses suggest that these DNA methylation (zeige HELLS Proteine) changes may have a role in the onset of Alzheimer disease given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known susceptibility gene network.
RHBDF2 and CYGB (zeige CYGB Proteine) may play distinctive roles in ovarian cancer and could be added to the growing roster of chromosome 17 genes implicated in this disease.
The distribution of RHBDF2 in tylotic skin is altered in comparison with that in normal skin.
long-term PM2.5 exposure caused hepatic steatosis and dyslipidemia through triggering inflammation, which was, at least partly, dependent on iRhom2/TNF-alpha (zeige TNF Proteine) pathway in liver-resident macrophages
baseline expression of genes acting within the NRF2 (zeige NFE2L2 Proteine) anti-oxidative pathway, followed by gene alterations associated with the integrin receptor aggregation pathway and the FcgammaR-mediated phagocytosis pathway, contribute to accelerated wound healing
the critical role of the transmembrane domains of ADAM17 (zeige ADAM17 Proteine) and Rhbdf2 in the regulation of the ADAM17 (zeige ADAM17 Proteine) and EGFR (zeige EGFR Proteine), and ADAM17 (zeige ADAM17 Proteine) and TNFalpha (zeige TNF Proteine) signaling pathways, was examined.
this study shows that the iRhom2/ADAM17 (zeige ADAM17 Proteine) pathway plays an important role in regulating CSF1R (zeige CSF1R Proteine) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
this study shows that iRhom2-deficient mice were more susceptible to lethal herpes simplex virus type 1 infection, and that iRhom2 is essential for STING activity, as it regulates TRAPbeta (zeige SSR2 Proteine)-mediated translocation and EIF3S5 (zeige EIF3F Proteine)-mediated deubiquitination of STING
This study identifies iRhom2 as a novel regulator for determination of keratinocyte lineages.
IRhom2 may be a promising therapeutic target for LPS (zeige TLR4 Proteine)-induced cardiac injury.
iRhom2 is required for the maturation of TACE (zeige ADAM17 Proteine) and hair follicle differentiation.
a principal function of iRhoms1/2 during mouse development is to regulate ADAM17 (zeige ADAM17 Proteine)-dependent EGFR (zeige EGFR Proteine) signaling
Rhbdf2 mutations increase its protein stability and drive EGFR (zeige EGFR Proteine) hyperactivation through enhanced secretion of amphiregulin (zeige AREG Proteine).
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).
, inactive rhomboid protein 2
, rhomboid family member 2
, rhomboid veinlet-like protein 5
, rhomboid veinlet-like protein 6
, rhomboid, veinlet-like 6
, rhomboid-like protein 6
, rhomboid-related protein
, Rhomboid family member 2
, rhomboid veinlet-like 6